1997
DOI: 10.1097/00000478-199711000-00011
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Cutaneous Involvement in Polyvinylpyrrolidone Storage Disease: A Clinicopathologic Study of Five Patients, Including Two Patients With Severe Anemia

Abstract: Polyvinylpyrrolidone (PVP), formerly a plasma expander, has continued to be inappropriately used in Taiwan for intravenous injection as a "blood tonic." Five cases of PVP storage disease with cutaneous involvement were studied. Two patients presented with cutaneous eruptions mimicking collagen vascular disease and chronic pigmented purpuric dermatosis. Two other cases were found incidentally: one was with a metastatic tumor and the other in a pemphigus lesion. The fifth case was seen in a blind skin biopsy spe… Show more

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Cited by 44 publications
(20 citation statements)
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“…However, PVP is also chemically stable and is not widely metabolized, leading to rapid accumulation, particularly in the reticuloendothelial system, blood vessels, liver, kidney, and spleen (19). Infiltration of PVP in bone marrow has been reported to be a complication of massive intravenous injection that was associated with severe irreversible anemia and destruction of bone (20).…”
Section: Figurementioning
confidence: 99%
“…However, PVP is also chemically stable and is not widely metabolized, leading to rapid accumulation, particularly in the reticuloendothelial system, blood vessels, liver, kidney, and spleen (19). Infiltration of PVP in bone marrow has been reported to be a complication of massive intravenous injection that was associated with severe irreversible anemia and destruction of bone (20).…”
Section: Figurementioning
confidence: 99%
“…It has also been inappropriately used for intravenous injections as a "blood tonic." 73 Larger polymers of PVP are phagocytized by macrophages and permanently stored in the reticular endothelial system, leading to the so-called PVP storage disease (Fig. 5).…”
Section: Systemic Drugsmentioning
confidence: 99%
“…This is because retention of polymers or nanosized materials in the body, even inert polymers like polyvinylpyrrolidone (PVP) [201][202][203], can cause health problems. The threshold for rapid renal excretion is about 5.5 nm in hydrodynamic diameter.…”
Section: The Materials Excipientability and Production Process Scale-umentioning
confidence: 99%