Cutaneous manifestations of visceral malignancy

Sneddon, I. B.

doi:10.1136/pgmj.46.541.678

Cited by 24 publications

(27 citation statements)

References 69 publications

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“…The benign form (80%) is relatively common and may be associated with obesity, insulin resistance, diabetes mellitus and drug use, contrary to the malignant form, which is rare. 2,3,9-12 …”

Section: Acanthosis Nigricans Malignamentioning

confidence: 99%

“…It begins with symmetrical hyperpigmentation in intertriginous areas such as the axilla, cubital fossa, submammary, inguinal and posterior cervical regions, although any part of the body can be affected (Figure 1). 3,8-10 Lesions then become slightly infiltrated, with velvety hyperkeratotic plaques, commonly surrounded by acrochordons. 3,9 There may be an association with generalized pruritus and involvement of mucosal surfaces, which present a verrucous aspect in severe cases 6,9,11 .…”

Section: Acanthosis Nigricans Malignamentioning

confidence: 99%

“…1,2 In 1868, Hebra was the first to suggest that skin pigmentation could indicate the presence of visceral cancer. 3 Since then, more than 50 dermatological conditions have been reported as potential markers of malignancy. 4 The skin may be directly or indirectly involved in malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic cutaneous manifestations: concepts and updates*

Silva

Mesquita

Igreja

et al. 2013

An. Bras. Dermatol.

151

170

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The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis.

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“…The benign form (80%) is relatively common and may be associated with obesity, insulin resistance, diabetes mellitus and drug use, contrary to the malignant form, which is rare. 2,3,9-12 …”

Section: Acanthosis Nigricans Malignamentioning

confidence: 99%

Section: Acanthosis Nigricans Malignamentioning

confidence: 99%

See 1 more Smart Citation

Paraneoplastic cutaneous manifestations: concepts and updates*

Silva

Mesquita

Igreja

et al. 2013

An. Bras. Dermatol.

151

170

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“…Malign AN düşündüren bulgular şunlardır; deri lezyonlarının hızlı gelişimi, ek paraneoplastik cilt bulgularının olması (seboreik keratoz, Leser-Trelat bulgusu gibi), yaygın tutulumun olması, atipik alanlarda lezyonların olması (muköz membranlar, avuç içi ve ayak tabanı), açıklanamayan kilo kaybının olması ve hastanın ileri yaşta olmasıdır. [15][16][17][18] Hastamız obez değildi, diyabet öyküsü yoktu ve yapılan incelemelerde AKŞ normaldi. Cilt lezyonlarının kısa bir süre içinde çıkması, vücudunun yaygın tutulması, hastanın 40 yaşından büyük olması ve kilo kaybı, sırt ağrısı gibi sistemik semptomlarının da olması nedeniyle malign AN olarak değerlendirildi.…”

Section: Discussionunclassified

The case of gastric adenocarcinoma applying with malign Acanthosis Nigricans

Oruç¹

2015

TJ Oncol

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Achantosis Nigricans (AN) is a skin disorder characterised with hyperpigmented hyperkeratotic lesions. It occurs mostly in association with insulin resistance while it may also arise as a symptom of visceral malignancies. In the occurrence of AN considered as associated with malignancy, a detailed examination may be necessary to identify underlying malignancy. 85% of malign AN cases abdominal adenocarcinomas, and especially 60% of those are gastric adenocarcinomas. A 44-year-old male patient applied to our clinic with hyperpigmentation and hyperkeratosis, widespread body pain and weight loss within 3-4 months. Skin symptoms were reviewed as acanthosis nigricans. He had no endocrinological diseases such as DM or obesity. Due to ocurrence of many skin symptoms in accordance with acanthosis nigricans in a rapid growth on our patient, no findings of other AN causes, systemic symptoms such as the age of patient and weight loss, it is considered as malign AN.Keywords: Acanthosis nigricans.Akantozis Nigrikans (AN), hiperpigmente hiperkeratotik lezyonlarla karakterize bir cilt hastalığıdır. Çoğu insülin resistansı ile ilişkili olmakla birlikte nadiren viseral malignitelerin bir bulgusu olarak da ortaya çıkabilir. Malignite ile ilişkili olduğu düşünülen AN varlığında altta yatan malignensinin saptanması için ayrıntılı inceleme yapılması gerekebilir. Abdominal adenokarsinomalar malign AN olgularının %85'ini özellikle gastrik adenokarsinomalar %60'ını oluşturmaktadır. Kırk dört yaşında erkek hasta üç-dört ay içinde gelişen deride koyulaşma ve kalınlaşma, yaygın vücut ağrısı ve kilo kaybı ile kliniğimize başvurdu. Cilt bulguları AN olarak değerlen-dirildi. Diabetes mellitus, obezite gibi endokrinolojik hastalıklar yoktu. Hastamızda akantozis nigrikans ile uyumlu cilt bulgularının yaygın olması ve hızlı gelişmesi, diğer AN nedenlerinin bulunmaması, hastanın yaşı ve hastada kilo kaybı, yaygın vücut ağrısı gibi sistemik bulgularının da bulunması nedeniyle malign AN olarak değerlendirildi.

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“…Cutaneous metastases from internal carcinoma are a relative rarity, according to several reports [2][3][4][5][6][7][8][9]. In a classic report on cutaneous metastases of malignant disease, Olive Gates [7] in 1937 reported finding 0364-2356/78/0003-0129 $01.00 9 1978 Springer-Verlag New York Inc.…”

Section: Spread Of Carcinoma From Upper Gastrointestinal Tract To Skinmentioning

confidence: 99%

Infrequent patterns of upper gastrointestinal tract malignancy

Smith

1978

Gastrointest Radiol

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The skin and the upper gastrointestinal tract are frequent sites of malignant tumors. However, cutaneous metastasis from primary gastrointestinal tract lesions remains a relative rarity. Similarly rare is spread of primary skin cancer (nonmelanomatous) to upper gastrointestinal tract. This paper presents an unusual example of primary esophageal carcinoma with synchronous skin and bone metastases and a case of squamous cell carcinoma of the stomach, possibly due to spread from a remote squamous cell carcinoma of the skin.

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Cutaneous manifestations of visceral malignancy

Cited by 24 publications

References 69 publications

Paraneoplastic cutaneous manifestations: concepts and updates*

Paraneoplastic cutaneous manifestations: concepts and updates*

The case of gastric adenocarcinoma applying with malign Acanthosis Nigricans

Infrequent patterns of upper gastrointestinal tract malignancy

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