Cutaneous Leishmaniasis in Venezuela Caused by Infection with a New Hybrid between Leishmania (Viannia) braziliensis and L. (V.) guyanensis

Delgado, Olinda; Cupolillo, Elisa; Bonfante-Garrido, Rafael; Silva, Sílvia; Belfort, Edgar; Grimaldi, Gabriel; Momen, Hooman

doi:10.1590/s0074-02761997000500002

Cited by 46 publications

(25 citation statements)

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“…In this regard, studies in particular endemic areas such as the Darien province near the Colombian border are necessary to confirm the taxonomy of Leishmania parasites that infect humans in these communities. Furthermore, the frequent reports of Leishmania Viannia hybrids causing CL in humans, 34 and more recently the implication of this subgenus in mucocutaneous clinical forms, 35 warrants the need to further study the taxonomy of Leishmania species circulating in the country and its epidemiologic implications.…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of American Tegumentary Leishmaniasis in Panama

Miranda¹,

Carrasco²,

Paz³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. American tegumentary leishmaniasis is an increasing public health problem in Panama. This study describes the clinical characteristics and the molecular epidemiology of leishmaniasis in Panama over a 5-year period (2004)(2005)(2006)(2007)(2008). Additionally, we applied a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) -based assay to identify Leishmania species in clinical isolates, skin scrapings, and sandflies specimens. Whereas 60.3% of cases were detected with conventional parasitologic techniques (smear or in vitro culture), the PCR detected 72% positive patients. Our clinical-epidemiologic data corroborate the high incidence of L. ( Viannia ) panamensis and provide evidence of peridomestic and/or domestic transmission. Mucosal involvement was observed in 4.2% of the patients. The overall natural infection rate with Leishmania in 103 pools of sandflies was 0.46%. Lutzomyia gomezi and Lutzomya panamensis were the prevalent species incriminated as vectors at the capture sites in central Panama. This study contributes to a better knowledge of the current epidemiology of tegumentary leishmaniasis in Panama.

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Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of American Tegumentary Leishmaniasis in Panama

Miranda¹,

Carrasco²,

Paz³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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“…A further taxonomic complication is presented by the occasional occurrence of natural interspecies hybrids (30)(31)(32)(33)(34)(35)(36)(37)(38), although these are quite rare. At the intraspecies or population level, sexual recombination might be frequent (39-44), but in general, a clonal mode of propagation is observed when looking at the greater picture (45).…”

Section: Evaluation Of Current Taxonomymentioning

confidence: 99%

Species Typing in Dermal Leishmaniasis

2015

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SUMMARY Leishmania is an infectious protozoan parasite related to African and American trypanosomes. All Leishmania species that are pathogenic to humans can cause dermal disease. When one is confronted with cutaneous leishmaniasis, identification of the causative species is relevant in both clinical and epidemiological studies, case management, and control. This review gives an overview of the currently existing and most used assays for species discrimination, with a critical appraisal of the limitations of each technique. The consensus taxonomy for the genus is outlined, including debatable species designations. Finally, a numerical literature analysis is presented that describes which methods are most used in various countries and regions in the world, and for which purposes.

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“…peruviana (26), L. braziliensis/L. guyanensis (10), L. braziliensis/L. panamensis (4), and L. lainsoni/L.…”

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Development of a Multilocus Microsatellite Typing Approach for Discriminating Strains of Leishmania ( Viannia ) Species

et al. 2009

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A multilocus microsatellite typing (MLMT) approach based on the analysis of 15 independent loci has been developed for the discrimination of strains belonging to different Viannia species. Thirteen microsatellite loci were isolated de novo from microsatellite-enriched libraries for both Leishmania braziliensis and L. guyanensis. Two previously identified markers, AC01 and AC16, were modified and added to our marker set. Cutaneous leishmaniasis (CL) is a serious but neglected public health problem that is endemic in 22 countries of Latin America, with Brazil and Colombia being among the six countries reporting 90% of the worldwide cases. Species of the subgenus Viannia cause the majority of cases of CL and mucocutaneous leishmaniasis (MCL) in South America and often overlap in their distribution (22). The subgenus is subdivided into species complexes representing Leishmania braziliensis, L. guyanensis, and L. naiffi (8). The L. guyanensis complex includes some named species, such as L. panamensis and L. shawi, which were found to be very similar to each other (7).

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Cutaneous Leishmaniasis in Venezuela Caused by Infection with a New Hybrid between Leishmania (Viannia) braziliensis and L. (V.) guyanensis

Cited by 46 publications

References 0 publications

Molecular Epidemiology of American Tegumentary Leishmaniasis in Panama

Molecular Epidemiology of American Tegumentary Leishmaniasis in Panama

Species Typing in Dermal Leishmaniasis

Development of a Multilocus Microsatellite Typing Approach for Discriminating Strains of Leishmania ( Viannia ) Species

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