Cutaneous Angiosarcoma of the Breast After Segmental Mastectomy and Radiation Therapy

Sessions, Scott C.

doi:10.1001/archsurg.1992.01420110114023

Cited by 30 publications

(7 citation statements)

References 10 publications

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“…Cutaneous angiosarcoma is an aggressive malignancy which consists of three types; 1) angiosarcoma without lymphedema of the face and scalp in the elderly (Wilson‐Jones angiosarcoma), 2) angiosarcoma secondary to chronic persistant lymphedema, and 3) angiosarcoma on areas treated previously with radiotherapy (1–3).…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Angiosarcoma of the Face

Kikuchi

Kurokawa

Setoyama

2004

The Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

Two Cases of Angiosarcoma of the Face

Kikuchi

Kurokawa

Setoyama

2004

The Journal of Dermatology

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“…On the other hand, the carcinogenic effect of exposure to ionizing radiation may induce the development of malignant tumours, including sarcomas 12 . A number of radiation‐induced angiosarcomas have been described at the site of mastectomy in patients with carcinoma of the breast receiving radiotherapy 13 –18…”

Section: Discussionmentioning

confidence: 99%

Benign lymphangiomatous papules of the skin following radiotherapy: a report of five new cases and review of the literature

et al. 1999

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Our cases provide additional evidence supporting the benign nature of this atypical vascular proliferation, not recurring, never developing metastases and being cured readily by local excision. Clinical, histopathological and ultrastructural findings suggest a lymphatic origin. Whether these lesions represent a neoplastic or a reactive condition secondary to radiotherapy is unclear. The name 'benign lymphangiomatous papules of the skin following radiotherapy' is proposed.

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“…The bulk of studies identified in this systematic review were small case series and case reports [ 7 , 8 , 13 – 44 , 46 – 63 , 65 – 67 , 70 , 72 – 80 ]. As expected, the heterogeneity among these studies with low numbers of RASB patients was considerable.…”

Section: Literature Reviewmentioning

confidence: 99%

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

et al. 2018

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BackgroundRadiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy.Case presentationWe present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor. In August 2016, a bilateral salpingo-oophorectomy was performed to remove a tumor of the left ovary, which was diagnosed as breast cancer recurrence. At the same time, a small, purple skin lesion of 1.2 cm in diameter was noted in the inner upper quadrant of the right breast. RASB was diagnosed by punch biopsy and the tumor was excised with clear margins. Imaging studies showed no evidence of further metastases. A systemic chemotherapy with 6 cycles of liposomal doxorubicin was initiated. Five months later, a local recurrence of RASB was diagnosed and mastectomy was performed. Six months later, the patient is alive with no evidence of disease.Three hundred seven cases of RASB were identified. The pooled incidence rate of RASB was 1/3754 women. The most common treatment of RASB was mastectomy in 83% of cases. Adjuvant radiotherapy or chemotherapy were rarely used with 6 and 4%, respectively, whereas in case of recurrence, chemotherapy was the mainstay of treatment, used in 58% of cases. Radiotherapy and repeated surgery were also common with 30 and 33% of cases, respectively. Overall, the prognosis of women with RASB was poor and the recurrence-free survival was short with a mean of 15.9 months. Mean overall survival was 27.4 months.ConclusionRASB is a rare late complication of breast irradiation. The prognosis of women with RASB is poor. Surgery is the mainstay of treatment for localized disease while systemic chemotherapy and re-irradiation are appropriate for women with disseminated or recurrent RASB.

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Cutaneous Angiosarcoma of the Breast After Segmental Mastectomy and Radiation Therapy

Cited by 30 publications

References 10 publications

Two Cases of Angiosarcoma of the Face

Two Cases of Angiosarcoma of the Face

Benign lymphangiomatous papules of the skin following radiotherapy: a report of five new cases and review of the literature

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

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