Cutaneous manifestations of chronic kidney disease

Kurban, Mazen; Boueiz, Adel; Kibbi, Abdul‐Ghani

doi:10.1016/j.clindermatol.2007.10.017

Cited by 62 publications

(86 citation statements)

References 78 publications

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“…In ESRD, porphyria cutanea tarda and pseudoporphyria may be seen (4,62). Both are caused by the accumulation of photosensitive molecules in the skin that, on ultraviolet light exposure, leads to skin fragility and vesiculation on sun-exposed areas (4).…”

Section: Bullous Diseasesmentioning

confidence: 99%

“…Treatment of pseudoporphyria involves stopping/ avoiding any of the medications known to induce the disease (for example, diuretics, antibiotics, and antifungals) as well as sun avoidance and sun protection. N-Acetylcysteine, a metabolic precursor of glutathione that increases antioxidant activity and clearing of free radicals, is an effective treatment for pseudoporphyria (62).…”

Section: Bullous Diseasesmentioning

confidence: 99%

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Cutaneous Manifestations of ESRD

Galperin

Cronin

Leslie

2014

Clinical Journal of the American Society of Nephrology

193

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SummaryA broad range of skin diseases occurs in patients with ESRD: from the benign and asymptomatic to the physically disabling and life-threatening. Many of them negatively impact on quality of life. Their early recognition and treatment are essential in reducing morbidity and mortality. The cutaneous manifestations can be divided into two main categories: nonspecific and specific. The nonspecific manifestations are commonly seen and include skin color changes, xerosis, half-and-half nails, and pruritus. The specific disorders include acquired perforating dermatosis, bullous dermatoses, metastatic calcification, and nephrogenic systemic fibrosis. This review article describes these conditions and considers the underlying pathophysiology, clinical presentations, diagnosis, and treatment options.

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Section: Bullous Diseasesmentioning

confidence: 99%

Section: Bullous Diseasesmentioning

confidence: 99%

Cutaneous Manifestations of ESRD

Galperin

Cronin

Leslie

2014

Clinical Journal of the American Society of Nephrology

193

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“…Kalsiflaksi etyolojisinde kalsiyum, fosfat ve paratiroid metabolizmasındaki değişiklikler sorumlu tutulmaktadır 3 . Nefrojen fibröz dermopati ise çok daha nadir olarak görülen spesifik deri bulgularındandır 4,14 . Hastalarımızın hiçbirinde kalsiflaksi ve nefrojen fibröz dermopati saptamadık.…”

Section: Discussionunclassified

Afyonkarahisar ve çevresinde diyalize giren kronik böbrek yetmezlikli hastalardaki deri bulguları

Güder¹,

Karaca²,

Kulaç³

et al. 2012

Turkderm

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ÖzetAmaç: Hemodiyalize giren kronik böbrek yetmezlikli (KBY) hastalardaki deri değişikliklerinin sıklığını değerlendirmek. Gereç ve Yöntem: On sekiz yaş üzerindeki randomize olarak seçilen 100 KBY'li hasta çalışmaya alındı. Hastalar KBY'ye neden olan primer hastalıklar açısından 7 gruba, diyalize girme süreleri açısından da 3 yıl ve daha kısa ve 3 yıldan uzun olarak 2 gruba ayrıldı. Yaş, cinsiyet, hemodiyaliz süresi ve saptanan deri hastalıkları arasındaki ilişki t-testi ve ki-kare testi ile değerlendirildi. Bulgular ortalama değer±standart sapma şeklinde verildi ve p<0,05 ise anlamlı kabul edildi. Bulgular: Hastaların hepsinde en az bir tane olmak üzere birçok deri bulgusu saptandı. En sık karşılaşılan deri değişiklikleri kserozis (%98), tırnak değişiklikleri (%93), melanositik nevus (%78), seboreik keratoz (%54), pigmentasyon değişiklikleri (%51), üremik pruritus (%49), tinea pedis (%34), aktinik keratoz (%23), akrokordon (%16), onikomikoz (%17), lentigo (%16) ve cherry anjiomdu (%11). Tırnak bulgularından en sık dikey sırtlanma, yarım ve yarım tırnak, lunula yokluğu ve splinter hemoraji izlendi. Sonuç: Çeşitli deri değişiklikleri kronik böbrek yetmezliğine sıklıkla eşlik etmektedir. Ayrıntılı bir dermatolojik muayene kronik böbrek yetmezlikli hastaların tanısında önemli bir rol oynayabilir. (Türk derm 2012; 46: 181-5) Anah tar Ke li me ler: Kronik böbrek yetmezliği, hemodiyaliz, deri bulguları Sum maryBackground and Design: To evaluate the prevalence of skin changes in patient with chronic renal failure undergoing hemodialysis. Material and Methods: Over 18 year of age, 100 randomly selected patients were enrolled in the study. The patients were divided into 7 groups in terms of primary disease causing chronic renal failure, and were divided into two groups according to duration of hemodialysis (≤3 years and >3 years). The association of diagnosed skin disorders with age, gender and duration of hemodialysis, were assessed using the t-test and chi-square test. Results are presented as mean±standard deviation and a p value less than 0.05 was considered statistically significant. Results: Many skin diseases, at least one, were found in all patients. The most common skin changes were xerosis (98%), nail changes (93%), melanocytic nevus (78%), seborrheic keratosis (54%), pigmentation changes (51%), uremic pruritus (49%), tinea pedis (34%), actinic keratosis (23%), skin tags (16%), onychomycosis (17%), lentigo (16%), and cherry angioma (11%). The most frequently observed nail changes were longitudinal ridging, half and half nails, absence of lunula and splinter hemorrhages. Conclusion: Various skin changes are often accompanied by chronic renal failure. A detailed dermatological examination may play an important role in the diagnosis of chronic renal failure. (Turk derm 2012; 46: 181-5)

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“…The discoloration also does not fade with pressure. The exact pathophysiological mechanism associated with half and half nails is not understood, but an increase in the number of capillaries and capillary wall thickness has been observed in the nail bed (2). It can be found at any level of azotemia, and does not improve with dialysis; however, it does sometimes improve (and even disappear) with kidney transplantation (3,4).…”

Section: Half and Half Nailsmentioning

confidence: 99%

“…They occur predominantly on the trunk and extensor limb surfaces (2). The incidence in North America ranges between 4.5-10% of patients receiving chronic hemodialysis, however, APD in ESRD has been reported in transplant recipients, and in CKD patients not yet on dialysis, as well (2,11). Although the exact pathophysiological mechanism for APD in ESRD is unknown, it is thought to be the result of dermal connective tissue dysplasia and decay (11).…”

Section: Acquired Perforating Disease Of Hemodialysismentioning

confidence: 99%