Cutaneous Aspects of the XXYY Genotype

Peterson, Willard C.

doi:10.1001/archderm.1966.01600300019004

Cited by 16 publications

(4 citation statements)

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“…Several reports have suggested that hypostatic ulceration and varicose veins are particularly frequent in the 48,XXYY variant of Klinefelter's syndrome (Cam et al 1961, Ellis et al 1961, Barr et al 1964, Peterson et al 1966, Beckman et al 1974, although other workers have not found this to be the case (Borgaonkar et al 1970(Borgaonkar et al , S@rensen et al 1978. Of 20 patients known to us with the 48,XXYY karyotype or a 48, XXYY cell line, three (15 YO) are known to have hypostatic ulceration and seven (35 70) to have varicose veins, proportions not significantly different from those for chromatin-positive men as a whole (P = 0.1).…”

Section: Discussionmentioning

confidence: 99%

Venous thromboembolic disease in Klinefelter's syndrome

Campbell

Price

1981

Clinical Genetics

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In a series of 412 patients with Klinefelter's syndrome observed over periods ranging from 1 to 20 years, the frequency of hypostatic ulceration, deep vein thrombosis and pulmonary embolism was found to be raised. The prevalence of past or present hypostatic ulceration was 6 Yr, which is 20-50 times higher than in the general population. The incidence of deep vein thrombosis in subjects aged between 30 and 70 years was 22.8 cases per 10,000 patient-years at risk. In community studies the incidence of this condition is around 4 new cases per 10,000 men per year. The frequency of pulmonary embolism was 16 cases per 10,000 patient-years at risk, compared with an expected figure of 0.9 to 3 cases per 10,000 men per year.

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Section: Discussionmentioning

confidence: 99%

Venous thromboembolic disease in Klinefelter's syndrome

Campbell

Price

1981

Clinical Genetics

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“…Klinefelter's chromosome anomaly-usually XXY-occurs with an incidence of one in 400 males (Rook et al, 1972). The clinical picture includes eunuchoid body proportions, testicular atrophy, sterility, gynaecomastia, reduced growth of beard, decreased body hair and lack of acne vulgaris (Peterson et al, 1966;Eroland, 1969). These men are also taller than the average.…”

Section: Discussionmentioning

confidence: 99%

“…Thomsen (1966) reported four cases of Klinefelter's syndrome of which two had leg ulcers and one intermittent oedema of the lower legs complicated by purpura of unknown origin. Peterson et al (1966) found five patients with a variant of Khnefcltcr's syndrome (XXYY) and peripheral vascular disease resulting in early onset of stasis dermatitis and in one, stasis ulceration. A possible influence of abnormal metabolism on blood vasculature was discussed.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the association found in the hitherto reported cases and in our own patients might be a coincidence. However, hormonal factors that in other disorders are known to affect vasculature (Bean, 1958) could perhaps play a part in these syndromes (Peterson et al, 1966) in addition to the effect of the increased height and weight of these patients, which causes a greater strain on the vasculature of the lower legs.…”

Section: Discussionmentioning

confidence: 99%

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