Cutaneous leishmaniasis in Yemen

Khatri, Mishri Lal; Haider, Nasser

doi:10.1046/j.1365-4362.1999.00756.x

Cited by 12 publications

(13 citation statements)

References 9 publications

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“…This age-based incidence of CL is similar to previous studies on this subject in both Syria and Turkey. 7,9,[11][12][13][14][15] Interestingly, in contrast to Syrian patients, a higher female (58.5%) to male (41.5%) ratio was observed in Turkish patients. Similar reports of higher female incidence were observed in a recent study in Nizip, southern Turkey (61% female, 39% male), which is geographically close to Sanliurfa and is also endemic for CL.…”

Section: Discussionmentioning

confidence: 89%

“…Previous reports have shown that CL lesions are generally seen on uncovered parts of the body and less often on covered areas. 1,14,[20][21][22][23][24] This is not surprising since these are the areas that are readily accessible by the sandfly. A study in Turkey by Gurel and others 9 reported the location of CL lesions as 57.5% in the head and neck region, 32.2% in the upper extremities, 10.2% in the lower extremities, 0.8% in oral mucosa, 0.2% on the trunk, and no mucosal involvement.…”

Section: Discussionmentioning

confidence: 99%

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A Comparison of Demographic and Clinical Characteristics of Syrian and Turkish Patients with Cutaneous Leishmaniasis

Turan

Yeşilova

Sürücü

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Cutaneous leishmaniasis (CL) is a significant public health problem with increasing incidence, especially in extreme circumstances. In this study, we compared the sociodemographic and clinical characteristics of 685 Syrian CL patients afflicted by the Syrian conflict and 685 Turkish CL patients in 2012. Patient age, gender, duration of disease, lesion size, type, and localization were evaluated. The duration of CL disease in Syrian CL patients (4.5 ± 4.3 weeks) was shorter than that of Turkish CL patients (11.9 ± 9.7 weeks). The number of lesions was greater in Syrian patients (2.46 ± 2.43) than in Turkish patients (1.93 ± 1.47). Lesion sizes were comparable between both groups (Syrian, 11.2 ± 8.7 mm; Turkish, 10.7 ± 7.7 mm). In Syrian CL patients, nodular type lesions were the most common (325 patients, 49.1%), whereas, in Turkish CL patients, ulcer type lesions were the most common (352 patients, 51.5%). Our results indicate variations in the clinicoepidemiological features of CL between Turkish and Syrian patients within Sanliurfa province. This highlights the impact of social unrest and environmental conditions on the epidemiology of CL within this region. Approaches to prevention, control, and treatment of CL in these areas should take into consideration the emerging changes in clinicoepidemiological parameters of the disease.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

A Comparison of Demographic and Clinical Characteristics of Syrian and Turkish Patients with Cutaneous Leishmaniasis

Turan

Yeşilova

Sürücü

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Leishmaniasis was endemic in Yemen [2]. It has been recognized as a public health problem predominated by infection with the highest burden of Leishmaniasis, but has not been fully documented [18]. CL is endemic and most of the cases are registered in Lahg, Abun, Hagga and Sa’adah Taiz Governorates [3].…”

Section: Resultsmentioning

confidence: 99%

Parasitological and biochemical studies on cutaneous leishmaniasis in Shara’b District, Taiz, Yemen

Asmaa

AL-Shamerii

Al-Tag

et al. 2017

Ann Clin Microbiol Antimicrob

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BackgroundThe leishmaniasis is a group of diseases caused by intracellular haemoflagellate protozoan parasites of the genus Leishmania. Leishmaniasis has diverse clinical manifestations; cutaneous leishmaniasis (CL) is the most common form of leishmaniasis which is responsible for 60% of disability-adjusted life years. CL is endemic in Yemen. In Shara’b there is no reference study available to identify the prevalence of endemic diseases and no investigation has been conducted for diagnosing the diseases.MethodsThis study was conducted in villages for CL which collected randomly. The study aimed at investigating the epidemiological factors of CL in Shara’b by using questioner. Symptoms of lesions in patients suffering from CL, confirmed by laboratory tests, gave a new evidence of biochemical diagnosis in 525 villagers aged between 1 and 60 years old. Venous bloods were collected from 99 patients as well as from 51 control after an overnight fast.ResultsThe percentage prevalence of CL was found 18.8%. The prevalence rate of infection among males (19.3%) was higher than females (18.40%). Younger age group (1–15) had a higher prevalence rate (20.3%) than the other age groups. Furthermore, the population with no formal education had the higher rate of infection (61% of the total). A significant increase of serum malondialdehyde (P < 0.001) in CL patients was obtained. The highest level of MDA may be due to over production of ROS and RNS results in oxidative stress and the acceleration of lipid peroxidation in CL patients.ConclusionsThere were high prevalence rates of CL in Shara’b. The patient who had CL has been found with many changes in some biochemical levels. This study provides a clear indication on the role of MDA as an early biochemical marker of peroxidation damage occurring during CL. Increased uric acid, and catalase activity was provided of free radical.

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“…Systemic Pentostam is the drug of choice. In view of the cases of dissemination occurring despite Pentostam therapy, the addition of another systemic drug, such as rifampicin, 20,21 can be considered where Pentostam proves to be inadequate. Topical drugs such as clotrimazole may also play a role in therapy 22 …”

Section: Discussionmentioning

confidence: 99%

Dissemination in cutaneous leishmaniasis due to Leishmania major in different ethnic groups in Saudi Arabia

et al. 2000

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Cutaneous leishmaniasis in Yemen

Cited by 12 publications

References 9 publications

A Comparison of Demographic and Clinical Characteristics of Syrian and Turkish Patients with Cutaneous Leishmaniasis

A Comparison of Demographic and Clinical Characteristics of Syrian and Turkish Patients with Cutaneous Leishmaniasis

Parasitological and biochemical studies on cutaneous leishmaniasis in Shara’b District, Taiz, Yemen

Dissemination in cutaneous leishmaniasis due to Leishmania major in different ethnic groups in Saudi Arabia

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