Cutaneous cysts

Calonje, Eduardo; Brenn, Thomas; Lazar, Alexander J.

doi:10.1016/b978-1-4160-5649-2.00034-2

Cited by 80 publications

(187 citation statements)

References 286 publications

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“…Finally, while BCCs show occasional mitotic figures and apoptosis, they may be absent in TEs (table 1). 3 4 7…”

Section: Cutaneous Adnexal Tumours With Follicular Lineagementioning

confidence: 99%

“…Trichilemmal keratinisation is usually noted and a classical pilar (trichilemmal) cyst component may be adjacent to the more solid area of proliferating trichilemmal tumour. Cytological atypia and mitotic figures may be present in proliferating trichilemmal tumour, but do not necessarily denote malignancy 3 4 7. However, the presence of tumour necrosis, marked cytological atypia or an infiltrative border in the background of a proliferating trichilemmal tumour strongly suggests malignant transformation, also termed ‘malignant proliferating trichilemmal tumor’ which may locally recur and metastasise 53–57.…”

Section: Cutaneous Adnexal Tumours With Follicular Lineagementioning

confidence: 99%

“…The small nests and strands of basaloid cells may mimic infiltrative BCCs, but the presence of ductal differentiation is not a common feature of BCCs. Perineural invasion is more commonly seen in MACs, which lacks peripheral palisading, myxoid stroma and peripheral clefting, features typical of BCC 1–3 7…”

Section: Cutaneous Adnexal Tumours Derived From Sweat Glandsmentioning

confidence: 99%

“…The malignant cutaneous adnexal tumours arise de novo or occur in association with a benign component. Some of the malignant adnexal tumours feature high rates of local recurrence, distant metastases and overall poor outcomes 7. For example digital papillary adenocarcinoma (DPAC) has a 50% recurrence rate, with a 14% risk of metastasis (especially to lung),8 sebaceous carcinoma (SC) shows an overall 25% risk of lymph node or distant metastasis,9 and porocarcinoma is reported to have a 20% risk of local recurrence and metastatic rate 10 11.…”

Section: Introductionmentioning

confidence: 99%

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Challenges in the diagnosis of cutaneous adnexal tumours

et al. 2015

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The diagnosis of cutaneous adnexal neoplasms, a heterogeneous group of entities, is often perceived by practising pathologists as challenging. A systematic approach to diagnosis is necessary for classification of these lesions, which establishes the tumour differentiation (follicular, sebaceous, sweat gland or apocrine) and evaluates histological features differentiating between benign and malignant entities. Consideration of clinical history is a necessary adjunct in evaluation of the adnexal neoplasm, as characteristic anatomical sites are described for many adnexal lesions. In some instances, immunohistochemical studies may also be employed to aid the diagnosis. The differential diagnosis between primary cutaneous adnexal neoplasms and cutaneous metastases from visceral tumours may also be difficult. Clinical, radiological, histological and immunohistochemical characteristics will be further discussed, considering that the correct diagnosis has a significant impact on the patient's management and prognosis.

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“…Finally, while BCCs show occasional mitotic figures and apoptosis, they may be absent in TEs (table 1). 3 4 7…”

Section: Cutaneous Adnexal Tumours With Follicular Lineagementioning

confidence: 99%

Section: Cutaneous Adnexal Tumours With Follicular Lineagementioning

confidence: 99%

Section: Cutaneous Adnexal Tumours Derived From Sweat Glandsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Challenges in the diagnosis of cutaneous adnexal tumours

et al. 2015

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“…Weedon comments that the diagnosis of KA can be difficult for the inexperienced pathologist 1. Phillip McKee, another expert, on the other hand, holds an opposing view believing that KA is an SCC variant at the low-grade end of a malignant spectrum 2. The purpose of this survey was to get an insight into regional variation in the diagnosis of KA, and to summarise personal communications from colleagues that influenced their diagnostic choices.…”

Section: Introductionmentioning

confidence: 99%

Histopathologists’ approach to keratoacanthoma: a multisite survey of regional variation in Great Britain and Ireland

Carr

Houghton

2014

J Clin Pathol

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Association of Histologic Regression With a Favorable Outcome in Patients With Stage 1 and Stage 2 Cutaneous Melanoma

et al. 2021

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IMPORTANCEAlthough regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis. OBJECTIVE To determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma. DESIGN, SETTING, AND PARTICIPANTSThis cohort study analyzed data from 2 large cohorts of adults (one in the Netherlands and the other in Australia) with histologically proven, stage 1 and 2 primary, invasive cutaneous melanoma with known regression status treated between 2000 and 2014, with median follow-up times of 4.5 and 11.1 years for the Dutch and Australian cohorts, respectively. For the Dutch patients, population-based data from PALGA, the Dutch Pathology Registry, were used, and follow-up data were retrieved from the Netherlands Cancer Registry. For the Australian patients, data from the database of a large, specialized melanoma treatment center were used.MAIN OUTCOMES AND MEASURES Multivariable Cox proportional hazards analyses were performed per cohort to assess recurrence-free survival (RFS) and overall survival (OS), and subgroup analyses according to Breslow thickness category and melanoma subtype were performed.RESULTS A total of 17 271 Dutch patients and 4980 Australian patients were included. In both cohorts, survival outcomes were better for patients with disease regression. For Dutch patients, the hazard ratio (HR) for those with disease regression was 0.55 (95% CI, 0.48-0.63; P < .001) for RFS and 0.87 (95% CI, 0.79-0.96; P = .004) for OS; for the Australian patients, the HR was 0.61 (95% CI, 0.52-0.72; P < .001) for RFS and 0.73 (95% CI, 0.64-0.84; P < .001) for OS. Subgroup analyses showed that the presence of regression improved RFS within thin and intermediate Breslow thickness melanomas in both cohorts. For patients with superficial spreading melanoma (SSM) subtype, regression improved RFS and OS in both cohorts. For Dutch patients with SSM, the HR for those with disease regression was 0.54 (95% CI, 0.46-0.63; P < .001) for RFS and 0.86 (95% CI, 0.76-0.96; P = .009) for OS; for the Australian patients with SSM, the HR was 0.67 (95% CI, 0.52-0.85; P = .001) for RFS and 0.72 (95% CI, 0.59-0.88; P = .001) for OS. CONCLUSIONS AND RELEVANCEIn 2 large patient cohorts from 2 different continents, regression was a favorable prognostic factor for patients with stage 1 and 2 melanomas, especially in those with thin and intermediate thickness tumors and those with SSM subtype.

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Cutaneous cysts

Cited by 80 publications

References 286 publications

Challenges in the diagnosis of cutaneous adnexal tumours

Challenges in the diagnosis of cutaneous adnexal tumours

Histopathologists’ approach to keratoacanthoma: a multisite survey of regional variation in Great Britain and Ireland

Association of Histologic Regression With a Favorable Outcome in Patients With Stage 1 and Stage 2 Cutaneous Melanoma

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