Cutaneous involvement by cytomegalovirus in a renal transplant recipient as an indicator of severe systemic infection

Neumann, Antonielle Borges Faria; Daxbacher, Egon Luiz Rodrigues; Chiaratti, Francielle Chiavelli; Jeunon, Thiago

doi:10.1590/abd1806-4841.20163989

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…Infections caused by multiple types of herpesviruses in patients with end-stage renal disease and transplant recipients have been constantly studied (34)(35) and the impacts that cytomegalovirus infection can cause to patients undergoing kidney TX have already been established in the literature. These infections are related to a considerable occurrence of graft dysfunction and rejection (36)(37)(38) , as observed in our study, suggesting also to consider this criterion for the stratification of infectious risk for this population.…”

Section: Discussionsupporting

confidence: 79%

Risk factors for colonization and infection by resistant microorganisms in kidney transplant recipients

et al. 2021

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Objectives: to assess the prevalence of colonization and infection by multidrug-resistant bacteria in patients undergoing kidney transplantation and identify the rate of infection, morbidity and mortality and associated risk factors. Methods: a prospective cohort of 200 randomly included kidney transplant recipients. Epidemiological surveillance of the studied microorganisms was carried out in the first 24 hours and 7 days after transplantation. Results: ninety (45%) patients were considered colonized. Female sex, hypertension and diabetes (p<0.005), dialysis time (p<0.004), length of stay after transplantation, delayed renal function, and length of stay were identified as risk factors. The microorganisms were isolated from surgical site, bloodstream and urinary tract infections. Conclusions: colonization by resistant microorganisms in kidney transplant patients was frequent and risk factors associated with infection were identified. The results should guide the care team in order to minimize morbidity and mortality related to infectious causes in this population.

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Section: Discussionsupporting

confidence: 79%

Risk factors for colonization and infection by resistant microorganisms in kidney transplant recipients

et al. 2021

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“…It has previously been reported in transplant patients [1,2], patients with congenital immunodeficiencies [3,4] and patients with autoimmune conditions on significant immunosuppression [5]. It generally occurs in the setting of disseminated infection [2]. In contrast, this patient had previously been treated for CMV retinitis and oesophageal ulcers, and had ongoing CMV viraemia, but did not have evidence of other organ involvement at the time of his cutaneous infection.…”

Section: Rash and Histopathology)mentioning

confidence: 74%

“…Cutaneous CMV is a rare manifestation of a common opportunistic pathogen and usually occurs in severely immunocompromised hosts. It has previously been reported in transplant patients [1,2], patients with congenital immunodeficiencies [3,4] and patients with autoimmune conditions on significant immunosuppression [5]. It generally occurs in the setting of disseminated infection [2].…”

Section: Rash and Histopathology)mentioning

confidence: 98%

A 44-year-old man with an ulcerating skin rash in the setting of advanced human immunodeficiency virus infection

MacPhail

McLean

Vujovic

et al. 2021

Aids

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A 44-year-old man with an ulcerating skin rash in the setting of advanced human immunodeficiency virus infection Cytomegalovirus (CMV) is a common opportunistic pathogen among immunocompromised patients. However, cutaneous manifestations are rare. We report a 44year-old man with an ulcerating skin rash secondary to cutaneous CMV infection in the setting of advanced, untreated HIV infection. A 44-year-old man diagnosed with advanced HIV in July 2011, with a CD4 cell count 4 (1%) cells/mL at diagnosis. He took antiretroviral therapy (ART) intermittently from July 2011 until January 2016 and has steadfastly declined ART and monitoring of HIV since then, being agreeable to symptomatic management only. He had Pneumocystis jirovecci pneumonia and CMV oesophagitis in July 2011, CMV retinitis involving both eyes in 2012-2013, resulting in bilateral blindness in spite of valganciclovir and intravitreal foscarnet treatment, which he ceased in January 2016. His CD4 cell count increased to 254 cells/ mL in December 2015, but was 4 (1%) in January 2017 off ART and prophylaxis. He experienced recurrent

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“…Human CMV infection is a severe complication in immunocompromised patients. Skin manifestations of this infection are very rare; maculopapules are the main manifestation on the skin, and ulcers, blisters, erosion, plaques, and nodules may also appear (32,33). The probability of skin abscesses is very low, and most of the lesions are located in the perianal, genital, and the surrounding areas (34).…”

Section: Discussionmentioning

confidence: 99%

IgM kappa proliferative glomerulonephritis with monoclonal immunoglobulin deposition complicated with nocardiosis dermatitis: a case report and review of literature

Chen,

Wang,

et al. 2024

Front. Med.

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RationaleMonoclonal gammopathy of renal significance (MGRS) represents a group of disorders caused by monoclonal immunoglobulin (M protein) secreted by B cells or plasma cells. Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID) is a glomerular disease and a form of MGRS. Here, we presented a rare case of a patient with IgM kappa PGNMID complicated with nocardiosis dermatitis.Patient concerns and diagnosesA 56-year-old man was admitted to the hospital because of cutaneous purpura and proteinuria. His initial pathological diagnosis indicated membranous proliferative glomerulonephritis, IgM(++), and subacute interstitial nephritis. Based on further examination, he was finally diagnosed to have IgM kappa PGNMID and subacute interstitial nephritis. After the initial diagnosis, the patient received hormonal therapy. During the treatment, nocardiosis dermatitis emerged as a complication, and the hormonal therapy was gradually reduced. The patient refused further treatment with rituximab, and his health is currently stable.OutcomesIgM kappa PGNMID complicated with nocardiosis dermatitis is an extremely rare occurrence. Laboratory examination and pathological analysis are required to confirm the diagnosis of this disorder. Timely and accurate diagnosis is essential for the appropriate treatment of PGNMID.

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Cutaneous involvement by cytomegalovirus in a renal transplant recipient as an indicator of severe systemic infection

Cited by 14 publications

References 11 publications

Risk factors for colonization and infection by resistant microorganisms in kidney transplant recipients

Risk factors for colonization and infection by resistant microorganisms in kidney transplant recipients

A 44-year-old man with an ulcerating skin rash in the setting of advanced human immunodeficiency virus infection

IgM kappa proliferative glomerulonephritis with monoclonal immunoglobulin deposition complicated with nocardiosis dermatitis: a case report and review of literature

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