Cutaneous malignant melanoma in Scotland

Rm, MacKie; Hunter, John

doi:10.1038/bjc.1982.167

Cited by 23 publications

(8 citation statements)

References 20 publications

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“…Most of the previous studies were high-volume studies; hence, they reported more cases at each site. In spite of the relatively small number of cases reviewed in the present study, when categorized into different sites, this study is in agreement with the fact that the most frequent site for malignant melanomas in males is the upper back, and in females it is the lower leg and ankle, even across populations from different geographic areas (20,25,26,27,28).…”

Section: Discussionsupporting

confidence: 69%

Malignant melanomas treated by plastic surgeons in Hamilton, Ontario: A retrospective study of 80 patients with clinical and histological correlation

1999

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Section: Discussionsupporting

confidence: 69%

Malignant melanomas treated by plastic surgeons in Hamilton, Ontario: A retrospective study of 80 patients with clinical and histological correlation

1999

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“…In the British Isles a female to male ratio for melanoma of approximately two-to-one has been reported (Lee & Storer, 1980;MacKie & Hunter, 1982) compared with only a small female excess in most other parts of the world. It may be that this marked sex differential is obliterated in other countries by a larger number of predominantly 'solar' cases in those areas.…”

Section: Thicknessmentioning

confidence: 99%

“…Shaw et al, 1980;Balch et al, 1978;MacKie & Hunter, 1982;Eastwood & Baker, 1983. This could be due to more aggressive disease but is more likely related to diagnostic delay associated with decreased public and professional awareness of the disease.…”

Section: Thicknessmentioning

confidence: 99%

“…The disease is found in a younger age group than most other forms of cancer. Different forms of melanoma may have different patterns of incidence, growth and prognosis.Apart from Scotland (MacKie & Hunter, 1982) it has been unusual to use the population of an entire country as the basis for a study of melanoma and correlate histopathological parameters with age, sex and site. Northern Ireland is a relatively closed geographical entity with sufficient numbers of cases for analysis.…”

mentioning

confidence: 99%

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The incidence and pathogenesis of invasive cutaneous malignant melanoma in Northern Ireland

Gordon¹,

Lowry²

1986

Br J Cancer

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Summary Three hundred and four suspected cases of malignant melanoma diagnosed in Northern Ireland over a 5 year period have been reviewed. Two hundred and forty fulfilled the diagnostic criteria of invasive cutaneous malignant melanoma (CMM) and were accepted as suitable for analysis an incidence of 3.12. The female to male ratio for CMM in this study is 3:1. This excess of female lesions occurs at all major anatomical sites and for all tumour types. There are many thick melanomas in the province, and 67% of cases were greater than 1.7mm thick. Each tumour type has a distinctive age curve. The implications of these findings are discussed. The evidence suggests that intrinsic factors are as important as extrinsic factors.Malignant melanoma is a potentially lethal form of skin cancer. Its incidence and mortality is increasing in most countries studied. The disease is found in a younger age group than most other forms of cancer. Different forms of melanoma may have different patterns of incidence, growth and prognosis.Apart from Scotland (MacKie & Hunter, 1982) it has been unusual to use the population of an entire country as the basis for a study of melanoma and correlate histopathological parameters with age, sex and site. Northern Ireland is a relatively closed geographical entity with sufficient numbers of cases for analysis. Moreover its limited size allows accessibility to virtually all patients. A detailed' histopathological examination of all cases of melanoma referred to the three pathology centres over a 5-year period was therefore undertaken.The population of Northern Ireland was 1,538,800 at the time of this study. It is situated between 54°N and 56°N latitude. There is a maritime climate and the annual solar radiation incident on a horizontal surface is 1,000kWh per square meter (Cruikshank & Wilcock, 1982 cases were accepted for the study. There are only three pathology centres in Northern Ireland and all biopsy specimens are submitted to these centres. Through the kind co-operation of the consultant pathologists, the histopathological records of the three centres were completely reviewed for the 5-year period between 1974-1978. The only possible cases of melanoma that might not be included in this survey would presumably be those cases not submitted for biopsy. At a joint melanoma group meeting with general surgeons, plastic surgeons, pathologists, dermatologists and other clinicians in the province, it was considered that very few cases of melanoma would escape histopathological confirmation in Northern Ireland.Eye lesions, metastases from primaries diagnosed previously, and second excisions were all excluded. Cases of multiple primary melanoma were only considered if the first primary occurred during the period of study.Three hundred and four cases were thus available for study. Of these, 15 cases of lymph node melanoma had no identifiable primary site and were excluded because no cutaneous melanoma has been found. The remaining 289 cases were histopathologically examined. Eight cases of anal, vag...

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“…In patients with vertical growth-phase primary tumours, Breslow thickness at presentation is the most important single prognostic indicator in CMM (MacKie et al, 1985;Masback et al, 2001), with 5 years survival values ranging from 93% for tumours < 1.5 mm thick, compared with 67% for 1.5 -3.49 mm tumours, to 37% for tumours > 3.5 mm thick (MacKie et al, 1992). Therefore, investigation of ICAM-1 genotypes in terms of tumour Breslow thickness was of particular interest.…”

Section: Discussionmentioning

confidence: 99%

ICAM‐1 polymorphisms and development of cutaneous malignant melanoma

Howell¹,

Rose-Zerilli²,

Theaker³

et al. 2005

Int J Immunogenetics

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Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). ICAM-1 expression is associated with increasing Breslow thickness of vertical growth-phase tumours and, in patients with stage 1 disease, may be associated with disease free and patient survival. In this study we have investigated whether two single nucleotide polymorphisms (SNPs) in the ICAM-1 gene encoding amino acid substitutions in codons 241 and 469 of the expressed ICAM-1 molecule are associated with susceptibility to and markers of prognosis (including tumour Breslow thickness) in CMM. A total of 164 CMM patients and 264 cancer-free controls were genotyped for these SNPs by the 5' nuclease assay for allelic discrimination (TaqMan). No genotypes showed any significant associations with CMM susceptibility, although there was a non-significant increase in frequency of the ICAM-1 469 AA genotype among CMM patients vs. controls (38.4% vs. 29.9%; P = 0.11). However, the ICAM-1 241 GG genotype was significantly decreased in frequency among patients with primary invasive tumours of greater Breslow thickness (72.5% vs. 91.2%; P = 0.013; OR = 0.25 (0.072-0.85)). These results provide no evidence for a role for the ICAM-1 codon 241 and 469 SNPs in determining susceptibility to CMM, but provide preliminary evidence that the role of ICAM-1 polymorphism in modulating tumour growth in CMM requires further investigation in a larger study group.

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Cutaneous malignant melanoma in Scotland

Cited by 23 publications

References 20 publications

Malignant melanomas treated by plastic surgeons in Hamilton, Ontario: A retrospective study of 80 patients with clinical and histological correlation

Malignant melanomas treated by plastic surgeons in Hamilton, Ontario: A retrospective study of 80 patients with clinical and histological correlation

The incidence and pathogenesis of invasive cutaneous malignant melanoma in Northern Ireland

ICAM‐1 polymorphisms and development of cutaneous malignant melanoma

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