Cutaneous Manifestations of Drug Allergy

Kh, Schulz

doi:10.1007/978-3-642-69088-4_4

Cited by 6 publications

(4 citation statements)

References 61 publications

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“…FDE is a pathognomonic dermatosis of drug allergy, which usually repeats itself in the same locations after each new dose of the causative drug or chemically related drugs, although new lesions with similar morphology may appear (11).…”

Section: Discussionmentioning

confidence: 99%

Cross‐reactivity among p‐amino group compounds in sulfonamide fixed drug eruption: diagnostic value of patch testing

et al. 2004

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We studied 28 patients with fixed drug eruption (FDE) caused by sulfonamide antibiotics to investigate cross-reactivity between sulfonamide derivatives and p-amino compounds and to explore the usefulness of patch testing, as an alternative to controlled oral challenge testing (COCT), in diagnosis within this clinical area. COCT with sulfamethoxazole (SMX), sulfadiazine (SDZ), sulfamethizole (SMZ), furosemide (FU), procaine (PRO) and glipizide (GPZ) was performed. Patch testing (PT) with SMX and SDZ was carried out. In all patients, the diagnosis of FDE was confirmed by positive COCT and allergy to trimethoprim ruled out by COCT. 42.8 and 31.8% of the SMX-induced FDE patients reacted to SMZ and SDZ, respectively. All patients (n = 28) tolerated FU, PRO and GPZ. COCT performed with the 3 sulfonamide antibiotics in 12 patients was positive in 2 subjects with the 3 drugs, in 2 patients only with SMX and SMZ and in the remaining 8, SMX was the only causative drug. PT was positive in 5 of 25 patients positive on COCT. The probability of obtaining a positive PT was higher among patients who had a residual lesion than that among those who lacked this. Cross-reactivity between different sulfonamide antibiotics is thus variable, being most likely between SMX and SMZ. We have found no cross-reactivity between sulfonamide antibiotics and other sulfonamide derivatives or p-amino drugs in FDE. PT is a useful tool in the diagnosis of FDE, especially if there are residual lesions, because it avoided the need for COCT in 20% of patients.

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Section: Discussionmentioning

confidence: 99%

Cross‐reactivity among p‐amino group compounds in sulfonamide fixed drug eruption: diagnostic value of patch testing

et al. 2004

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“…There are few reports of oxicam‐induced EM (7–12), and most of these have clinical features of Stevens–Johnson syndrome, which some consider to be a distinct disorder (13, 14), while others propose fixed drug eruption, EM, Stevens–Johnson syndrome and Lyell's syndrome to be a disease spectrum with different degrees of severity (15).…”

Section: Discussionmentioning

confidence: 99%

Piroxicam‐induced erythema multiforme

Prieto¹,

Barrio²,

Pérez³

et al. 2004

Contact Dermatitis

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“…The exact mechanism involved in most non-IgE-mediated allergic drug reactions has not been established. 3 The type I reaction is usually thought of as a true or classic allergic reaction and is the reaction primarily dealt with in this article (see box on page 138). Pseudoallergic reactions are, in general, similar to type I reactions and are therefore included in this subclass.…”

Section: Oassification Of Reactionsmentioning

confidence: 99%

“…3 Type II, III, and N reactions are triggered by non-lgE antibodies, immune complexes, cytotoxic cells, and non-mast cell or nonbasophil mediators. The exact mechanism involved in most non-IgE-mediated allergic drug reactions has not been established.…”

Section: Oassification Of Reactionsmentioning

confidence: 99%

Drug allergy

Volz

Nelson²

1990

Postgraduate Medicine

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The problems in identifying and managing drug allergy are myriad, primarily because of the number of possible agents involved, the lack of objective diagnostic methods, and the varied signs and symptoms that may occur. Allergic reactions can be life-threatening and are avoidable in most cases. A careful and serious approach is important because the effect of medical decisions can be significant. Physicians should keep in mind that an allergic reaction to any drug can occur in any patient at any time.

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Cutaneous Manifestations of Drug Allergy

Cited by 6 publications

References 61 publications

Cross‐reactivity among p‐amino group compounds in sulfonamide fixed drug eruption: diagnostic value of patch testing

Cross‐reactivity among p‐amino group compounds in sulfonamide fixed drug eruption: diagnostic value of patch testing

Piroxicam‐induced erythema multiforme

Drug allergy

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