Cutaneous and Mucosal Manifestations Associated with Celiac Disease

Abstract

Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. These associated conditions may be the clue to reaching the diagnosis of CD. Over the last few years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in the absence of gastrointestinal symptoms, should give rise to an appropriate screening method for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated with CD and the possible mechanisms involved.

Opportunities and challenges in the management of celiac disease in Asia

“…While traditionally believed that the hypersensitivity to gluten peptides is limited to the small intestine in patients with CeD, it is now known that CeD affects many other organs, including skin, liver, kidney, bone, and brain, and hence, CeD is now considered to be a systemic disorder altogether. [23][24][25][26] While symptoms of CeD were typically defined as those related to malabsorption, such as chronic diarrhea, steatorrhea, weight loss, failure-to-thrive in children, short stature, irritability, excessive flatulence, and recurrent aphthous ulcers (classical CeD), [27][28][29] it is increasingly being recognized that the patients can have extraintestinal manifestations in the absence of or minimal gastrointestinal symptoms such as short stature, ataxia, hypertransaminasemia, cirrhosis of liver, and osteomalacia (atypical CeD). 30 Education and increased awareness of medical communities across specialties, as well as during initial years of training, is thus needed to allow for a timely diagnosis of CeD and institution of early intervention, which will prevent organ damage.…”

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

“…Interestingly, other autoantibodies may also be involved, especially in extraintestinal manifestations, such as anti-ganglioside, anti-synapsin I and anti-actin antibodies [ 18 ]. Patients with CD present either typical or atypical symptoms [ 19 ] and CD is believed to perpetuate other maladies and often presents simultaneously with other autoimmune diseases [ 20 , 21 , 22 , 23 ]. Despite the great progress in CD research, new key emerging findings suggest previously unknown features of CD pathogenesis, for example at the transcriptome level of immune cells [ 24 ].…”

Enfermedad celiaca silente en paciente obeso con alopecia areata

“…Esto demuestra la infrecuencia de la asociación entre estas dos patologías, uno de los motivos de impulsó este reporte. Existen pocos estudios prospectivos que demuestren la efectividad de la dieta sin gluten en la recuperación de la alopecia (5) . Aun así, esta dieta es indiscutible en la celiaquía considerando las complicaciones crónicas a la que se expone el sujeto sin tratamiento (6) .…”