Cutaneous Allergy and Vascular Reactions in Experimental Streptococcal Infections

Hypersensitivity Reactions in Guinea Pigs to Group A Hemolytic Streptococci

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It is generally believed that hypersensitivity to streptococci is an important factor in the pathomechanism of rheumatic fever and some other diseases [5], This belief stimulated the study of group A strepto cocci, responsible for most infections in man, and the sensitivity to these bacteria has been among the most widely investigated reactions to bacterial products [4,5,6,19]. However, in most studies only crude antigenic preparations were used and the nature of the observed reactions was not precisely determined: reactions requiring several hours to become manifest were considered as delayed, without recourse to more stringent criteria.

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