Cutaneous Collagenous Vasculopathy: Description of Two New Cases in Elderly Women and Review of the Literature

Fernández, Daniel González; Bernal, Silvia Gómez; Allende, Blanca Vivanco; Oliva, Narciso Pérez

doi:10.1159/000339770

Cited by 23 publications

(17 citation statements)

References 20 publications

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“…CCV has almost exclusively been reported in middle-aged subjects [3], even though 1 pediatric case has been reported [4]. In our patient, cutaneous telangiectasia originally developed on the lower legs and progressed subsequently to the thighs, trunk and the upper extremities in accordance with data reported in the literature [5].…”

Section: Discussionsupporting

confidence: 88%

“…Sparse lymphocytes scattered around the vessel walls may be found. Electron microscopy studies disclose dilated postcapillary venules with flat endothelial cells and a thickened laminated basement membrane consisting of an amorphous eosinophilic hyaline material [2,3]. By immunohistochemistry, vascular cells of endothelial origin are CD31 and CD34 positive.…”

Section: Discussionmentioning

confidence: 99%

“…CCV has to be differentiated from a number of other vascular disorders presenting with cutaneous telangiectasias, including benign hereditary telangiectasia, angioma serpiginosum and telangiectasia macularis eruptiva perstans [3]. Generalized essential telangiectasia (GET) [8] is another benign condition that should be differentiated from CCV.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Collagenous Vasculopathy: A Rare Form of Microangiopathy Successfully Treated with a Combination of Multiplex Laser and Optimized Pulsed Light with a Review of the Literature

et al. 2015

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Cutaneous collagenous vasculopathy (CCV) is a rare idiopathic microangiopathy of the cutaneous vasculature characterized histologically by the presence of dilated small blood vessels with flat endothelial cells and thickened walls containing hyaline material in the upper dermis. We report an elderly patient presenting with an extensive form of CCV involving the trunk, upper and lower limbs. She was treated with Multiplex PDL 595-nm/Nd:YAG 1,064-nm laser and optimized pulsed light. This approach, which has never been reported for CCV so far, resulted in a striking and almost complete clearance of the widespread lesions. We here review our knowledge about CCV and therapeutic options available with a survey of the literature.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cutaneous Collagenous Vasculopathy: A Rare Form of Microangiopathy Successfully Treated with a Combination of Multiplex Laser and Optimized Pulsed Light with a Review of the Literature

et al. 2015

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“…Family history is negative for telangiectasias or bleeding disorders and there is no consistent association with a specific medical disorder 2. Although most cases of CCV described had some associated disease and received various treatments, these associations are probably fortuitous and related to the age of the patients 2 8…”

Section: Discussionmentioning

confidence: 99%

“…CCV is characterised by progressive development of generalised cutaneous telangiectases with unique but subtle histological features, consisting of dilated blood vessels of the superficial dermal plexus with marked wall thickening due to collagen deposition 6 7. Because it is clinically indistinguishable from generalised essential telangiectasia (GET), differing in its histology, it is possible that some cases clinically suspected to be GET may actually represent CCV 8. We describe a new case of CCV to increase awareness of this still poorly known condition and emphasise the importance of clinicopathological correlation in the differential diagnosis of generalised telangiectasias.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous collagenous vasculopathy: a rare cause of generalised cutaneous telangiectasia

et al. 2015

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Cutaneous collagenous vasculopathy is a rare cutaneous microangiopathy of unknown aetiology with only 27 cases reported to date. It is characterised clinically by generalised cutaneous telangiectasias and microscopically by dilation and marked thickening of the walls of superficial dermal blood vessels. Differential diagnosis should be performed with other causes of disseminated telangiectasias, including generalised essential telangiectasia, from which it is clinically indistinguishable. We report a new case of cutaneous collagenous vasculopathy in a 61-year-old woman presenting with a 5-year history of asymptomatic telangiectasias distributed symmetrically on her upper and lower limbs and highlight the importance of clinicopathological correlation for the diagnosis of this disease.

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Telangiectasias on the Lower Extremity

2018

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A woman in her 80s presented with a 1-year history of blanchable, salmon-colored, monomorphic macules and fine telangiectasias localized to her right lower leg (Figure , A). The asymptomatic patch had slowly enlarged since initial onset, but remained confined to the single extremity. Physical examination revealed agminated and discrete erythematous macules as well as interspersed fine, reticulated telangiectases over the right pretibial leg (Figure , B). No edema or warmth of the affected area was observed, and there was no evidence of mucosal, conjunctival, or nail involvement. Findings on review of systems were negative for bleeding tendencies or hypercoagulability. A punch biopsy was performed (Figure , C and D). Diagnosis C. Cutaneous collagenous vasculopathy (CCV) Microscopic Findings and Clinical CourseHistopathologic examination demonstrated the presence of multiple dilated, thin-walled capillaries located within the papillary dermis. The vessel walls were surrounded by thick, concentric depositions of pink hyaline material (Figure , C) that was highlighted with periodic acid-Schiff (PAS) stain (Figure, D). No fibrin thrombi or vasculitis was identified. Congo red staining was negative for amyloid. These clinicopathologic findings are consistent with CCV. DiscussionCutaneous collagenous vasculopathy is a distinct form of idiopathic, primary cutaneous microangiopathy, affecting superficial dermal blood vessels. Clinically, CCV presents as asymptomatic, Clinical view A Close clinical view B Hematoxylin-eosin stain C Periodic acid-Schiff stain D Figure. A, Reticulated, blanchable, salmon-colored patch on the pretibial leg. B, Individual fine, telangiectatic erythematous macules identified on closer inspection. C, Concentric deposits of hyaline material surround dilated and markedly thickened capillaries within the papillary dermis (original magnification ×200). D, Perivascular hyaline deposits are highlighted strongly by periodic acid-Schiff stain (original magnification ×200). WHAT IS YOUR DIAGNOSIS? A. Essential telangiectasia B. Leukocytoclastic vasculitis C. Cutaneouscollagenousvasculopathy D. Pigmented purpuric dermatosis, Schamberg type Clinical Review & Education

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Cutaneous Collagenous Vasculopathy: Description of Two New Cases in Elderly Women and Review of the Literature

Cited by 23 publications

References 20 publications

Cutaneous Collagenous Vasculopathy: A Rare Form of Microangiopathy Successfully Treated with a Combination of Multiplex Laser and Optimized Pulsed Light with a Review of the Literature

Cutaneous Collagenous Vasculopathy: A Rare Form of Microangiopathy Successfully Treated with a Combination of Multiplex Laser and Optimized Pulsed Light with a Review of the Literature

Cutaneous collagenous vasculopathy: a rare cause of generalised cutaneous telangiectasia

Telangiectasias on the Lower Extremity

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