Cutaneous Adverse Reaction to Bio-Alcamid® Implant

Adverse reactions to injectable soft tissue fillers

“…[270][271][272][273][274][275][276][277][278] Complications secondary to the injections of Bio-Alcamid include edema (Fig 30), bruising, and nodules and, in particular, infections. [279][280][281][282][283][284][285][286] To our knowledge, no granulomas secondary to Bio-Alcamid have been described. There are few histopathologic studies describing the findings in the local reactions to Bio-Alcamid, and the microscopic study of the material obtained from an indurated nodule has shown basophilic amorphous material corresponding to the implanted material, surrounded by epithelioid histiocytes, foreign body multinucleated giant cells, neutrophils and red cells 281 (Fig 31).…”

Delayed Inflammatory Reaction to Bio-Alcamid Polyacrylamide Gel Used for Soft-Tissue Augmentation

“…Complications related to Bio-Alcamid therapy can be early and late occurring and include infection, product migration, and sterile inflammatory abscesses. 5,[9][10][11][12][13][14] Late-occurring reactions can occur months to years after injection. In 1 report 13 of 25 patients with late-occurring adverse effects caused by polyalkylimide fillers, the mean latency period between injection and symptoms was 13.4 months.…”

“…After these procedures, there may be pain and edema, as occurred in both of our patients. 5,[9][10][11][12][13][14] Serologic findings most commonly show elevated acute phase reactants, but increased angiotensin-converting enzyme (ACE) (with normal calcium levels), lactate dehydrogenase (LDH), positive antinuclear antibody, and abnormal electrophoresis abnormalities may be found. 13 Our patients declined biopsy; however, based on clinical presentation and course, these cases most likely represent late-occurring inflammatory reactions.…”

Hyaluronic acid in calves defects correction

“…Permanent liquids and gels composed of silicone, paraffin, polyalkylimide, and polyacrylamide hydrogel have been used as fillers. [1,2] However, the incidence of chronic inflammatory reaction, palpable nodule formation, granuloma formation, and migration decreased the use of these materials. [1,[3][4][5] This led to the advent of new materials that are biocompatible and nonpermanent.…”

“…[1,2] However, the incidence of chronic inflammatory reaction, palpable nodule formation, granuloma formation, and migration decreased the use of these materials. [1,[3][4][5] This led to the advent of new materials that are biocompatible and nonpermanent. In 2009, a new formulation of stabilized hyaluronic acid (HA)-based gel (NASHA-based gel; Q-Med AB, Uppsala, Sweden), was generated for restoring volume and contouring body surfaces.…”