Cutaneous blood flow in dermatomyositis and its association with disease severity

Dawn, Aerlyn G.; Thevarajah, Suganthi; Cayce, Kimberly A.; Carroll, Christie L.; Duque, Maria L.; Chan, Yiong Huak; Jorizzo, Joseph L.; Yosipovitch, Gil

doi:10.1111/j.1600-0846.2007.00226.x

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…5 Visualization of superficial microvasculature and sensitive assessment of blood volume dynamics is hypothesized to be of added value in several pathologies with cutaneous involvement, such as systemic sclerosis and dermatomyositis. [6][7][8] Imaging of superficial tissue is an appealing application for PA because only a limited imaging depth is required. 2 Several groups have shown how PA imaging, in different implementations and combined with other modalities, can be used to assess (sub) dermal vascular geometry and functioning in vivo.…”

Section: Introductionmentioning

confidence: 99%

Visualization of vasculature using a hand-held photoacoustic probe: phantom and in vivo validation

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Visualization of vasculature using a hand-held photoacoustic probe: phantom and in vivo validation

et al. 2017

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Human Skin Microcirculation

Cracowski

Roustit

2020

Comprehensive Physiology

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The anatomy and physiology of the microcirculation in human skin are complex. Normal cutaneous microcirculation is organized in two parallel plexuses with capillary loops extending perpendicularly from the superficial plexus. The physiological regulation of cutaneous microcirculation includes specific sympathetic activation, which causes vasoconstriction through the release of norepinephrine, neuropeptide Y, and ATP. A sympathetic cholinergic system is mainly involved in vasodilation through the co-transmission of acetylcholine, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide. Sensory nerves play a major role through the release of calcitonin gene-related peptide and substance P. Endothelium-dependent vasomotion implicates nitric oxide, prostacyclin, endothelium-dependent hyperpolarizing factors, and endothelin. Myogenic response also plays a role and explains why autoregulation is weak but exists in glabrous human skin. Variations in skin blood flow result from highly complex interactions between these mechanisms. In this article, we will detail the anatomy, physiology, and current methods of exploring the human microcirculation. We will further discuss the part played by cutaneous microvascular impairment in the pathophysiology of cardiovascular and metabolic diseases, or diseases more specifically affecting the skin.

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Dendritic Cells in Atherosclerosis

Butcher

Galkina

2014

Encyclopedia of Medical Immunology

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Cutaneous blood flow in dermatomyositis and its association with disease severity

Abstract: DM is associated with significantly increased cutaneous blood flow, even at sites where no erythema is evident. This suggests significant involvement of the skin vasculature in this disease process.

Cited by 6 publications

References 37 publications

Visualization of vasculature using a hand-held photoacoustic probe: phantom and in vivo validation

Visualization of vasculature using a hand-held photoacoustic probe: phantom and in vivo validation

Human Skin Microcirculation

Dendritic Cells in Atherosclerosis

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