Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin

Wiebel, Friedrich J.; Gelboin, Harry V.

doi:10.1002/cphy.cp090121

Cited by 3 publications

(3 citation statements)

References 127 publications

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“…Other compounds such as -naphtho#avone (BNF) a (PAH-like compound) are strong ethoxyresoru"n O-deethylase (EROD) inducers Santos, 1998, Schlezinger andStegeman, 2000). This synthetic #avonoid compound produces e!ects on the microsomal cytochrome P-450 (P450)-dependent monooxygenase system, which is involved in the metabolic activation and detoxi"cation of a wide range of procarcinogenic contaminants (Wiebel, 1980). A number of "sh studies on the genotoxic e!ects of BaP and/or BNF have been performed using cytogenetic tests, such as the presence of micronuclei (Grinfeld et al, 1986), erythrocytic nuclear abnormalities (ENA) Santos, 1997, 1998), chromosome aberrations (Hoofman, 1981), and tumor detection (Hendricks et al, 1985, Hawkins et al, 1988.…”

Section: Introductionmentioning

confidence: 99%

Benzo[a]pyrene and β-Naphthoflavone Mutagenic Activation by European Eel (Anguilla anguilla L.) S9 Liver Fraction

Maria

Correia

Santos

2002

Ecotoxicology and Environmental Safety

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Is Anguilla anguilla L. (eel) liver ethoxyresorufin O-deethylase (EROD) induction absolutely necessary in order to convert promutagens as benzo[a]pyrene (BaP) into a mutagenic compound? Eels were exposed for 8 h to clean (control) and 0.3 microM beta-naphthoflavone (BNF)-contaminated water. The 8-h exposure to 0.3 microM BNF brought about a very high EROD induction (10 pmol/min/mg protein) compared to control animals (1 pmol/min/mg protein). The Ames test (Maron and Ames, 1983) was carried out with Salmonella typhimurium TA 98 strain (TA98 His-) and eel isolated S9 liver fraction was used as a metabolic BaP activator. The BaP and BNF dose range concentrations tested were 0 (blank), 0.015, 0.08, 0.15, 0.38, 0.75, 1.5, 3.8, and 7.5 microM/plate and 0 (blank), 0.412, 1.235, 3.704, 11.1, 33.0, and 100 nM BNF, respectively. A dose-response relationship between BaP concentration and mutagenic activity was observed in the presence of S9 fractions in control and 0.3 microM BNF-exposed eels. Significant positive results, as TA98 His+ revertants, were observed at 0.38, 0.75, 1.5, 3.8, and 7.5 microM BaP/plate induced by BNF S9 fractions. Significant BaP mutagenic activation by liver control S9 was detected only at 1.5, 3.8, and 7.5 microM/plate. The BaP 1.5, 3.8, and 7.5 microM/plate mutagenic activation by BNF S9 and control S9 were not significantly different. Relative to BNF activation, it was only possible to detect His+ reversion at 11.1 nM BNF concentration with 0.3 microM BNF-induced S9. The above results demonstrate that the eel S9 liver fraction has the capacity to biotransform high BaP concentrations and convert it into a mutagenic compound with or without previous liver BNF biotransformation induction. The same does not apply to low BaP concentrations, where liver S9 induction by BNF is necessary to promote mutagenesis.

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Section: Introductionmentioning

confidence: 99%

Benzo[a]pyrene and β-Naphthoflavone Mutagenic Activation by European Eel (Anguilla anguilla L.) S9 Liver Fraction

Maria

Correia

Santos

2002

Ecotoxicology and Environmental Safety

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“…• змінити структуру ліпофільної молекули шляхом переведення її у водорозчинну форму для виведення з організму [2,8].…”

Section: зв'язок публікації із плановими науково-дослідними роботамиunclassified

“…• change the structure of the lipophilic molecule by converting it into a water-soluble form for excretion from the body [2,8].…”

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confidence: 99%

Control of the Pharmacogenetics of Enzymes’ Medicine Biotransformation – A Tool for Providing Personalized Medicine

Yakovleva

Жамба

Hoina-Kardasevich

et al. 2023

VPBM

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Вісник проблем біології і медицини -2023 -Вип. 2 (169) / Bulletin of problems in biology and medicine -2023 -Issue 2 (169) 121 ОГЛЯДИ ЛІТЕРАТУРИ / LITERATURE REVIEWSSenile asthenia (SA) is the leading geriatric syndrome which characterizes the most vulnerable group of older patients. At the same time, senile asthenia is closely associated with other common geriatric syndromes, such as sarcopenia, malnutrition, reduced mobility and falls, cognitive impairment and depression. Despite widespread adoption, geriatric syndromes often remain undiagnosed. As a result, it leads to the patient functional dependence and reduced quality of life, increasing the number of hospitalizations and the risk of death.Concepts such as active longevity and healthy aging are increasingly used in society to develop action strategies aimed at supporting the elderly and senile age.Preventive and screening programs directed at preventing premature aging of the population and early detection of patients with risk factors for development of senile asthenia or its manifest signs are necessary.Conclusions. Thus, the management of elderly and senile patients with polymorbidity should take into account the presence of senile asthenia, the patient's life priorities and be focused on the optimal quality of life and supporting the patient's independence from outside assistance.

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Epidermal enzyme-mediated mutagenicity of the skin carcinogen, 2-aminoanthracene

Bickers

Mukhtar

Meyer

et al. 1985

Mutation Research/Environmental Mutagenesis and Related Subject

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Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin

Cited by 3 publications

References 127 publications

Benzo[a]pyrene and β-Naphthoflavone Mutagenic Activation by European Eel (Anguilla anguilla L.) S9 Liver Fraction

Benzo[a]pyrene and β-Naphthoflavone Mutagenic Activation by European Eel (Anguilla anguilla L.) S9 Liver Fraction

Control of the Pharmacogenetics of Enzymes’ Medicine Biotransformation – A Tool for Providing Personalized Medicine

Epidermal enzyme-mediated mutagenicity of the skin carcinogen, 2-aminoanthracene

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