Cutaneous drug Reactions: Chemotherapy-induced hyperpigmentation

Hernandez-Aragues, Ignacio; Baniandrés‐Rodríguez, Ofelia; Vilas-Boas, Pedro; Conde-Montero, Elena; Suárez‐Fernández, Ricardo

doi:10.1684/ejd.2017.3180

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…[11] Post-chemotherapy hyperpigmentation can be a temporary or long-term side effect of chemotherapy, depending on the individual and the drugs used for treatment. [13] In most cases, hyperpigmentation fades over time; however, it can take several months or even years for the skin to return to its normal color. However, this study examined an alternative option to solve the problem of hyperpigmentation affecting the QOL.…”

Section: Discussionmentioning

confidence: 99%

Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports

Chiu

Hsiao

et al. 2023

Medicine

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Rationale: This study aimed to evaluate the efficacy of topical application of Aloe vera gel in preventing chemotherapy-induced hyperpigmentation (CIH). CIH is a common side effect of chemotherapy that causes skin irritation, redness, and itching. Aloe vera has been studied for its potential use in treating radiation-induced dermatitis, which may help alleviate some of the symptoms associated with this condition.Patient concerns: In this study, 4 children requiring curative chemotherapy were prospectively enrolled and treated with Aloe vera gel.Diagnosis: Acute skin reactions were monitored and classified according to the Common Terminology Criteria for Adverse Events Grading Scale.Interventions: Patients were asked to use the gel on one-half of the body field twice daily from the beginning of treatment until 4 weeks after the completion of chemotherapy, with no medication to be used on the other half.Outcomes: The results indicate that applying Aloe vera gel may reduce the visibility of hyperpigmentation at subsequent time points. The most important observation was that the continued application of Aloe vera gel 4 weeks after the completion of chemotherapy was effective in reducing the grading of CIH.Lessons: These effects highlight the potential of Aloe vera gel as a topical onconutraceutical treatment for CIH.Abbreviations: CIH = chemotherapy-induced hyperpigmentation, QOL = quality of life.

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Section: Discussionmentioning

confidence: 99%

Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports

Chiu

Hsiao

et al. 2023

Medicine

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“…The hyperpigmentation could be the result of postinflammatory lesions but also may be related to the increased sensitivity to sunlight. Additionally, it should be noted that hyperpigmentation can also be induced by some chemotherapy agents (for example cyclophosphamide, doxorubicin, fluorouracil, busulfan) [21]. However, in such circumstances it typically disappears after 3 months without treatment [21].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it should be noted that hyperpigmentation can also be induced by some chemotherapy agents (for example cyclophosphamide, doxorubicin, fluorouracil, busulfan) [21]. However, in such circumstances it typically disappears after 3 months without treatment [21].…”

Section: Discussionmentioning

confidence: 99%

Epidermal barrier function in patients after allogeneic hematopoietic stem cell transplantation – a pilot study

Polańska¹,

Łojko‐Dankowska²,

Czyż³

et al. 2022

pdia

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Introduction:The skin is the typically and predominantly affected organ in patients after allogeneic hematopoietic stem cell transplantation (alloHSCT). The supportive therapy in patients after alloHSCT includes especially ultraviolet protection and the use of emollients. Aim: Due to the lack of studies regarding epidermal barrier function in patients with alloHSCT, our aims were to monitor dermatologically patients 1 year after the procedure with special emphasis on epidermal barrier function and to evaluate the properties of epidermal barrier function in patients with confirmed chronic GvHD (cGvHD). Material and methods: Our pilot study included 30 patients after alloHSCT and 20 healthy controls. In the group of patients after alloHSCT there were 10 individuals who were monitored dermatologically (including evaluation of skin, mucosae, nails and hair) within 1 year after the procedure (subgroup 1) and 20 patients with previously confirmed cGvHD (subgroup 2). We evaluated transepidermal water loss (TEWL), skin hydration and skin color. The clinical assessment and all noninvasive evaluations in patients included in subgroup 1 were performed before (at baseline) and 3, 6, 9 and 12 months after the procedure, while in subgroup 2 they were performed once. Results: In subgroup 1 we did not observe significant differences between baseline results and periods of assessments in TEWL values or corneometry, erythema and melanin measurements. In subgroup 2 the highest TEWL values and the lowest corneometry results were observed in patients with sclerodermoid chronic cutaneous GvHD in comparison to patients with lichenoid chronic cutaneous GvHD and patients with cGvHD but without skin lesions. TEWL values and melanin level were significantly higher in patients with cGvHD than in controls. Conclusions: Our pioneer observations proved the disturbed epidermal barrier function among patients after al-loHSCT. Therefore it seems that proper skin care, including photoprotection, should be recognized as a crucial component in long-term management of these patients.

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“…Other less common lesions are epidermal nevus, ichthyosis hystrix, verruca vulgaris, actinic keratosis, other precancerous keratosis, seborrheic keratosis, molluscum contagiosum, trichilemmal cysts or epidermoid cysts. 2,3 Malignant transformation into squamous cell carcinoma has been reported to occur in around 20 to 25% of cases. 3 The diagnosis is clinical but histopathology is important to identify the underlying lesion.…”

Section: Cutaneous Horn Overlying Verrucous Carcinoma On Face and Its Dermoscopic Characterizationmentioning

confidence: 99%

“…Several patterns of chemotherapy-induced cutaneous hyperpigmentation have been described, namely diffuse (busulfan, cyclophosphomide), palmoplantar (5-fluorouracil, ifosfamide, tegafur), flagellate (bleomycin) and supravenous (5-fluorouracil) and at the sites of trauma or friction (cyclophosphamide, fluorouracil, thiotepa). 1,2 Chemotherapyinduced reticulate pigmentation is a rare entity with only a few cases described in the literature. 3,4 We were unable to find any report either in the pediatric age group or in Indian patients.…”

mentioning

confidence: 99%

Chemotherapy-induced reticulate pigmentation in three Indian patients including a case in the pediatric age group

Kumar

Bhattacharjee

Kambhampati

et al. 2021

IJDVL

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Cutaneous drug Reactions: Chemotherapy-induced hyperpigmentation

Cited by 6 publications

References 6 publications

Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports

Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports

Epidermal barrier function in patients after allogeneic hematopoietic stem cell transplantation – a pilot study

Chemotherapy-induced reticulate pigmentation in three Indian patients including a case in the pediatric age group

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