Cutaneous infection with Mycobacterium abscessus

Abstract

Summary Cutaneous infection with rapidly growing mycobacteria is uncommon and diagnosis may be difficult. However, the histopathological features are distinctive and may aid diagnosis. The three pathogenic species, Mycobacterium fortuitum, M. chelonae and M. abscessus, show major differences in their antimicrobial sensitivities, and species identification is therefore important. We describe a case of infection with M. abscessus, and discuss the clinical and pathological features of such infections, and approaches to their treatment.

Subcutaneous Infection with <i>Mycobacterium</i><i>abscessus</i> in a Renal Transplant Recipient

“…However, M. abscessus is mostly resistant to conventional antituberculous drugs. Good results of improvement and recovery could be achieved by treatment with clarithromycin (2 × 250 mg/day) and ciprofloxacin (2 × 250 mg/day) [14]. The complete remission after antibiotic therapy in our patient demonstrates that cutaneous M. abscessus infections may respond well to antibiotic treatment alone, but long-term treatment over a period of 9–12 months is required.…”

Mycobacterium abscessus Infections in Lung Transplant Recipients: The International Experience

“…14 Antibiotic monotherapy may produce resistance; therefore, combination therapy is recommended. 15,16 Prolonged therapy is often required to achieve microbiologic cure or radiologic improvement, particularly in cases of disseminated disease. 9,12 Despite existing guidelines of 4 to 6 months for immunocompetent individuals, the optimal minimum duration of therapy in transplant recipients is not clear.…”

Sporotrichoide atypische Mykobakterien

“…B. M. marinum) Vorteile bietet. Nachteile der PCR-Technik sind die hohen Kosten und die fehlende Standardisierung [5,10].…”

“…Bei unserer Patientin (Fall 3) hatte Clarithromycin zur Heilung geführt, ein Rezidiv trat nicht auf. Es liegen jedoch auch mehrere Berichte von primären und sich während der Therapie entwickelnden Resistenzen von M. chelonae gegen Clarithromycin vor [2,6].Manche Autoren raten bei dem Nachweis von Erregern aus dem MFK prinzipiell zu einer Kombinationstherapie,z.B.Clarithromycin und Ciprofloxacin [10]. Die Mindestdauer der Therapie beträgt 3 Monate.…”