Cutaneous deciduosis

Abstract

Cutaneous deciduosis is an exceedingly rare manifestation of endometriosis potentially mistaken for malignancy and thus far documented solely within surgical scars. We describe two additional cases, one occurring in a pregnant 21-year-old woman as a solitary flat erythematous vulvar papule, an extraordinary location not previously recorded. Histologic examination in that case revealed a subepithelial nodular aggregate of atypical large dyscohesive cells with accompanying edema and inflammation. An immunohistochemical panel showed positivity of the cells for vimentin and Ki-1 (CD30). Intracellular sulfated mucin and glycogen were also demonstrated. In a second case, a 27-year-old woman had a nodule at the umbilicus, removed incidentally during the course of cesarean section. Microscopically there were several circumscribed, multilobulated, intradermal nodules with variably sized lumens formed by crowded large epithelioid cells. The disparate histologic appearance of these examples highlights an essential challenge in their diagnosis. Clinical recognition is difficult unless suggested by more characteristic history or location.

Morphological variations of scar-related and spontaneous endometriosis of the skin and superficial soft tissue: A study of 71 cases with emphasis on atypical features and types of müllerian differentiations

“…[25][26][27][28] Its incidence in the Steck and Helwig series 2 was 9 of 82, while we have observed only one case among our 71 patients. Decidualized endometrium is due to the influence of ovarian and placental hormones, principally progesterone; thus it is commonly encountered in histologic specimens obtained during pregnancy or progestin therapy.…”

Ectopic Decidual Reaction: A Case Report

“…The deciduosis cells showed immunohistochemical positivity for vimentin and Ki-1 (CD30). Intracellular sulfated mucin and glycogen were demonstrated [6].…”

Decidualização Ectópica: Uma Entidade Esquecida

“…58 Na deciduose ovárica, a ecografia pélvica mostra espessamento do estroma com neovascularização, de natureza papilar, mimetizando os achados ultrassonográficos sugestivos de malignidade. 40 Nestes casos, na ressonância magnética a lesão ovárica de deciduose apresenta caracteristicamente isointensidade com a placenta, auxiliando a diferenciação Tabela 3 -Painel dos principais anticorpos usados na técnica de imunohistoquímica para diagnóstico diferencial 20,22,33,34,38,50,59,61,75 entre decidualização e malignidade.…”