Cutaneous EBV-related lymphoproliferative disorders

Gru, Alejandro A.; Jaffe, Elaine S.

doi:10.1053/j.semdp.2016.11.003

Cited by 49 publications

(63 citation statements)

References 206 publications

(241 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CD30 is occasionally positive, and some patients may be CD4+ or CD4‐/CD8‐. CD5, CD7, CD43, and CD25 expression is often variable . Positivity of CD30 and CD56 are more frequently seen in biopsies with an NK‐cell phenotype, which tends to involve the subcutaneous tissue.…”

Section: Discussionmentioning

confidence: 99%

“…CD5, CD7, CD43, and CD25 expression is often variable. 19 Positivity of CD30 and CD56 are more frequently seen in biopsies with an NK-cell phenotype, which tends to involve the subcutaneous tissue. In this phenotype, the neoplastic cells surround individual fat cells and may appear like subcutaneous panniculitis T-cell lymphoma histologically.…”

Section: Histopathological Featuresmentioning

confidence: 99%

See 1 more Smart Citation

Hydroa vacciniforme‐like lymphoproliferative disorder in an elderly Chinese patient and a literature review of adult cases

2018

View full text Add to dashboard Cite

Hydroa vaccinforme-like lymphoproliferative disorder (HVLPD) is a rare T-cell lymphoproliferative disorder driven by the Epstein-Barr Virus (EBV). It was initially designated under the 2008 WHO classification of tumors of hematopoietic and lymphoid tissues as a distinct entity but has been recently reclassified as a lymphoproliferative disorder under the 2016 revision of the 2008 WHO classification of lymphoid malignancies. HVLPD mainly affects Asian, Central, and South American children. It is rarely seen in adults. Although HVLPD may initially be limited to cutaneous involvement and run an indolent course, some patients may develop a rapidly aggressive course. We report a case of an elderly Chinese man with cutaneous-limited disease and a favorable course. A review of adult cases of HVLPD published in the English literature, with comparison to our case, is also presented in this paper.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Histopathological Featuresmentioning

confidence: 99%

Hydroa vacciniforme‐like lymphoproliferative disorder in an elderly Chinese patient and a literature review of adult cases

2018

View full text Add to dashboard Cite

show abstract

“…The most reliable marker in those patients is the identification of EBV. 97 The EBV blood levels by polymerase chain reaction correlate strongly with the patient's outcome. Treatment for them is based on the combination of radiation and systemic chemotherapy (SMILE) regimen.…”

mentioning

confidence: 99%

“…A papular and vesicular eruption with scarring, with associated photosensitivity, in children of South America, Central America, and Mexico, in association with EBV infection, is the more classic clinical picture of HV-LPD. 46,[97][98][99][100] The clinical papular presentation is also typical of marginal zone lymphomas. As opposed to PCFCL, which presents in the head and neck area, CMZL is more frequent in the extremities and lower trunk.…”

mentioning

confidence: 99%

A Systematic Approach to the Cutaneous Lymphoid Infiltrates: A Clinical, Morphologic, and Immunophenotypic Evaluation

Gru

McHargue

Salavaggione

2019

Archives of Pathology &Amp; Laboratory Medicine

Self Cite

View full text Add to dashboard Cite

Context.— The evaluation of cutaneous lymphoid infiltrates, both neoplastic and inflammatory, occurs very frequently in routine dermatopathologic examination and consultation practices. The “tough” cutaneous lymphoid infiltrate is feared by many pathologists; skin biopsies are relatively small, whereas diagnostic possibilities are relatively broad. It is true that cutaneous lymphomas can be difficult to diagnose and that in many circumstances multiple biopsies are required to establish a correct diagnostic interpretation. As a reminder, one should understand that low-grade cutaneous lymphomas are indolent disorders that usually linger for decades and that therapy does not result in disease cure. It is also important to remember that in most circumstances, those patients will die from another process that is completely unrelated to a diagnosis of skin lymphoma (even in the absence of specific therapy). Objective.— To use a clinicopathologic, immunophenotypic, and molecular approach in the evaluation of common lymphocytic infiltrates. Data Sources.— An in-depth analysis of updated literature in the field of cutaneous lymphomas was done, with particular emphasis on updated terminology from the most recent World Health Organization classification of skin and hematologic tumors. Conclusions.— A diagnosis of cutaneous lymphoid infiltrates can be adequately approached using a systematic scheme following the proposed ABCDE system. Overall, cutaneous T- and B-cell lymphomas are rare and “reactive” infiltrates are more common. Evaluation of lymphoid proliferations should start with a good sense of knowledge of the clinical presentation of the lesions, the clinical differential considerations, and a conscientious and appropriate use of immunohistochemistry and molecular tools.

show abstract

“…Cytomorphological characteristics and the immunophenotype show signifi cant overlap with cutaneous Hodgkin's lymphoma [ 5,8 ] . Cytomorphological characteristics and the immunophenotype show signifi cant overlap with cutaneous Hodgkin's lymphoma [ 5,8 ] .…”

mentioning

confidence: 99%