Cutaneous Angiosarcoma

Mendenhall, William M.; Mendenhall, Charles M.; Werning, John W.; Reith, John D.; Mendenhall, Nancy P.

doi:10.1097/01.coc.0000227544.01779.52

Cited by 164 publications

(165 citation statements)

References 25 publications

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“…In terms of radiation dose, several authors generally recommend approximately 60 Gy in 30 fractions for treatment of a primary tumour [3,14]. In the current study, of the patients treated with radiotherapy only (macroscopic disease), in-field recurrence occurred in 4 of 11 patients (36.4%) treated with less than 70 Gy, while none of 14 patients treated with 70 Gy or more had in-field recurrence.…”

Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 46%

“…Cutaneous angiosarcomas can occur as lesions in any part of the body, but most frequently arise on the scalp and face of elderly people [1,2]. Several investigators have suggested that angiosarcomas of the scalp and face form a distinctive subgroup due to their extremely poor prognosis, with 5-year survival of only 10-15% [1][2][3]. This highly aggressive tumour spreads widely through the skin, recurs locally and metastasises early.…”

mentioning

confidence: 99%

“…Surgery was the mainstay of treatment, but the high frequency of local recurrence of this strategy is discouraging [1,2]. Radiotherapy was generally performed in cases of widely spread and unresectable tumours, but the outcomes were also unsatisfactory [1,3]. Therefore, several authors advocated a combination of surgery and radiotherapy for these tumours [3,6,7].…”

mentioning

confidence: 99%

“…Radiotherapy was generally performed in cases of widely spread and unresectable tumours, but the outcomes were also unsatisfactory [1,3]. Therefore, several authors advocated a combination of surgery and radiotherapy for these tumours [3,6,7]. Recently, chemotherapy and immunotherapy using recombinant interleukin-2 (rIL-2) have been studied as potential treatments [8,9].…”

mentioning

confidence: 99%

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Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Ogawa

Takahashi²,

Asato³

et al. 2012

The British Journal of Radiology

104

123

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Objective: The objective of this study was to retrospectively analyse the treatment results of clinically localised angiosarcoma of the scalp and face. Methods: The records of 48 patients who were treated between 1987 and 2009 were reviewed. single modality or a combination of surgery, radiotherapy, chemotherapy and immunotherapy were administered. The median follow-up of all 48 patients was 13.7 months (range 2.5-105.9 months). Results: At the time of analysis, 45 of 48 patients (93.8%) had disease recurrences, and the lung was the most frequent site for recurrence (37 patients). In multivariate analysis, performance status (PS) and number of tumours were significant predictors of lungmetastasis-free (LMF) rate. For patients with multifocal tumours, chemotherapy use significantly decreased the LMF rate (p50.0072). The 2-year actuarial overall survival (OS), progression-free survival and local control rates in all 48 patients were 22.1%, 10.7% and 46.3%, respectively. In multivariate analysis, PS, number of tumours, surgery and radiotherapy were significant prognostic factors for OS. Patients treated with both surgery and radiotherapy (2-year OS: 45.8%) had a significantly more favourable OS (p,0.0001) than patients treated with either surgery or radiotherapy (2-year OS: 11.1%) and patients treated with neither surgery nor radiotherapy (2-year OS: 0%). Conclusions: Our results indicated that PS and number of tumours were significant predictors for developing lung metastases. Our results also indicated that PS, number of tumours, surgery use and radiotherapy use were independent prognostic factors for OS. Multimodal treatments including surgery and radiotherapy were effective in improving OS for patients with these tumours. Advances in knowledge: Multimodal treatments including surgery and radiotherapy are effective in improving overall survival for patients with angiosarcoma of the scalp and face.

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Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 46%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Ogawa

Takahashi²,

Asato³

et al. 2012

The British Journal of Radiology

104

123

View full text Add to dashboard Cite

show abstract

“…Surgical intervention is limited to local control and is not recommended for widely disseminated disease. Current guidelines call for total surgical resection of the tumor with wide negative margins to reduce reoccurrence (Lahat et al 2009;Mendenhall et al 2006). However, the multicentric nature of cutaneous AS and its proximity to vital organs in visceral disease makes achieving complete tumor resection difficult.…”

Section: Prognosis and Treatmentmentioning

confidence: 99%