Cutaneous leishmaniasis in the Sudan

Abdalla, R. E.; Ali, Mohammad; Wasfi, A. I.; Hassan, A.M. El

doi:10.1016/0035-9203(73)90086-2

Cited by 29 publications

(9 citation statements)

References 18 publications

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“…The best drug of a bad bunch remains pentavalent antimony (pentostam), which is given daily for at least 14 days 13. Repetition of the course is needed in some patients 14…”

Section: Commentsmentioning

confidence: 99%

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Early Surgical Treatment of Cutaneous Leishmaniasis

Azab¹,

Kamal²,

Haggar³

et al. 1983

The Journal of Dermatologic Surgery and Oncology

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Cutaneous leishmaniasis, treated or untreated, is known to leave disfiguring scars. These scars are usually on exposed parts, for which plastic surgery may be required. The present work deals with the treatment of cutaneous leishmaniasis using surgical techniques from the onset. In 20 patients, 35 lesions were excised down to the deep fascia. To cover the resulting defect, subcuticular sutures were used in 7 small lesions. Dufourmental (LLL flap) and Limberg flaps were used in 23 lesions of moderate size. Free grafting was resorted to in five large lesions. Using these techniques, morbidity was reduced and cosmetic results were satisfactory.

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“…The best drug of a bad bunch remains pentavalent antimony (pentostam), which is given daily for at least 14 days 13. Repetition of the course is needed in some patients 14…”

Section: Commentsmentioning

confidence: 99%

“…Since antimonials are toxic to the heart, electro‐cardiogram is advised in every case,14 and the patient should be kept under strict observation for at least 1 hour after each injection 2. In addition, it is very difficult to establish a routine of daily injections in a tropical practice 15.…”

Section: Commentsmentioning

confidence: 99%

Early Surgical Treatment of Cutaneous Leishmaniasis

Azab¹,

Kamal²,

Haggar³

et al. 1983

The Journal of Dermatologic Surgery and Oncology

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“…CL in Sudan is similar to the disease in other endemic areas. There are 3 types: nodular or nodular‐ulcerative, ulcerative and diffuse infiltrative ( Abdalla et al . 1973 ).…”

Section: Clinical Presentation Of CLmentioning

confidence: 99%

“…The first reported autochthonous CL case was from the Nuba mountains ( Archibald 1911). CL patients mainly come from Darfur and the central belt of Sudan ( Abdalla et al . 1973 ; Abdalla & Sherif 1978).…”

Section: Introductionmentioning

confidence: 99%

Leishmaniasis in the Sudan: a literature review with emphasis on clinical aspects

Osman

Kager

Oskam

2000

Tropical Med Int Health

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SummaryThe literature on the leishmaniases in the Sudan is reviewed with an emphasis on clinical aspects and on literature related to the recent outbreaks in the south and east of the country.The numbers of cases of subclinical infection and post-kala azar dermal leishmaniasis in the recent outbreaks are remarkable. New diagnostic techniques have been introduced and evaluated, notably the direct agglutination test and polymerase chain reaction technology.The latter gives very promising results and further research into application of the technique is warranted.Treatment with pentavalent antimony is still satisfactory.The reservoir host has not been identified definitely.

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“…Antigen preparation is tedious and time consuming. 23,24 In addition M. mycetomatis has different structures in both the mycelial and grain phase, which have different antigenic determinants. 7 Due to the limitations and shortcomings of the currently available sero-diagnostic tools for mycetoma, this study set out to prepare a specific antigen of M. mycetomatis to differentiate between patients and healthy people and to develop a reliable and rapid method for accurate and timely diagnosis of eumycetoma.…”

Section: Introductionmentioning

confidence: 99%

Use of immunoblotting in testingMadurella mycetomatisspecific antigen

Elbadawi¹,

Mahgoub

Mahmoud³

et al. 2016

Trans R Soc Trop Med Hyg

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Background: Though serodiagnosis of actinomycetoma is established, that of eumycetoma due to Madurella mycetomatis is limited because of lack of pure antigen. Reliable rapid tests are needed to make an accurate timely diagnosis. The purpose of this study is to detect antigen parts of M. mycetomatis, which act specifically with M. mycetomatis antibodies.Methods: Cytoplasmic antigen was prepared from molecularly identified cultures of M. mycetomatis by sonication, ultracentrifugation, dried, weighed and appropriately reconstituted. M. mycetomatis cytoplasmic antigen were separated using 12% sodium dodecyl sulfate-polyacrylamide gel, and immunoblotting to detect the reactive ones.Immunoblotting was carried out in nitrocellulose strips containing different molecular size. Sera from patients and co-patients as control were used.Results: When stained with Coomassie brilliant blue R 250 seven molecular weights appeared but only three, 45, 60, 95 kDa reacted with M. mycetomatis patients few from control group, one from a malaria patient. No reactive band was observed with sera from actinomycetoma, Aspergillus flavus-associated aspergillosis, schistosomiasis, leishmaniasis, fungal sinusitis nor healthy controls.Conclusions: Specific fractions of M. mycetomatis antigen which were demonstrated by immunoblotting showed 75% sensitivity and 95% specificity. The true negative tests were 14 patients (32.5%). This also means that immunoblotting is reasonably reliable in diagnosis and follow-up of eumycetoma patients.

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Cutaneous leishmaniasis in the Sudan

Cited by 29 publications

References 18 publications

Early Surgical Treatment of Cutaneous Leishmaniasis

Early Surgical Treatment of Cutaneous Leishmaniasis

Leishmaniasis in the Sudan: a literature review with emphasis on clinical aspects

Use of immunoblotting in testingMadurella mycetomatisspecific antigen

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