Cutaneous lymphocyte-associated antigen (CLA) T cells up-regulate P-selectin ligand expression upon their activation

Ni, Zhenya; Walcheck, Bruce

doi:10.1016/j.clim.2009.07.010

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…This fact, together with the finding that T cell inflammatory reactions are important regulators of lymphedema, suggests that the expression of skin homing receptors may also play an important role in the development of lymphedema. This hypothesis is supported by the finding that the expression of CLA ligand E-selectin ( 74 ) as well as other leukocyte adhesion molecules (ICAM1, VCAM1) is significantly increased in lymphedematous skin ( 60 ). Similarly, we have found that the expression of ligands for CCR4 [chemokine c-c motif ligand 17 (CCL17)] and CCR10 (CCL27) ( 75 ) is markedly increased in keratinocytes of lymphedematous skin.…”

Section: Lymphedema Results In a Mixed T Helper Cell Differentiation mentioning

confidence: 84%

Regulation of Immune Function by the Lymphatic System in Lymphedema

et al. 2019

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The lymphatic vasculature has traditionally been thought to play a passive role in the regulation of immune responses by transporting antigen presenting cells and soluble antigens to regional lymph nodes. However, more recent studies have shown that lymphatic endothelial cells regulate immune responses more directly by modulating entry of immune cells into lymphatic capillaries, presenting antigens on major histocompatibility complex proteins, and modulating antigen presenting cells. Secondary lymphedema is a disease that develops when the lymphatic system is injured during surgical treatment of cancers or is damaged by infections. We have used mouse models of lymphedema in order to understand the effects of chronic lymphatic injury on immune responses and have shown that lymphedema results in a mixed T helper cell and T regulatory cell (Treg) inflammatory response. Prolonged T helper 2 biased immune responses in lymphedema regulate the pathology of this disease by promoting tissue fibrosis, inhibiting formation of collateral lymphatics, decreasing lymphatic vessel pumping capacity, and increasing lymphatic leakiness. Treg infiltration following lymphatic injury results from proliferation of natural Tregs and suppresses innate and adaptive immune responses. These studies have broad clinical relevance since understanding how lymphatic injury in lymphedema can modulate immune responses may provide a template with which we can study more subtle forms of lymphatic injury that may occur in physiologic conditions such as aging, obesity, metabolic tumors, and in the tumor microenvironment.

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Section: Lymphedema Results In a Mixed T Helper Cell Differentiation mentioning

confidence: 84%

Regulation of Immune Function by the Lymphatic System in Lymphedema

et al. 2019

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“…Furthermore, PSGL-1 can be modified via a carbohydrate epitope through fucosyltransferase VII activity into the cutaneous lymphocyte-associated antigen (CLA) that regulates tissue-specific homing of memory T cells [106]. Resident T cells in the lung and skin express high levels of PSGL-1, but only those in the skin are CLA + [105–108]. In contrast, effector memory cells can engage P-selectin to migrate into lymph nodes undergoing a response [26].…”

Section: Functions Of Psgl-1 In T Cellsmentioning

confidence: 99%

PSGL-1: A New Player in the Immune Checkpoint Landscape

Tinoco

Otero

Takahashi

et al. 2017

Trends in Immunology

115

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P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. However, recent findings indicate that PSGL-1 can also negatively regulate T cell function. As T cell differentiation is finely tuned by multiple positive and negative regulatory signals that appropriately scale the magnitude of the immune response, PSGL-1 has emerged as an important checkpoint during this process. Here we summarize what is known regarding PSGL-1 structure and function and highlight how it may act as an immune checkpoint inhibitor in T cells.

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“…A decrease in the level of lymphocytes in group C animals may be due to their release from the circulation for the implementation of regulatory protective functions directly in the endothelial tissues, as well as, possibly, in the underlying connective tissue and peripheral immune organs. In particular, it is known that up to 15% of circulating blood cells are CLA-positive T-lymphocytes associated with the cutaneous lymphocyte antigen CLA, which is considered a receptor that controls the affinity of T-lymphocytes for the skin ( Ni and Walcheck, 2009 , De Jesús-Gil et al, 2018 ). It can be assumed that the investigated biomolecules, on the one hand, send CLA-positive T-lymphocytes from the bloodstream to the inflammation focus, and on the other hand, increase the functional activity of lymphocytes and other leukocytes remaining in the blood.…”

Section: Discussionmentioning

confidence: 99%

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

Basov

Fedulova

Vasilevskaya

et al. 2021

Saudi Journal of Biological Sciences

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Influence of a new protein-peptide complex on promoting skin wound healing in male BALB/c mice was studied. Protein-peptide complex, extracted from Sus scrofa immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin Sus scrofa (C3VVV8_PIG, m / z 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals.

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Cutaneous lymphocyte-associated antigen (CLA) T cells up-regulate P-selectin ligand expression upon their activation

Cited by 11 publications

References 48 publications

Regulation of Immune Function by the Lymphatic System in Lymphedema

Regulation of Immune Function by the Lymphatic System in Lymphedema

PSGL-1: A New Player in the Immune Checkpoint Landscape

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

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