Cutaneous CD30+ lymphoproliferative disorders: Expression of bcl-2 and proteins of the tumor necrosis factor receptor superfamily

Paulli, Marco; Berti, Emilio; Boveri, Emanuela; Kindl, S.; Bonoldi, Emanuela; Gambini, Claudio; Rosso, Renato; Borroni, G.; Stracca-Pansa, Vincenzo; Magrini, Umberto; DeCoteau, John E; Krammer, Peter H.; Möller, Peter; Kadin, Marshall E.

doi:10.1016/s0046-8177(98)90249-0

Cited by 33 publications

(21 citation statements)

References 60 publications

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“…Kikuchi and Nishikawa 36 demonstrated that CD30-positive lymphoproliferative disorders of the skin, which characteristically have an indolent course, undergo significantly more apoptosis than other cutaneous lymphoproliferative disorders. The demonstration that many CD30-positive neoplastic cells strongly express the FAS receptor, 37,38 a molecule known to regulate a key apoptotic pathway, as well as FADD and caspase-3, provided further support for involvement of apoptosis in spontaneous regression of these cutaneous lymphomas. 26 Along these lines, we hypothesized that apoptosis may play a role in the indolent behavior of spermatocytic seminomas compared to usual seminomas.…”

Section: Discussionmentioning

confidence: 89%

Apoptosis in spermatocytic and usual seminomas: a light microscopic and immunohistochemical study

et al. 2007

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Despite its alarming appearance, spermatocytic seminoma virtually never metastasizes. We hypothesized that this paradox may at least be partially related to increased apoptosis compared to metastasizing germ cell tumors since high expression of proapoptotic factors correlates with indolent behavior in other tumor systems, notably CD30-positive cutaneous lymphoma, another neoplasm where phenotype and behavior do not match. We therefore compared apoptosis and apoptotic regulators in 17 spermatocytic seminomas (2 with sarcoma) and 18 usual seminomas by light microscopy and using immunostains for caspase-3, p53, bcl-2, bcl-xL, FADD, FAS and survivin. We found significantly greater numbers of apoptotic cells and activated caspase-3-positive cells in spermatocytic seminoma compared to usual seminoma (Po0.01). There was over a 10-fold range in apoptotic cells in usual seminoma but only a 4-fold variation in spermatocytic seminoma. Spermatocytic seminoma had decreased p53 expression compared to usual seminoma, with marked variation in bcl-2 expression and increased FADD. The two sarcomas in spermatocytic seminoma, however, showed decreased apoptosis and caspase-3 reactivity, with upregulation of p53 and bcl-2 and decreased FADD expression. We conclude that apoptosis, caspase-3 and FADD expression are increased in spermatocytic seminoma compared to usual seminoma. Apoptotic parameters are decreased in sarcomatous transformation of spermatocytic seminoma. The increased apoptosis of spermatocytic seminoma, possibly mediated by FAS independent activation of the death receptor pathway, may provide some insight into its excellent prognosis. The variation in apoptosis of usual seminomas merits investigation as a prognostic parameter.

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Section: Discussionmentioning

confidence: 89%

Apoptosis in spermatocytic and usual seminomas: a light microscopic and immunohistochemical study

et al. 2007

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“…34 Bcl-2 was not found to be expressed by CD30+ large atypical cells in LyP, thus providing a molecular distinction between LyP and a pleomorphic subset of c-ALCL. Antisense Bcl-2 has been used for treatment of follicular lymphoma 79 and therefore can be considered for therapy of selected pleomorphic CD30+ cutaneous lymphomas 34,35 protected from apoptosis by Bcl-2. Overexpression of AP1/JunB has been recognized as a characteristic of cutaneous T-cell lymphoma, including CD30+ ALCL.…”

Section: Altered Gene Expression As a Basis For Classification And Tamentioning

confidence: 83%

“…Bcl-2 is rarely expressed by large atypical cells in LyP but is often expressed in pleomorphic cells of CD30+ large-cell lymphoma and 30% of c-ALCL. [34][35][36] Fascin is expressed more frequently in ALCL and LyP associated with ALCL than in uncomplicated LyP. 37 CLA is invariably expressed by large cells in LyP but variably in c-ALCL and is decreased in extracutaneous spread of ALCL (Fig 3A-B).…”

Section: Distinction Between Lyp and Alclmentioning

confidence: 99%

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Need for an Improved Molecular/Genetic Classification for CD30+ Lymphomas Involving the Skin

2007

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“…Few studies have examined the expression of these apoptosis-related proteins in cutaneous and noncutaneous CD30-positive LPDs (21). Because of the propensity for PC CD30-positive LPDs to undergo regression, examination of factors involved in apoptosis may be relevant in the pathobiology of these processes.…”

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confidence: 99%

Immunohistochemical Analysis of CD30-Positive Lymphoproliferative Disorders for Expression of CD95 and CD95L

Sigel

Hsi

2000

Modern Pathology

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Cutaneous CD30+ lymphoproliferative disorders: Expression of bcl-2 and proteins of the tumor necrosis factor receptor superfamily

Cited by 33 publications

References 60 publications

Apoptosis in spermatocytic and usual seminomas: a light microscopic and immunohistochemical study

Apoptosis in spermatocytic and usual seminomas: a light microscopic and immunohistochemical study

Need for an Improved Molecular/Genetic Classification for CD30+ Lymphomas Involving the Skin

Immunohistochemical Analysis of CD30-Positive Lymphoproliferative Disorders for Expression of CD95 and CD95L

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