Cutaneous Histologic Features in Ehlers-Danlos Syndrome

Sulica, Virginia I.

doi:10.1001/archderm.1979.04010010012004

Cited by 30 publications

(1 citation statement)

References 17 publications

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“…The Ehlers-Danlos syndrome affects the collagen network, leading to fragility and hyperextensibility of the skin [7]. The diseased microstructure shows loose, sparse, and disordered dermal collagen network with increased number of elastic fibers [8]. Systemic sclerosis, an auto-immune inflammatory disease, results in skin fibrosis, in addition to numerous other symptoms [9].…”

Section: Introductionmentioning

confidence: 99%

On the Reliability of Suction Measurements for Skin Characterization

Mueller

Elrod

Distler

et al. 2020

Journal of Biomechanical Engineering

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In-vivo skin characterization methods were shown to be useful in detection of microstructural alterations of the dermis due to skin diseases. Specifically the diagnostic potential of skin suction has been widely explored, yet measurement uncertainties prevented so far its application in clinical assessment. In the present work, we analyse specific factors influencing the reliability of suction measurements. We recently proposed a novel suction device, called Nimble, addressing the limitations of existing instruments, and applied it in clinical trials quantifying mechanical differences between healthy skin and scars. Measurements were performed with the commercial device Cutometer and with the new device. A set of new suction measurements was carried out on scar tissue and healthy skin and FE-based inverse analysis was applied to determine corresponding parameters of a hyperelastic-viscoelastic material model. FE simulations were used to rationalize differences between suction protocols and to analyse specific factors influencing the measurement procedure. Tissue stiffness obtained from Cutometer measurements was significantly higher compared to the one from Nimble measurements, which was shown to be associated with the higher deformation levels in the Cutometer and the non-linear mechanical response of skin. The effect of the contact force exerted on skin during suction measurements was quantified, along with an analysis of the effectiveness of a corresponding correction procedure. Parametric studies demonstrated the inherently higher sensitivity of displacement- over load-controlled suction measurements, thus rationalizing the superior ability of the Nimble to distinguish between tissues.

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Section: Introductionmentioning

confidence: 99%

On the Reliability of Suction Measurements for Skin Characterization

Mueller

Elrod

Distler

et al. 2020

Journal of Biomechanical Engineering

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The Invisible Dermatoses

Kligman¹

1991

Arch Dermatol

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The central tenet of invisible dermatology is that visible lesions represent a late stage of development. The eye is an unreliable instrument for judging the normalcy of skin. In chronic widespread dermatoses, the uninvolved skin is at least physiologically abnormal. Recently healed skin is always abnormal. Recognition of occult changes will have a substantial impact on the prevention and treatment of diseases of the skin.

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Disorders of Connective Tissue

Burrows¹,

Lovell²

2004

Rook's Textbook of Dermatology

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Cutaneous Histologic Features in Ehlers-Danlos Syndrome

Cited by 30 publications

References 17 publications

On the Reliability of Suction Measurements for Skin Characterization

On the Reliability of Suction Measurements for Skin Characterization

The Invisible Dermatoses

Disorders of Connective Tissue

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