Cutaneous marginal zone lymphoma of the nose arising after rhinoplasty with filler injection

Abstract

Chronic inflammation induced by infection, autoimmune disorders, and immune reaction against foreign bodies are recognized as causative factors for the development of lymphoma. Here, a case of B cell lymphoma arising after augmentation rhinoplasty with filler injection is reported. A 48-year-old Japanese woman underwent rhinoplasty with filler injection at a cosmetic clinic 10 years ago. She, presently, came with complaints of a nodule at the nasal root. Histologic examination of the biopsy specimen revealed diffuse infiltration of centrocyte-like cells with plasmacytic differentiation in the subcutis and procerus muscle. Immunohistochemistry showed that the tumor cells were CD3−, CD5−, CD10−, CD20+, CD79+, bcl-2+, bcl-10+, IgG+, IgA −, and IgM−. In situ hybridization for Epstein-Barr virus small RNAs was negative. The final diagnosis was extranodal marginal zone lymphoma. This is a case of foreign body-induced carcinogenesis. Various aspects of chronic inflammation that propel lymphoma development are discussed with their morphology, immunophenotype, and viral association.

B-Cell Lymphoma Arising From a Nasal Implant: A Brief Clinical Study

“…Many studies have been conducted to compare various approaches to the zygomatic bone fractures. [3][4][5] Gillies temporal approach has been widely used to reduce zygoma fractures. [6][7][8][9] Traditionally, it is the preferred method to reduce the isolated zygomatic arch fracture.…”

“…On the contrary, lymphoma caused by intranasal foreign implants has not been reported to our knowledge. Only a single case of cutaneous marginal zone lymphoma of the nose arising after a filler injection was reported in Japan 3 . In this article, we present a rare case of a 49-year-old Asian woman afflicted with B-cell lymphoma 20 years after an intranasal silicone implant had been inserted for dorsal augmentation during a rhinoplasty procedure.…”

“…Only a single case of cutaneous marginal zone lymphoma of the nose arising after a filler injection was reported in Japan. 3 In this article, we present a rare case of a 49year-old Asian woman afflicted with B-cell lymphoma 20 years after an intranasal silicone implant had been inserted for dorsal augmentation during a rhinoplasty procedure. Furthermore, we discuss the possible pathogenesis for the development of lymphoma in our case.…”