Cutaneous infection due to<i>Mycobacterium interjectum</i>in an immunosuppressed patient with microscopic polyangiitis

Fukuoka, Masashi; Matsumura, Yutaka; Kore-Eda, Satoshi; Iinuma, Yoshitsugu

doi:10.1111/j.1365-2133.2008.08867.x

Cited by 8 publications

(9 citation statements)

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“…Environmental mycobacteria or MOTT include a large number of species that can cause serious illnesses in humans, particularly in immunocompromised patients [27]. For example, Mycobacterium interjectum has been identified as a causative agent of cervical lymphadenitis in children [28], and of cutaneous infections in immunosuppressed patients [29]. M. xenopi may cause pulmonary disease in humans [30], and M. scrofulaceum may cause cutaneous infections and lymphadenitis [27].…”

Section: Introductionmentioning

confidence: 99%

“…M. xenopi may cause pulmonary disease in humans [30], and M. scrofulaceum may cause cutaneous infections and lymphadenitis [27]. In humans, risk factors for MOTT infections include immunosuppression, contaminated water and aerosol exposure, and short or old age [27-29]. MOTT are widely distributed in the environment, particularly in wet soil, marshland, streams, rivers and estuaries, but each species shows different preferences [31].…”

Section: Introductionmentioning

confidence: 99%

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Fine-tuning the space, time, and host distribution of mycobacteria in wildlife

et al. 2011

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BackgroundWe describe the diversity of two kinds of mycobacteria isolates, environmental mycobacteria and Mycobacterium bovis collected from wild boar, fallow deer, red deer and cattle in Doñana National Park (DNP, Spain), analyzing their association with temporal, spatial and environmental factors.ResultsHigh diversity of environmental mycobacteria species and M. bovis typing patterns (TPs) were found. When assessing the factors underlying the presence of the most common types of both environmental mycobacteria and M. bovis TPs in DNP, we evidenced (i) host species differences in the occurrence, (ii) spatial structuration and (iii) differences in the degree of spatial association of specific types between host species. Co-infection of a single host by two M. bovis TPs occurred in all three wild ungulate species. In wild boar and red deer, isolation of one group of mycobacteria occurred more frequently in individuals not infected by the other group. While only three TPs were detected in wildlife between 1998 and 2003, up to 8 different ones were found during 2006-2007. The opposite was observed in cattle. Belonging to an M. bovis-infected social group was a significant risk factor for mycobacterial infection in red deer and wild boar, but not for fallow deer. M. bovis TPs were usually found closer to water marshland than MOTT.ConclusionsThe diversity of mycobacteria described herein is indicative of multiple introduction events and a complex multi-host and multi-pathogen epidemiology in DNP. Significant changes in the mycobacterial isolate community may have taken place, even in a short time period (1998 to 2007). Aspects of host social organization should be taken into account in wildlife epidemiology. Wildlife in DNP is frequently exposed to different species of non-tuberculous, environmental mycobacteria, which could interact with the immune response to pathogenic mycobacteria, although the effects are unknown. This research highlights the suitability of molecular typing for surveys at small spatial and temporal scales.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine-tuning the space, time, and host distribution of mycobacteria in wildlife

et al. 2011

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“…M. interjectum has also been isolated in sputum cultures of asymptomatic patients [ 7 , 13 ] and from the gastrointestinal tract in a patient with acquired immunodeficiency syndrome [ 14 ]. In adults, infection with M. interjectum has been reported with pulmonary infection [ 5 , 15 , 16 ], cutaneous infection [ 17 ], and meningitis [ 18 ] ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

DisseminatedMycobacterium interjectumInfection with Bacteremia, Hepatic and Pulmonary Involvement Associated with a Long-Term Catheter Infection

Sotello

Hata

Reza

et al. 2017

Case Reports in Infectious Diseases

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We present a 49-year-old female with one year of intermittent fevers, chills, night sweats, and significant weight loss. Liver and lung biopsy showed evidence of a granulomatous process. Blood and liver biopsy cultures yielded growth of presumed Mycobacterium interjectum, thought to be related to a disseminated long-term central venous catheter infection. She successfully received one year of combined antimicrobial therapy after catheter removal without recurrence of disease. M. interjectum has been previously described as a cause of lymphadenitis in healthy children and associated with pulmonary disease in adults, although other localized infections have been reported. This is the first case described of a disseminated M. interjectum infection with bacteremia, hepatic and pulmonary involvement associated with a long-term catheter infection.

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“…It has also been isolated in the sputum of patients with chronic obstructive lung disease or HIV infection, in the urine of an asymptomatic elderly female, and in the stool of an AIDS patient with diarrhea [7, 8]. Fukuoka et al described a case of an immunosuppressed Japanese woman with polyangiitis who developed multiple cutaneous abscesses infected with M. interjectum requiring repeated surgical resection [9]. In one case of a female alcoholic patient with meningoencephalitis, the cerebrospinal fluid culture presented coisolation of M. malmoense and M. interjectum .…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium interjectumLung Infection

Mirant-Borde

Álvarez

Johnson

2013

Case Reports in Pulmonology

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A 62-year-old male presented with productive cough, weight loss, and night sweats. CXR revealed a right upper lobe cavitary lesion. Evaluation was negative for Mycobacterium tuberculosis, and sputum revealed Mycobacterium avium intracellulare (MAI). Since his clinical course was atypical for MAI, further investigations were pursued which identified Mycobacterium interjectum in lung specimens, a very rarely described etiology of pulmonary disease. Appropriate therapy with rifampin, intravenous amikacin, trimethoprim/sulfamethoxazole (TMP/SMX), and ethambutol resulted in clinical and radiographic improvement. This is the third case described over a period of 20 years of destructive lung disease in an immunocompetent adult due to M. interjectum.

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Cutaneous infection due toMycobacterium interjectumin an immunosuppressed patient with microscopic polyangiitis

Cited by 8 publications

References 9 publications

Fine-tuning the space, time, and host distribution of mycobacteria in wildlife

Fine-tuning the space, time, and host distribution of mycobacteria in wildlife

DisseminatedMycobacterium interjectumInfection with Bacteremia, Hepatic and Pulmonary Involvement Associated with a Long-Term Catheter Infection

Mycobacterium interjectumLung Infection

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