Cutaneous infection with Alternaria tenuissima in an immunocompromised patient

Robertshaw, H.; Higgins, E. M.

doi:10.1111/j.1365-2133.2005.06833.x

Cited by 25 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, administration of PPARc agonists to psoriatic patients associates with amelioration of symptoms and skin lesions (Table S1). The systemic administration of troglitazone and pioglitazone improved skin lesions in psoriatic patients (52)(53)(54)(55), whereas rosiglitazone was ineffective either systemically or topically underlining how different ligands lead to diverse biological effects (56,57).…”

Section: Psoriasismentioning

confidence: 99%

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

Ramot

Mastrofrancesco

Camera

et al. 2015

Experimental Dermatology

View full text Add to dashboard Cite

Yuval Ramot and Arianna Mastrofrancesco contributed equally to this work.Abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that modulate the expression of multiple different genes involved in the regulation of lipid, glucose and amino acid metabolism. PPARs and cognate ligands also regulate important cellular functions, including cell proliferation and differentiation, as well as inflammatory responses. This includes a role in mediating skin and pilosebaceous unit homoeostasis: PPARs appear to be essential for maintaining skin barrier permeability, inhibit keratinocyte cell growth, promote keratinocyte terminal differentiation and regulate skin inflammation. They also may have protective effects on human hair follicle (HFs) epithelial stem cells, while defects in PPARc-mediated signalling may promote the death of these stem cells and thus facilitate the development of cicatricial alopecia (lichen planopilaris). Overall, however, selected PPARc modulators appear to act as hair growth inhibitors that reduce the proliferation and promote apoptosis of hair matrix keratinocytes. The fact that commonly prescribed PPARc-modulatory drugs of the thiazolidine-2,4-dione class can exhibit a battery of adverse cutaneous effects underscores the importance of distinguishing beneficial from clinically undesired cutaneous activities of PPARc ligands and to better understand on the molecular level how PPARc-regulated cutaneous lipid metabolism and PPARcmediated signalling impact on human skin physiology and pathology. Surely, the therapeutic potential that endogenous and exogenous PPARc modulators may possess in selected skin diseases, ranging from chronic inflammatory hyperproliferative dermatoses like psoriasis and atopic dermatitis, via scarring alopecia and acne can only be harnessed if the complexities of PPARc signalling in human skin and its appendages are systematically dissected.

show abstract

Section: Psoriasismentioning

confidence: 99%

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

Ramot

Mastrofrancesco

Camera

et al. 2015

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8] Alternaria produces melanin and is considered a dematiaceous, or pigmented, fungus, exhibiting a characteristic macroscopic brown pigmentation in some extraocular infections. 9 Although dematiaceous fungi are less commonly associated with ocular infections than moniliaceous or nonpigmented fungi, 10 as a class, they are considered more resistant to medical therapy and respond differently to available antifungals. Prior experience with Alternaria keratitis, specifically, has been variable ranging from penetrating keratoplasty to medical cure but with a variable response to a variety of topical and/or systemic antifungals.…”

mentioning

confidence: 99%

Alternaria Keratitis: Clinical Presentation and Resolution With Topical Fluconazole or Intrastromal Voriconazole and Topical Caspofungin

2009

Cornea

View full text Add to dashboard Cite

Alternaria keratitis has a varied clinical presentation and may present without macroscopic pigmentation. In vitro sensitivity testing may be helpful in directing therapy for Alternaria keratitis, but clinical response should be monitored as the primary endpoint. Response to natamycin was poor, but successful resolution with topical fluconazole or intrastromal voriconazole and topical caspofungin with preservation of good visual acuity was possible.

show abstract

“…[131] Therefore, topically applicable PPAR-γ modulators would be perferred for treating hair disorders, if they can be shown to be sufficiently effective. However, so far, the use of topical PPAR-γ modulators, such as rosiglitazone, for skin conditions (eg psoriasis) was not successful in clinical studies in humans, [132] and it is expected to be even more difficult when targeting the HF.…”

mentioning

confidence: 99%

PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology

Ramot

Bertolini

Boboljova

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

Peroxisome proliferator‐activated receptors (PPARs) are abundantly expressed in human skin, with PPAR‐γ being the most intensively investigated isoform. In various ex vivo and in vivo models, PPAR‐γ‐mediated signalling has recently surfaced as an essential element of hair follicle (HF) development, growth and stem cell biology. Moreover, the availability of novel, topically applicable PPAR‐γ modulators with a favourable toxicological profile has extended the range of potential applications in clinical dermatology. In this review, we synthesize where this field currently stands and sketch promising future research avenues, focussing on the role of PPAR‐γ‐mediated signalling in the biology and pathology of human scalp HFs, with special emphasis on scarring alopecias such as lichen planopilaris and frontal fibrosing alopecia as model human epithelial stem cell diseases. In particular, we discuss whether and how pharmacological modulation of PPAR‐γ signalling may be employed for the management of hair growth disorders, for example, in scarring alopecia (by reducing HF inflammation as well as by promoting the survival and suppressing pathological epithelial‐mesenchymal transition of keratin 15 + epithelial stem cells in the bulge) and in hirsutism/hypertrichosis (by promoting catagen development). Moreover, we explore the potential role of PPAR‐γ in androgenetic alopecia, HF energy metabolism and HF ageing, and consider clinical perspectives that emanate from the limited data available on this so far. As this field of translational human hair research is still in its infancy, many open questions exist, for which we briefly delineate selected experimental approaches that promise to generate instructive answers in the near future.

show abstract

Cutaneous infection with Alternaria tenuissima in an immunocompromised patient

Cited by 25 publications

References 9 publications

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

Alternaria Keratitis: Clinical Presentation and Resolution With Topical Fluconazole or Intrastromal Voriconazole and Topical Caspofungin

PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology

Contact Info

Product

Resources

About