Cutaneous Manifestations of Viral Hepatitis

Ahmed, Abdul Baquee; Said, Adnan

doi:10.1007/s11908-014-0452-7

Cited by 18 publications

(10 citation statements)

References 61 publications

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“…Numerous studies have shown that a great number of patients with chronic hepatitis C (40-75%) present extrahepatic manifestations (13). Cacoub et al conducted a study on 1,614 patients with chronic HCV infection and observed that 74% of them had at least one extrahepatic manifestation, arthralgia, paraesthesia and myalgia being the most common symptoms.…”

Section: Hcv Infection and Cutaneous Manifestationsmentioning

confidence: 99%

Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection (Review)

et al. 2018

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Lichen planus (LP) is an immune-mediated inflammatory disease that particularly affects the skin and mucous membranes. Its etiology remains elusive, however some trigger factors, including viral or bacterial antigens, drugs and metals, have been postulated. There is a higher prevalence of hepatitis C virus (HCV) infection among patients with LP, with some geographical variations. HCV is an enveloped RNA virus that belongs to the Flaviviridae family and in most instances causes chronic liver infections. It has been hypothesized that HCV may contribute to LP development, but the link between the two disorders is not fully understood. It is still debatable whether HCV leads to the occurrence of LP lesions directly by replication inside the infected cells or indirectly by activating immunological pathways. Molecular studies have revealed HCV RNA in specimens collected from patients with LP. The autoimmune theory was also suggested given that several studies have revealed viral replication and immune response activation associated with autoantibody synthesis. The aim of this review is to summarize the main potential mechanisms involved in the association between LP and HCV infection. Understanding the link between the two disorders may shed some light on the pathogenesis of LP, which is a challenging issue.

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Section: Hcv Infection and Cutaneous Manifestationsmentioning

confidence: 99%

Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection (Review)

et al. 2018

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“…There are many cutaneous manifestations of chronic HCV infection including necrolytic acral erythema, livedo reticularis, cutaneous leukocytoclastic vasculitis, porphyria cutanea tarda, pruritus, urticaria, lichen planus, polyarteritis nodosa, erythema nodosum, erythema multiforme, pyoderma gangrenosum, and mixed cryoglobulinaemia (MC) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection

Hegab

Sweilam

2015

Dermatology Research and Practice

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Background. Hepatitis C is a global major health problem with extremely variable extrahepatic manifestations. Mixed cryoglobulinaemia (MC) shows a striking association with hepatitis C virus (HCV) infection, and it is sometimes asymptomatic. The skin is a frequently involved target organ in MC. Objective. To investigate the prevalence of cryoglobulinaemia in a sample of Egyptian patients with cutaneous manifestations of chronic HCV infection and to correlate its presence with clinical criteria and liver function tests. Methods. One hundred and eighteen patients with skin manifestations of chronic compensated hepatitis C were included. Venous blood was tested for liver function tests and serum cryoglobulins. Results. Twelve patients (10.169%) were positive for serum cryoglobulins (2 with pruritus, 4 with vasculitic lesions, 3 with livedo reticularis, one with oral lichen, one with chronic urticaria, and another with Schamberg's disease). Vasculitic lesions and livedo reticularis of the legs showed higher prevalence in cryoglobulin-positive than in cryoglobulin-negative patients. Presence of serum cryoglobulins did not relate to patients' demographic or laboratory findings. Conclusions. Fortunately, MC is not markedly prevalent among Egyptians with cutaneous lesions of chronic hepatitis C, and cryopositivity was commonly, but not exclusively, detected with cutaneous vasculitis and livedo reticularis. Laboratory testing for cryoglobulins in every HCV patient is advisable for earlier MC detection and management.

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“…Development of nonorgan‐specific autoantibodies, such as antinuclear antibodies, is well recognized,53, 54, 56, 57, 58 although their clinical significance is debated 54, 59. Finally, some manifestations, such as the cutaneous features of vasculitis and porphyria cutanea tarda described in adults, have not been reported in children 42, 60…”

Section: Clinical Featuresmentioning

confidence: 99%