Cutaneous manifestations related to coronavirus disease 2019 (COVID-19): A prospective study from China and Italy

Giorgi, Vincenzo De; Recalcati, Sebastiano; Jia, Ziyi; Wang, Chong; Ding, Renyu; Deng, Yansha; Scarfì, Federica; Venturi, Federico; Trane, Luciana; Gori, Alessia; Silvestri, Flavia; Gao, Xing; Lotti, Torello

doi:10.1016/j.jaad.2020.05.073

Cited by 100 publications

(119 citation statements)

References 5 publications

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“…The incidence of COVID-19 dermatologic manifestation remains unclear, with studies reporting 0.2% to 20%. 8,25,26 There also remains the possibility of bias due to attribution error, given the reliance on providers' judgment in entering data regarding whether findings were virus related, were from a medication, or were from other causes. Although providers were prompted for case updates, most reports represent a single snapshot, preventing full observation of dermatologic manifestations, disease complications, and follow-up testing.…”

Section: Discussionmentioning

confidence: 99%

The spectrum of COVID-19–associated dermatologic manifestations: An international registry of 716 patients from 31 countries

Freeman

McMahon

Lipoff

et al. 2020

Journal of the American Academy of Dermatology

344

536

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Discussionmentioning

confidence: 99%

The spectrum of COVID-19–associated dermatologic manifestations: An international registry of 716 patients from 31 countries

Freeman

McMahon

Lipoff

et al. 2020

Journal of the American Academy of Dermatology

344

536

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“…14,53 De Giorgi et al stated that diffuse petechiae and generalized palpable purpura usually appeared in cases with a greater severity of infection. 17 This statement was supported through a case series conducted in Spain claiming that palpable purpuric lesions, present in 4 of 34 cases (11.8%), were more frequent in middle-aged patients recovering from severe COVID-19 infections. Interestingly, of the four patients presenting with palpable purpuric lesions, two of them additionally exhibited atypical polymorphic papulovesicular eruptions, while a third patient also displayed an urticarial exanthem.…”

Section: Chilblain-like Lesions (Covid Toes)mentioning

confidence: 93%

“…15 Anatomically, the majority of these lesions were located on the trunk of the body. 12,13,[15][16][17][18] Despite a large case series from Spain reporting simultaneous onset of many maculopapular lesions with COVID-19's systemic symptoms, 11 other studies had noticed a later onset in their smaller patient populations. [12][13][14]19 Studies with a later onset of cutaneous manifestations reported average latency times of 27.6 days and 27.85 days.…”

Section: Maculopapular/morbilliform Lesionsmentioning

confidence: 99%

“…93 De Giorgi et al reported spontaneous resolution of inflammatory cutaneous lesions, including vesicular, petechial, and maculopapular lesions. 17 However, Reymundo et al reported use of systemic corticosteroids in six of seven patients in the retrospective study looking into the presence of maculopapular rash. 13 Cordoro et al reported conservative care for patients with livedo-like lesions.…”

Section: Management Considerations Of Cutaneous Manifestations Of Covmentioning

confidence: 99%

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Cutaneous Manifestations of COVID-19: A Systematic Review

Singh

Kaur

Singh

et al. 2021

Advances in Wound Care

133

189

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Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a pandemic. Although pulmonary health has been the primary focus of studies during the early days of COVID-19, development of a comprehensive understanding of this emergent disease requires knowledge of all possible disease manifestations in affected patients. This Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant review focuses on cutaneous manifestations reported in COVID-19 patients. Approach: Literature review was conducted using the PubMed database to examine various cutaneous manifestations related to the SARS-CoV-2 infection. Published articles (n = 56) related to search criteria from the onset of the COVID-19 pandemic to June 30, 2020, were included. The primary literature articles included in this study were mainly from France, Spain, Italy, and the United Kingdom. Results: Unique to many other symptoms of COVID-19, its cutaneous manifestations have been found in people of all age groups, including children. The cutaneous manifestations of COVID-19 are varied and include maculopapular, chilblain-like, urticarial, vesicular, livedoid, and petechial lesions. In addition, rashes are common in multisystem inflammatory syndrome in children, a new and serious health condition that shares symptoms with Kawasaki disease and is likely related to COVID-19. In addition, personal protective equipmentrelated skin wounds are of serious concern since broken cutaneous barriers can create an opening for potential COVID-19 infections. Innovation and Conclusion: As this virus continues to spread silently, mainly through asymptomatic carriers, an accurate and rapid identification of these cutaneous manifestations may be vital to early diagnosis and lead to possible better prognosis in COVID-19 patients. This systematic review and photo atlas provide a detailed analysis of the skin pathologies related to COVID-19. Study of these cutaneous manifestations and their pathogenesis, as well their significance in human health will help define COVID-19 in its entirety, which is a prerequisite to its effective management.

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“…В настоящее время имеется достаточно научных работ, описывающих кожные проявления, ассоциируемые с COVID-19. Предложены алгоритмы диагностики дерматологических симптомов [4][5][6]. Многообразие клинической картины кожных проявлений коронавирусной инфекции требует глубокого анализа с целью правильной интерпретации и дифференциальной диагностики поражений кожного покрова при COVID-19 и других инфекционных экзантем, и дерматозов.…”

unclassified

The Dermatological Manifestations in the Coronavirus Infection COVID-19

Дворников

Силин

Гайдина

et al. 2020

Arhivʺ vnutrennej mediciny

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The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

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Cutaneous manifestations related to coronavirus disease 2019 (COVID-19): A prospective study from China and Italy

Cited by 100 publications

References 5 publications

The spectrum of COVID-19–associated dermatologic manifestations: An international registry of 716 patients from 31 countries

The spectrum of COVID-19–associated dermatologic manifestations: An international registry of 716 patients from 31 countries

Cutaneous Manifestations of COVID-19: A Systematic Review

The Dermatological Manifestations in the Coronavirus Infection COVID-19

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