Cutaneous Manifestations of Chronic Kidney Disease, Dialysis and Post-Renal Transplant

Goel, Vivek; Sil, Abheek; Das, Anupam

doi:10.4103/ijd.ijd_502_20

Cited by 17 publications

(1 citation statement)

References 41 publications

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“…The toxins accumulate in the body, which further causes the disorder of water, electrolyte, and acid-base balance in the body; it harms the patients and makes their bodies uncomfortable [ 5 ]. Hemodialysis can purify patients' blood and replenish the body with solutes, but the therapeutic effect of hemodialysis alone for uremia patients cannot reach an ideal state [ 6 ]. Therefore, this study was based on hemodialysis and effectively combined with MDT multimode intervention.…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Investigation on the Effect of Hemodialysis Combined with MDT Multimode Intervention on Renal Fibrosis Degree and Renal Function Improvement in Uremia Patients

Fan

Zhang

et al. 2022

Contrast Media & Molecular Imaging

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The effect of hemodialysis combined with MDT intervention on the degree of renal fibrosis and renal function in uremia patients was studied. 118 patients with uremia admitted to the hospital were selected as the research object, and they were divided into two groups according to the random number table method, 59 cases in the control group and 59 cases in the experimental group. The control group was treated with hemodialysis, and the experimental group was treated with MDT multimode intervention on the basis of hemodialysis. The differences in renal fibrosis, renal function, and satisfaction after treatment were compared before treatment and at 1, 3, and 6 months after treatment. The experimental results showed that hemodialysis combined with MDT multimode intervention in uremia patients could reduce renal fibrosis and improve renal function and improve clinical satisfaction evaluation.

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Section: Related Workmentioning

confidence: 99%

[Retracted] Investigation on the Effect of Hemodialysis Combined with MDT Multimode Intervention on Renal Fibrosis Degree and Renal Function Improvement in Uremia Patients

Fan

Zhang

et al. 2022

Contrast Media & Molecular Imaging

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Epigenome-wide association study of diabetic chronic kidney disease progression in the Korean population: the KNOW-CKD study

Sung

Lee

et al. 2023

Sci Rep

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Since the etiology of diabetic chronic kidney disease (CKD) is multifactorial, studies on DNA methylation for kidney function deterioration have rarely been performed despite the need for an epigenetic approach. Therefore, this study aimed to identify epigenetic markers associated with CKD progression based on the decline in the estimated glomerular filtration rate in diabetic CKD in Korea. An epigenome-wide association study was performed using whole blood samples from 180 CKD recruited from the KNOW-CKD cohort. Pyrosequencing was also performed on 133 CKD participants as an external replication analysis. Functional analyses, including the analysis of disease-gene networks, reactome pathways, and protein–protein interaction networks, were conducted to identify the biological mechanisms of CpG sites. A phenome-wide association study was performed to determine the associations between CpG sites and other phenotypes. Two epigenetic markers, cg10297223 on AGTR1 and cg02990553 on KRT28 indicated a potential association with diabetic CKD progression. Based on the functional analyses, other phenotypes (blood pressure and cardiac arrhythmia for AGTR1) and biological pathways (keratinization and cornified envelope for KRT28) related to CKD were also identified. This study suggests a potential association between the cg10297223 and cg02990553 and the progression of diabetic CKD in Koreans. Nevertheless, further validation is needed through additional studies.

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The Spectrum of Nail Disorders in Patients With End-Stage Renal Disease Undergoing Conservative Treatment: A Case-Control Study

Shigidi

2024

International Journal of Dermatology and Venereology

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Objective: Various nail disorders have been reported in patients with chronic kidney disease (CKD). However, few studies have investigated nail disorders in patients with advanced CKD. This study focused on nail disorders seen in patients with end-stage renal disease (ESRD) undergoing conservative treatment. Methods: A case–control study was conducted at Baraha Medical City in Khartoum State, Sudan. Patients with ESRD who were on conservative treatment and presented for follow-up between March and September 2021 were enrolled. Patients’ demographic features, nail findings on clinical examination, and laboratory results were recorded. The obtained data were compared with those of age- and sex-matched healthy individuals from the general population. The statistical analysis was performed using SPSS software. Results: Seventy-eight patients with ESRD were studied. Their mean age was 54.6 ± 17.6 years, and 45 (57.7%) were men. These patients were compared with 129 controls. Nail disorders were seen in 83.3% and 66.6% of patients and controls, respectively (P = 0.009). Patients with ESRD were found to be at increased relative risk of developing a wide spectrum of nail disorders. An absent lunula, half-and-half nails, nail dystrophy, Terry’s nails, onychomycosis, and koilonychia were the most common disorders and were seen in 56.4%, 16.7%, 12.8%, 11.5%, 7.7%, and 6.4% of patients, respectively. These disorders had a statistically significant correlation with ESRD (all P < 0.05). Conclusion: The current study demonstrated a wide spectrum of nail disorders in patients with ESRD undergoing conservative treatment. Further studies are essential to understand their pathogenesis.

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Cutaneous Manifestations of Chronic Kidney Disease, Dialysis and Post-Renal Transplant

Cited by 17 publications

References 41 publications

[Retracted] Investigation on the Effect of Hemodialysis Combined with MDT Multimode Intervention on Renal Fibrosis Degree and Renal Function Improvement in Uremia Patients

[Retracted] Investigation on the Effect of Hemodialysis Combined with MDT Multimode Intervention on Renal Fibrosis Degree and Renal Function Improvement in Uremia Patients

Epigenome-wide association study of diabetic chronic kidney disease progression in the Korean population: the KNOW-CKD study

The Spectrum of Nail Disorders in Patients With End-Stage Renal Disease Undergoing Conservative Treatment: A Case-Control Study

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