2023
DOI: 10.1016/j.abd.2022.09.005
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Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects

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Cited by 20 publications
(26 citation statements)
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“…Cutaneous inflammation is quite common in patients with SLE. 41 The activation of the innate and adaptive immune systems promotes skin tissue inflammation, thus resulting in cytotoxic damage. Accumulated damage resulting from chronic inflammation leads to the inability of keratinocytes and fibroblasts to produce crucial cellular components compared to their younger counterparts.…”
Section: Discussionmentioning
confidence: 99%
“…Cutaneous inflammation is quite common in patients with SLE. 41 The activation of the innate and adaptive immune systems promotes skin tissue inflammation, thus resulting in cytotoxic damage. Accumulated damage resulting from chronic inflammation leads to the inability of keratinocytes and fibroblasts to produce crucial cellular components compared to their younger counterparts.…”
Section: Discussionmentioning
confidence: 99%
“…Etiopathogenesis of TLE has not been yet fully elucidated but is believed to involve a complex interplay between genetic, environmental, and immunological factors [19,21,22]. Ultraviolet (UV) radiation is a major triggering factor in most, but not all TLE patients [15,23].…”
Section: Etiopathogenesismentioning
confidence: 99%
“…Similar to other types of cutaneous lupus erythematosus, plasmacytoid dendritic cells (pDCs) recruitment is believed to be a major factor in the pathogenesis, with the resultant production of Interferon type I (IFN-I). The latter subsequently leads to the activation of T-lymphocytes and the induction of chemokines and cytokines [22,33].…”
Section: Etiopathogenesismentioning
confidence: 99%
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