Cutaneous manifestations in patients with type 2 diabetes mellitus and normal controls

Roslind, Sangeetha; Muhammed, Kunnummal; Kumar, K. G. Sajeeth

doi:10.25259/jsstd_47_2019

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…[14] A high fasting blood glucose noted in 61% of our patients was comparable to many previous studies. [2,7,12,[15][16][17] e significant lipid abnormality noted in our patients was a low HDL, which was concurrent with other studies. [7,9] Low levels of HDL irrespective of the serum levels of total cholesterol or low-density lipoprotein are considered as the strongest predictor of cardiovascular morbidity.…”

Section: Discussionsupporting

confidence: 89%

“…Increased waist circumference was noted in a majority (77%) of cases, but there was no significant difference from control group, which was contradictory to the previous studies. [10,12] However, on calculating BMI, 42% of the cases were overweight and 12% were obese which were significant and in accordance with other studies. [8,13] Plausible mechanisms for higher prevalence of acrochordons in obesity are hyperinsulinemia and increased leptin levels.…”

Section: Discussionsupporting

confidence: 89%

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Acrochordon as a marker of metabolic syndrome – A cross-sectional study from South India

Sherin

Khader

Binitha

et al. 2022

JSSTD

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Objectives: To determine the association of acrochordons with metabolic syndrome and its components. Materials and Methods: A cross-sectional study was conducted in 100 patients with acrochordon and 100 age- and gender-matched controls who attended the dermatology outpatient department of a tertiary care center in South India from January 2017 to December 2017. A detailed dermatological examination was carried out in cases with respect to distribution, number, color, and morphology of acrochordons. Blood pressure (BP), pulse rate, waist circumference, height, weight, and body mass index were recorded in all cases and controls. Fasting lipid profile, fasting blood sugar, liver function test, and renal function test were done in all study participants. A diagnosis of metabolic syndrome was made based on the International Diabetes Federation metabolic syndrome worldwide definition specified for the Asian population. Statistical analysis was done using Pearson’s Chi-square test. Results: There were 52 females and 48 males in each group. About 80% of patients belonged to the age group of 20–50 years. A significantly higher number of cases had metabolic syndrome (P < 0.001). Acrochordons showed a significant association with the components of metabolic syndrome such as high BP (P < 0.001), high fasting plasma glucose levels (P < 0.001), and low levels of high-density lipoprotein cholesterol (P = 0.04). Comparison of cases showed that patients with acrochordons limited to axilla were less likely to have metabolic syndrome in comparison to those who had acrochordons on other body sites with or without involvement of axilla (P = 0.008). Patients who manifested only sessile lesions were less likely to have metabolic syndrome when compared to those who manifested pedunculated/filiform/pedunculated and filiform lesions (P < 0.001). Limitations: A cross-sectional study design and study carried out in a tertiary referral center were the limitations. Conclusion: A significant association was noted between acrochordons and metabolic syndrome.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Acrochordon as a marker of metabolic syndrome – A cross-sectional study from South India

Sherin

Khader

Binitha

et al. 2022

JSSTD

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“…We found that out of 108 patients, males were 60 and females were 48. Roslind et al 10 studied the cutaneous manifestations in patients with type 2 diabetes mellitus (DM) in comparison to normal subjects and to document the association between cutaneous manifestations and complications of DM. In this 1-year comparative cross-sectional study, 100 patients receiving treatment at the diabetic clinic of a tertiary center were evaluated for cutaneous manifestations and complications due to diabetes.…”

Section: Discussionmentioning

confidence: 99%

evaluation of skin manifestations in type 2 diabetes mellitus

Matwa¹,

Kala²,

Kumar

2022

ijhs

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Background: Diabetes mellitus (DM) is a common endocrinopathy and assumes significance for its ability to adversely affect the various internal organs. The present study was conducted to assess skin manifestations in type II diabetes mellitus patients. Materials & Methods: 108 patients of type II diabetes mellitus of both genders were enrolled. Blood sugar level was determined on venous samples. Urine microscopy, renal function tests, fasting lipid profile, electrocardiogram, 24 h urine protein estimation, and fundoscopy were performed wherever indicated. Results: Out of 108 patients, males were 60 and females were 48. Cutaneous manifestations in type II DM patients was bacterial infection in 12, fungal infection in 10, viral infection in 8, diabetic bullae in 6, dermopathy in 3, tropic ulcer in 2, acanthosis nigran in 7, wet gangrene in 5, peripheral neuropathy in 3 and hirsutism in 2 cases. The difference was significant (P< 0.05). Conclusion: Most common cutaneous manifestation in type II diabetes mellitus patients was bacterial infection, fungal infection, viral infection, diabetic bullae, dermopathy, tropic ulcer and acanthosis nigran.

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“…However, as the disease progresses, it can cause damage to the vascular, neurologic, and immune systems, which can lead to skin problems. 4,8,13 Skin symptoms may appear before a DM diagnosis and be due to the disease, or they can appear during the course of diabetes as a result of diabetes complications or antidiabetic treatment side effects. 10,13 The most common skin problems in 100 patients with T2DM diabetes aged 34 to 76 years, according to one study in 2020, were fungal infections (55%).…”

Section: Pathophysiology Of Dm On Skinmentioning

confidence: 99%

“…4,8,13 Skin symptoms may appear before a DM diagnosis and be due to the disease, or they can appear during the course of diabetes as a result of diabetes complications or antidiabetic treatment side effects. 10,13 The most common skin problems in 100 patients with T2DM diabetes aged 34 to 76 years, according to one study in 2020, were fungal infections (55%). 13 The following is a list of the most common skin problems that patients with DM face, regardless of whether they have T1DM or T2DM.…”

Section: Pathophysiology Of Dm On Skinmentioning

confidence: 99%

Potential skin problems of diabetes mellitus patients: a review

2022

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Diabetes mellitus (DM) is one of the common metabolic disorders, and a major part of chronic diseases, the prevalence of which tends to increase due to multifactor. Blood vessels, kidneys, lungs, and skin are among the organs that are affected. The first problem that arises, or commonly exists among one-third of diabetics, are problems with their skin, although skin lesions may develop along with the progress of the disease, or can occur during the later phase of DM. The prevalence and symptoms of skin problems in type 1 DM (T1DM) and type 2 DM (T2DM) are often unclear, and at the beginning of the course of the diseases they often go undiagnosed. Several theories regarding the pathophysiology of DM can be used as a logical reference for the early identification and diagnosis of skin problems, aimed at preventing the worsened condition. The use of skin autofluorescence (SAF) and AGEs reader in several cases of skin problems, can also be an important marker as an adjunct to predict the possibility and progressiveness of DM. Skin problems linked to patients with DM can be categorized as strongly related to diabetes, non-specific and related to DM, skin infection in DM, and skin problems due to diabetic medication. With the current COVID-19 pandemic, there are additional demands for more critical investigation of skin problems in patients with DM. The skin problems that occur in DM may need to be examined from the early stage and it is necessary to inhibit the progression of skin problems, as well as to consider the need for multidisciplinary DM therapy.

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Cutaneous manifestations in patients with type 2 diabetes mellitus and normal controls

Cited by 6 publications

References 14 publications

Acrochordon as a marker of metabolic syndrome – A cross-sectional study from South India

Acrochordon as a marker of metabolic syndrome – A cross-sectional study from South India

evaluation of skin manifestations in type 2 diabetes mellitus

Potential skin problems of diabetes mellitus patients: a review

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