Cutaneous Calcification in Patients With End-Stage Renal Disease

Rivet, Jacqueline; Lebbe, Célèste; Ureña, Pablo; Cordoliani, F.; Martinez, F.; Baglin, A.C.; Aubert, P; Aractingi, S.; Ronco, Pierre; Fournier, Philippe; Janin, Anne

doi:10.1001/archderm.142.7.900

Cited by 28 publications

(11 citation statements)

References 22 publications

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“…A growing body of research supports a link between bone and vascular calcification. In fact, persistent uremia and elevated phosphate levels cause transdifferentiation of pluripotent vascular smooth muscle cells into osteoblastic‐like cells (22,28–31). Elevated phosphate levels and osteoblastic transformation result in elevated osteoponin levels (22,32).…”

mentioning

confidence: 99%

Dermatologic Conditions Seen in End‐Stage Renal Disease

Cordova

Oberg

Malik

et al. 2009

Seminars in Dialysis

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The skin changes reported in patients with end-stage renal disease (ESRD) are diverse and manifold. In this article we focus on a collection of specific cutaneous entities seen most frequently in the setting of ESRD, each presenting with distinctive and unique morphology. These include perforating disorders, porphyria cutanea tarda, pseudoporphyria, calcinosis cutis, calciphylaxis, and nephrogenic systemic fibrosis. The clinical features, histopathology, pathophysiology, differential diagnosis, and management of each entity are reviewed.

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mentioning

confidence: 99%

Dermatologic Conditions Seen in End‐Stage Renal Disease

Cordova

Oberg

Malik

et al. 2009

Seminars in Dialysis

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“…Immunohistochemical analyses confirm the upregulation of key bone matrix proteins that may contribute to both intravascular and extravascular calcification. 10 When dystrophic calcification occurs in the skin and subcutaneous tissues, it is referred to as dystrophic-type calcinosis cutis. While it is a rare complication of renal insufficiency, dystrophic-type calcinosis cutis is most commonly associated with inflammatory diseases, including systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Severe Dystrophic Calcification of a Spinal Cord Stimulator Pulse Generator Pocket: A Case Report

Kim

Sobey

2023

A&A Practice

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A spinal cord stimulator is an important long-term treatment modality for refractory chronic pain of multiple etiologies. Hardware-related complications remain known adverse events associated with this intervention. Understanding the risk factors for development of such complications is important for optimizing the efficacy and longevity of spinal cord stimulators. This case report highlights an uncommon case of implantable pulse generator site calcification that was discovered incidentally on spinal cord stimulator explant.

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“…Similarly, intracranial artery calcification is associated with chronic kidney disease in humans, and this correlates with an increase in stroke occurrence (Bugnicourt et al 2009). CNS microvessels, including arterioles and less studied capillaries, may also experience this process, since patients with end-stage renal disease develop cutaneous calcification of subcutaneous arterioles and capillaries (Rivet et al 2006), resulting in a condition called calcific uraemic arteriolopathy (Sowers and Hayden 2010).…”

Section: Vessel Calcificationmentioning

confidence: 99%

“…CNS microvessels, including arterioles and less studied capillaries, may also experience this process, since patients with end‐stage renal disease develop cutaneous calcification of subcutaneous arterioles and capillaries (Rivet et al . ), resulting in a condition called calcific uraemic arteriolopathy (Sowers and Hayden ).…”

Section: Role Of Brain Pericytes In Neurological Disorders Associated...mentioning

confidence: 99%

The role of pericytes in brain disorders: from the periphery to the brain

Hirunpattarasilp

Attwell

Freitas

2019

Journal of Neurochemistry

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It is becoming increasingly apparent that disorders of the brain microvasculature contribute to many neurological disorders. In recent years it has become clear that a major player in these events is the capillary pericyte which, in the brain, is now known to control the blood–brain barrier, regulate blood flow, influence immune cell entry and be crucial for angiogenesis. In this review we consider the under‐explored possibility that peripheral diseases which affect the microvasculature, such as hypertension, kidney disease and diabetes, produce central nervous system (CNS) dysfunction by mechanisms affecting capillary pericytes within the CNS. We highlight how cellular messengers produced peripherally can act via signalling pathways within CNS pericytes to reshape blood vessels, restrict blood flow or compromise blood–brain barrier function, thus causing neuronal dysfunction. Increased understanding of how renin–angiotensin, Rho‐kinase and PDGFRβ signalling affect CNS pericytes may suggest novel therapeutic approaches to reducing the CNS effects of peripheral disorders.

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Cutaneous Calcification in Patients With End-Stage Renal Disease

Cited by 28 publications

References 22 publications

Dermatologic Conditions Seen in End‐Stage Renal Disease

Dermatologic Conditions Seen in End‐Stage Renal Disease

Severe Dystrophic Calcification of a Spinal Cord Stimulator Pulse Generator Pocket: A Case Report

The role of pericytes in brain disorders: from the periphery to the brain

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