Cutaneous mantle cell lymphoma: a clinicopathologic review of 10 cases

Gru, Alejandro A.; Hurley, M. Yadira; Salavaggione, Andrea L.; Brodell, Lindsey A.; Sheinbein, David; Anadkat, Milan J.; Porcu, Pierluigi; Frater, John L.

doi:10.1111/cup.12802

Cited by 14 publications

(12 citation statements)

References 41 publications

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“…MCL uncommonly involves the skin and is typically a dermal‐based infiltrate with secondary pannicular involvement . While the clinical presentation of subcutaneous tender nodules in a patient with known widespread systemic disease is consistent with some reported cases of cutaneous MCL, the histomorphologic pattern observed in this case is exceptional, as the neoplastic infiltrate had preferential involvement of the subcutaneous tissue, with prominent rimming of individual adipocytes. These morphologic features are typical of SPTCL.…”

Section: Discussionsupporting

confidence: 85%

“…It is characterized by a distinct rearrangement of t(11;14)(q13;q32) that juxtaposes the CCND1 gene on chromosome 11 with the immunoglobulin heavy gene on chromosome 14, leading to overexpression of the Cyclin D1 protein . The classic histomorphology of cutaneous MCL is described as a monotonous population of small to medium‐sized lymphocytes with slightly irregular nuclear borders, coarse chromatin, and scant cytoplasm with co‐expression of CD5, SOX11, FMC7, and cyclin D1 . Extranodal spread to the spleen, gastrointestinal tract, and bone marrow is common, however, cutaneous involvement by MCL is found only in 1% of cases, often representing widespread systemic disease associated with an aggressive clinical course .…”

Section: Introductionmentioning

confidence: 99%

“…Extranodal spread to the spleen, gastrointestinal tract, and bone marrow is common, however, cutaneous involvement by MCL is found only in 1% of cases, often representing widespread systemic disease associated with an aggressive clinical course . In reported cases in the literature, the malignant lymphoid infiltrate of MCL can involve the subcutaneous tissue, perivascular and periadnexal structures, but is consistently centered in the dermis with sparing of the epidermis …”

Section: Introductionmentioning

confidence: 99%

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Cutaneous mantle cell lymphoma histomorphologically mimicking subcutaneous panniculitis‐like T‐cell lymphoma: Case report

et al. 2019

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Secondary cutaneous involvement by mantle cell lymphoma (MCL), an uncommon aggressive B-cell malignancy, predominantly involves the dermis, with few reports of pannicular involvement. Lymphocytic infiltration of subcutaneous tissue is associated with /journal/cup J Cutan Pathol. 2019;46:538-541.sone, and rituximab or a rituximab-bendamustine induction therapy, followed by maintenance rituximab. 14 While cutaneous lesions may be the initial site of clinical detection of disease, 3 primary (skin only) cutaneous MCL has not been convincingly documented in the literature and all patients presenting with cutaneous MCL warrant work-up for widespread disease. It is therefore imperative to differentiate cutaneous involvement of MCL from benign inflammatory conditions and other, more indolent, cutaneous lymphomas. MCL can promptly be distinguished through immunophenotyping, primarily with staining for cyclin D1 and SOX11. Further confirmation may be obtained with molecular genetics (CCND1/IgH fusion by FISH).Adipotropism by SPTCL is thought to reflect a unique interaction between CCL-5 positive lymphocytes and CCR5 positive adipocytes. 15 We postulate that the current case involves interaction between the unique microenvironment of adipose tissue and neoplastic cells, leading to the preferential involvement of the infiltration into the adipose tissue.Of the genetic alternations identified through sequencing our patient's tumor cells, it is interesting that mTOR is implicated in adipogenesis, adipocyte maturation, adipocyte terminal differentiation, as well as key roles in regulating endocrine functions of adipose tissue. 16 Alterations in mTOR are not specific to MCL and mutations are implicated in many other types of lymphomas and neoplasms. 17 The complex and central role that mTOR plays in adipose homeostasis may link our tumor to its preference to the adipose tissue, although further investigation is warranted regarding specific genomic alterations in lymphomas and the implications these mutations have in the involvement of tumor cells with cutaneous and adipose environments. While morphologic features of SPTCL, specifically rimming of adipocytes by neoplastic lymphoid cells, have been documented in other type of lymphomas, this case is exceptional in that the morphologic features of SPTCL are showed in secondary cutaneous involvement by MCL. The rare panniculitis-like presentation of aggressive B-cell lymphomas represents a potential pitfall for pathologists anddermatopathologists. This case supports the common practice of routinely using specific immunohistochemical staining, and/or molecular cytogenetics, for all cases of panniculitis-type lymphomas. Further research is warranted to describe the full spectrum of cutaneous Bcell lymphomas that present with panniculitis-like features. ORCIDCaroline Laggis https://orcid.org/0000-0003-3819-9345

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous mantle cell lymphoma histomorphologically mimicking subcutaneous panniculitis‐like T‐cell lymphoma: Case report

et al. 2019

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“…Skin infiltrates only occur in mantle cell lymphomas (MCLs) in around 1 % of cases, with no primary cutaneous manifestations [4,5]. Since the diagnosis can be made based on histological examination of skin biopsies in 20-55 % of cases (as in our case), dermatologists have an important role, as they perform skin biopsies if indicated [5,6]. Mantle cell lymphomas occur predominantly in older men and have a poor prognosis.…”

Section: Discussionmentioning

confidence: 97%

Fast growing nodules on the arm and penis

Kaune

Zutt

Plumbaum

et al. 2021

J Deutsche Derma Gesell

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Medical history and clinical findingsAn 81-year-old patient presented with rapidly growing, livid-erythematous, hard palpable nodes on the left upper arm, elbow and forearm as well as on the glans penis that had appeared a few weeks previously (Figure 1). The patient had B symptoms with weight loss and night sweats. As previous illnesses he reported coronary heart disease with a previous myocardial infarction, as well as hypertension and insulin-dependent diabetes. Our differential diagnoses with regard to the nodes included juxta-articular nodes resulting from borreliosis, adnexal tumors, cutaneous lymphomas as well as secondary cutaneous metastases from a systemic neoplasm.

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“…From a differential diagnosis, other cutaneous lymphoproliferative disorders, that are CD5+ should also be included in the differential diagnosis: to this extent, mantle cell lymphoma (MCL) is a systemic form of B‐cell malignancy that can sometimes involve the skin 8,9 . As opposed to CLL, mantle cell lymphoma is typically CD23 and CD43 negative.…”

Section: Figurementioning

confidence: 99%