Cutaneous and Renal Glomerular Vasculopathy

Jepson, Rosanne; Cardwell, Jacqueline M.; Cortellini, Stefano; Holm, Laura; Stevens, Kim; Walker, David

doi:10.1016/j.cvsm.2019.02.010

Cited by 4 publications

(22 citation statements)

References 53 publications

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“…Clinicopathological findings reported in this study are consistent with previous reports, 1,4,5,8 with anaemia, thrombocytopenia, azotaemia, increased serum liver enzyme activity and potentially proteinuria appearing frequent. Indeed, thrombocytopenia appears to be more prevalent than previously reported (83.9% versus 57.7% at presentation) 1 .…”

Section: Discussionsupporting

confidence: 93%

“…Previously, CRGV was solely associated with greyhounds in the USA 1,4-8 . In the UK only two cases have been reported in greyhounds, and this breed has been reported to not have an increased odds ratio of diagnosis 7 .…”

Section: Discussionmentioning

confidence: 96%

“…The clinical presentation reflects haemolysis and ischaemic organ dysfunction and can lead to renal and many extra‐renal manifestations 10 . Although skin involvement has been reported in complement‐mediated TMA in humans, 10,11 CRGV is the only disease in the dog reported to cause TMA in both the skin and the kidney 1,2,5 . The principal differentials for canine TMA remain CRGV (1,5) and HUS 1,5,12,13 .…”

Section: Discussionmentioning

confidence: 99%

“…Dogs present with skin lesions, predominantly affecting the distal extremities and many progress to develop AKI due to thrombotic microangiopathy (TMA) 1,4 . Multiple investigations have been performed to assess for an environmental or infectious aetiology, but currently the cause of CRGV remains unknown 1,5 . Due to the lack of identification of a definitive aetiology, attention has focused on the natural history of the disease 1,5-7 .…”

Section: Introductionmentioning

confidence: 99%

“…Multiple investigations have been performed to assess for an environmental or infectious aetiology, but currently the cause of CRGV remains unknown 1,5 . Due to the lack of identification of a definitive aetiology, attention has focused on the natural history of the disease 1,5-7 . Significant associations with habitat, breed and seasonality have previously been reported 1,6,7 .…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological features of cutaneous and renal glomerular vasculopathy in 178 dogs

Walker¹,

Holm²,

Sarmiento³

et al. 2021

Veterinary Record

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Background: One hundred seventy‐eight dogs with cutaneous and renal glomerular vasculopathy (CRGV) were evaluated to further the understanding of the natural course of CRGV. CRGV, a form of thrombotic microangiopathy, can cause skin lesions and potentially acute kidney injury (AKI) with a high mortality rate. Methods: Cases were submitted from multiple practices from 2012 until June 2019. Clinical histories and laboratory data were reviewed to describe the features of CRGV. Results: Most cases (91%) occurred between November and May. Fifteen dogs (8.4%) with CRGV were in contact with another dog that developed skin lesions +/– AKI. Limb lesions were present on 144 dogs (80.9%) at presentation. Median time from appearance of a lesion to AKI was 3 days (range –4–45 days). Neurological signs occurred in 33 dogs (18.6%) including at presentation in 2 (1.1%). Systemic signs were present in 13 dogs prior to a skin lesion (7.3%). Non‐steroidal anti‐inflammatory drugs were prescribed prior to AKI identification in 92 of 170 dogs (54.1%). Thrombocytopenia was present in 115 of 137 (83.9%) of dogs. Conclusion: The timeframe over which AKI may develop is longer than previously reported, neurological signs can be identified at presentation or during hospitalisation, and thrombocytopenia is even more common than previously reported.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinicopathological features of cutaneous and renal glomerular vasculopathy in 178 dogs

Walker¹,

Holm²,

Sarmiento³

et al. 2021

Veterinary Record

Self Cite

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Proteinuria

2023

Urinalysis in the Dog and Cat

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Approach to emergency dermatology cases in dogs and cats

Bellis¹,

Mattia²

2022

In Practice

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Background: Skin disease is a common presentation in small animal, first-opinion veterinary practice and it generally has an insidious onset, requiring long-term management by both practitioners and clients. However, there are a handful of dermatopathies that occur acutely, causing striking skin lesions and/or systemic disease. The majority of these emergency dermatopathies are not regularly seen, thus the literature is minimal and practitioners may not be familiar with their aetiology, clinical appearance, diagnosis, treatment and prognosis.

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Cutaneous and Renal Glomerular Vasculopathy

Cited by 4 publications

References 53 publications

Clinicopathological features of cutaneous and renal glomerular vasculopathy in 178 dogs

Clinicopathological features of cutaneous and renal glomerular vasculopathy in 178 dogs

Proteinuria

Approach to emergency dermatology cases in dogs and cats

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