Cutaneous leishmaniasis treatment

Minodier, Philippe; Parola, Philippe

doi:10.1016/j.tmaid.2006.09.004

Cited by 208 publications

(160 citation statements)

References 91 publications

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“…The clinical features of ACL consist of dry or late ulcerative lesion (Firooz et al 2004). The first line-therapy for ACL, according to WHO recommendation, is the pentavalent antimony compounds such as meglumine antimoniate (Glucantime) (Minodier and Parola 2007). Other treatments for cutaneous leishmaniasis (CL) are antifungal agents, azithromycin, paromomycin ointment, and physical treatment like cryotherapy (cryosurgery) (Prata et al 2003;Dogra et al 1990;Al majalio and Routh 1997;Esfandiarpour and Alavi 1997).…”

Section: Introductionmentioning

confidence: 99%

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

et al. 2014

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Zinc sulfate (ZS) has been used for the treatment of acute cutaneous leishmaniasis (CL) in both forms of in vivo and in vitro recently. The aim of the present study was to compare the efficacy of intralesional injection of ZS 2 % solution with intralesional glucantime in the treatment of acute CL. In this double-blind randomized clinical trial, 80 cases with acute old world dry type CL were enrolled in the study. The treatment protocol in the first group consisted of intralesional injection of ZS 2 % vials once a week for 10 weeks or sooner in case of complete resolution of the lesions. In the second group, intralesional glucantime once a week for 10 weeks or sooner in case of complete resolution of the lesions were used. In both groups cryotherapy was performed once every other week for 10 weeks. In ZS versus second group, partial and complete clinical response was observed with fewer injections although this difference was not statistically significant. In addition, we found that the trend of treatment in second group was faster but again it was not significant [partial treatment: hazard ratio (HR) 1.4, 95 % CI 0.7-2.9; complete treatment: HR 1.3, 95 % CI 0.6-2.8].The results of this study showed that the intralesional injection of ZS 2 % solution was as effective as glucantime on the healing of the acute old world dry type CL.

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Section: Introductionmentioning

confidence: 99%

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

et al. 2014

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“…Pentavalent antimonials, örneğin meglumine antimoniate (glukantim), KL'nin tedavisinde en sık tercih edilen ajandır. KL yapan leishmania türüne ve hastalığın klinik bulgularına göre sistemik veya intralezyonel metod tercih edilir (11,13 …”

Section: Discussionunclassified

A cutaneous leishmania case left a deep scar on the face and delayed at diagnosis

Alan¹,

Başsorgun²

2015

Turk J Bioch

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Kutanöz leishmaniasis (KL), enfekte tatarcıkların deriden kan emerken bulaştırdıkları leishmania türlerinin memeli konaklarda oluşturdukları bir hastalık grubudur. Kutanöz morfolojideki çeşitlilikten dolayı KL sık görülen pek çok dermatozu taklit edebilmekte ve endemik olmayan bölgelerde tanı ve tedavide yanılgılara yol açabilmektedir. Gereksiz cerrahi müdaheleler hastalığın alevlenmesine neden olmaktadır. KL lezyonları sıklıkla kendiliğinden gerileme eğiliminde olsa da tedavisiz bırakılan olgular bulaş açısından kaynak ve risk oluşturduğundan ve kozmetik öneme sahip bölgelerde kötü görünümde deriden çökük skar oluşumuna yol açabileceğinden dolayı erken tanı ve tedavi büyük önem taşımaktadır. Bunun yanı sıra skar zemininde nadir de olsa bazal hücreli karsinom (BHK) ve skuamoz hücreli karsinom (SHK) gelişme riskinin olması da erken tanı ve tedavinin önemini arttırmaktadır.Cutaneous leishmaniasis (CL) is a disease group created by leishmania species which are transmitted by infected sandflies while sucking blood from the skin in mammal hosts. Due to the variety in cutaneous morphology, CL can imitate several frequent dermatosis, and cause a fallacy in diagnosis and treatment in non-endemic regions. Unnecessary surgical interventions cause the disease to inflame. Cutaneous leishmania lesions deprived of the treatment pose a risk and source for infection. Moreover, untreated CL lesions can cause cutaneously pitted scar formation. Due to these reasons, early diagnosis and treatment have a great importance. Moreover, the risk of BCC and SCC development even rarely on scare basis increases the importance of early diagnosis and treatment.Anahtar Kelimeler: Demir eksikliği anemisi, tiroid.

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“…El ataque a las mucosas está relacionado, 22,15,23 probablemente, a infección por la L. (V.) braziliensis , lo que refuerza la posibilidad de que esta especie sea la principal responsable por la LTA en Alagoas. Esa forma está asociada a la persistencia del parásito en los tejidos con migración posterior por la corriente sanguínea como 24 también pela vía linfática .…”

Section: Discussionunclassified

Indicadores epidemiológicos da leishmaniose tegumentar americana, no período de 1999 a 2008, no Estado de Alagoas, Brasil

2010

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Cutaneous leishmaniasis treatment

Cited by 208 publications

References 91 publications

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

A cutaneous leishmania case left a deep scar on the face and delayed at diagnosis

Indicadores epidemiológicos da leishmaniose tegumentar americana, no período de 1999 a 2008, no Estado de Alagoas, Brasil

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