Cutaneous manifestations of hepatocellular cancer (HCC)

Al-Khazraji, Ahmed

doi:10.1080/17474124.2016.1229182

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…However, the clinical significance of paraneoplastic cutaneous manifestations in HCC is not clear. This is likely due to the low prevalence, compared to the other paraneoplastic phenomena that may accompany HCC 68 .…”

Section: Discussionmentioning

confidence: 99%

“…In these syndromes, patients present with skin abnormalities secondary to the systemic effect of neoplastic cells, which are not related to the underlying liver disease, distant metastasis, or treatment side effects. Previous studies emphasized that paraneoplastic cutaneous manifestations of HCC are more commonly detected in males and in cirrhotic patients 7 , 12 . Other studies indicated associations with particular cutaneous abnormalities and some underlying liver diseases 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies emphasized that paraneoplastic cutaneous manifestations of HCC are more commonly detected in males and in cirrhotic patients 7 , 12 . Other studies indicated associations with particular cutaneous abnormalities and some underlying liver diseases 7 . However, there is a paucity of published data regarding the clinical significance of paraneoplastic cutaneous manifestations in HCC 13 .…”

Section: Introductionmentioning

confidence: 99%

“…While more than half of HCC patients are diagnosed during active surveillance, the other newly diagnosed patients are identified when they present Ivyspring International Publisher with clinical features [6,7]. The presenting clinical features of newly diagnosed HCC patients are highly variable can depend on disease burden and functional status of the liver.…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic Cutaneous Manifestations of Hepatocellular Carcinoma. A Systematic Review and Meta-analysis

Al-Showbaki,

Toubasi,

Jaber

et al. 2024

J. Cancer

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Background: There remains a scarcity of published data on the clinical significance of paraneoplastic cutaneous manifestations in hepatocellular carcinoma (HCC). Method: A systematic search of MEDLINE was performed in December 2022. Inclusion criteria comprised studies reporting on patients with HCC, who had paraneoplastic cutaneous manifestations. Outcomes of interests comprise survival and response to cancer-directed and/or skin directed therapy. Results: A total of 48 studies comprising 60 HCC patients were included in the analysis. The most frequent reported skin abnormalities were dermatomyositis, pityriasis rotunda, and porphyria. Most patients presented with dermatomyositis had underlying viral hepatitis, while all reported porphyria and acanthosis cases were associated with metabolic causes of HCC, such as steatosis. Paraneoplastic skin changes were more common in patients with metastatic disease. Pityriasis Rotunda was associated with the lowest risk of death, (OR: 0.05, 95% CI: 0.003 to 0.89; p = 0.04), while dermatomyositis had a statistically significant higher risk of death (OR: 3.37, 95% CI: 1.01-12.1; p = 0.03). Most patients showed an improvement in their cutaneous abnormalities, following cancer-directed therapy. Conclusion: Paraneoplastic cutaneous manifestations are reported more frequently in patients with a higher burden of disease, especially presence of metastases. Certain cutaneous manifestations have prognostic implication.

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Section: Discussionmentioning

confidence: 99%