Cutaneous Infection with Mycobacterium fortuitum after Localized Microinjections (Mesotherapy) Treated Successfully with a Triple Drug Regimen

Nagore, Eduardo; Ramos, Pilar Cejudo; Botella‐Estrada, Rafael; Ramos-Niguez, J. A.; Sanmartín, O.; Castejón, Pilar

doi:10.1080/00015550152572967

Cited by 69 publications

(52 citation statements)

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“…However, the study observations are consistent with previous reports in the characteristics of clinical lesions and the isolated microorganism. 2,4 The present research suggests a potential association between mesotherapy injections and persistent cutaneous abscesses in Lima, and warrant considerations on the safety of mesotherapy practices.…”

Section: Discussionmentioning

confidence: 99%

Outbreak of persistent cutaneous abscesses due to Mycobacterium chelonae after mesotherapy sessions, Lima, Peru

et al. 2008

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Outbreak of persistent cutaneous abscesses due to Mycobacterium chelonae after mesotherapy sessions, Lima, Peru Surto de abscessos cutâneos persistentes por Mycobacterium chelonae pós-mesoterapia, Lima, Peru ABSTRACT Outbreaks of rapidly growing mycobacteria have been occasionally described. The article reports an outbreak of cutaneous abscesses due to Mycobacterium chelonae following mesotherapy in Lima, Peru. From December 2004 through January 2005, 35 subjects who had participated in mesotherapy training sessions presented with persistent cutaneous abscesses. Thirteen (37%) of these suspected cases consented to underwent clinical examination. Skin punch-biopsies were collected from suspicious lesions and substances injected during mesotherapy were analyzed. Suspected cases were mainly young women and lesions included subcutaneous nodules, abscesses and ulcers. Mycobacterium chelonae was isolated from four patients and from a procaine vial. In conclusion, it is important to consider mesotherapy as a potential source of rapidly growing mycobacteria infections. Although rapidly growing mycobacteria (RGM) are ubiquitous, diseases caused by these atypical bacteria are relatively uncommon. 1 Among RGM, Mycobacterium chelonae is particularly prominent. Clinical diseases caused by this agent include cutaneous infections ranging from localized cellulitis to osteomyelitis. The precise burden of disease caused by this microorganism is unknown and most available information comes from occasional case reports. Cutaneous infections caused by RGM, including M. chelonae, have been associated with penetrating cutaneous trauma. Common procedures related to RGM-related infections included injections, liposuction, acupuncture and, more rarely, catheter insertions. 1

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Section: Discussionmentioning

confidence: 99%

Outbreak of persistent cutaneous abscesses due to Mycobacterium chelonae after mesotherapy sessions, Lima, Peru

et al. 2008

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“…The most feared and most often reported complication is mycobacterial infection, which requires months of treatment with multiple drugs and generally results in unaesthetic scars. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Apparently, secondary infections described in the aforementioned works can be explained by inadequate asepsis before the procedure or by contamination of the product being used.…”

Section: Literature Reviewmentioning

confidence: 99%

Mesoterapia: uma revisão bibliográfica

Herreros

Moraes²,

Velho³

2011

An. Bras. Dermatol.

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Intradermotherapy is a medical procedure introduced by Pistor in 1958 that consists in the application of intradermal injections of diluted pharmacological substances that are given directly into the region to be treated. There are reports of the use of intradermotherapy to treat painful diseases, skin diseases and unaesthetic conditions. Medical clinics have been recently offering the treatment of intradermotherapy, using the more popular name for this practice -mesotherapy. There is only scant scientific information about this subject published in periodicals indexed on MedLine. Only a few states rigorously pursue this method. Most indexed publications about this subject deal with the complications of this technique. Unaesthetic dermatoses have been a common complaint in dermatologic clinics, and it has become necessary to have scientific evidence to give to patients. Therefore, well-researched scientific studies about this technique are necessary to offer data to medical professionals that will clearly explain to patients both the benefits and the risks of these procedures. A bibliographical review was conducted and we verified the need for new studies with adequate methods to confirm the benefits of intradermotherapy as used in dermatologic treatment. Keywords: Injections, intradermal; Review; Skin; Therapeutics Resumo: A intradermoterapia é um procedimento médico introduzido por Pistor, em 1958, e consiste na aplicação, diretamente na região a ser tratada, de injeções intradérmicas de substâncias farmacológicas muito diluídas. Esse método é capaz de estimular o tecido que recebe os medicamentos tanto pela ação da punctura quanto pela ação dos fármacos, e apregoa-se que sua vantagem é evitar o uso de medicação sistê-mica. Há relatos da utilização da intradermoterapia para tratamento de doenças dolorosas, dermatoses e condições consideradas inestéticas. Atualmente, clínicas médicas oferecem esse tratamento, utilizando, porém, o nome mais popular para essa prática, mesoterapia. Há escassa informação científica sobre o tema publicada em periódicos indexados no MedLine e poucos estudos com metodologia mais rigorosa sobre a eficácia e o mecanismo de ação da via intradérmica. A maioria das publicações indexadas sobre esse tema versa sobre as complicações dessa técnica. As dermatoses inestéticas têm se tornado queixas frequentes nos consultórios dermatológicos, sendo necessário um embasamento científico para lidar com tais pacientes, os quais, muitas vezes, estão em busca das novidades mostradas através da mídia. Assim, há necessidade de estudos cientificamente bem conduzidos sobre essa técnica. Estes estudos deverão oferecer aos médicos elementos para esclarecer os pacientes sobre quais benefícios esperar e quais os riscos de tal abordagem. Desse modo, realizou-se uma revisão bibliográfica sobre o assunto e constatou-se a necessidade de novos estudos com metodologia adequada para a confirmação dos benefícios da intradermoterapia como ferramenta útil no tratamento dermatológico.

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“…Although most pathogenic species of NTM have been incriminated in skin and soft tissue infections, the rapidly growing mycobacteria (RGM)eMycobacterium fortuitum, M abscessus, and M chelonaeeare emerging as important causes of localized cutaneous infections in both sporadic cases and outbreak settings. 2 Infections with NTM have been described in association with Mohs micrographic surgery, 4 cutaneous surgery, 5 punch biopsy, 6 acupuncture, 7,8 mesotherapy, 9,10 injections, [11][12][13] cardiothoracic surgery, 14 breast reconstruction, 15 facial…”

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confidence: 99%