Cutaneous Mastocytosis in a Dog

Davis, Brad J.; Page, Rodney L.; Sannes, Philip L.; Meuten, Donald J.

doi:10.1177/030098589202900415

Cited by 32 publications

(60 citation statements)

References 4 publications

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“…Maculopapular CM, historically termed “urticaria pigmentosa”, is the most common form of CM in humans characterized by typical brown discolouration of the disseminated maculopapular lesions . Rare reports about CM in dogs exist and revealed heterogeneous clinical presentations; dogs exhibited maculopapular lesions, plaques or nodules that were brownish, pale or erythematous . The reports commonly used the umbrella term “urticaria pigmentosa‐like” disease when the lesions were nonpigmented.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the release of mast cell mediators, patients with CM can experience severe pruritus. Rare cases describing a disease in dogs that resembles human CM have been reported and they have been referred to as ‘mastocytosis’ to differentiate them from ‘true’ mast cell tumours (MCT) . Oral H1 antihistamines successfully controlled pruritus in these animals.…”

Section: Introductionmentioning

confidence: 99%

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Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis

Meichner

Kiupel

Kasantikul

et al. 2018

Veterinary Dermatology

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Background Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus. Hypothesis/Objective To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog. Animal A 4‐year‐old, spayed female cross‐bred dog presented with severely pruritic, erythematous to pigmented macules and papules involving the ventral abdomen, interdigital skin, perivulval area and both pinnae; the pruritus had been unresponsive to treatment with antihistamines, prednisone and ciclosporin. Methods and materials Complete blood count and serum biochemistry, abdominal ultrasound, blood smear and skin cytological evaluation, PCR, histopathological and immunohistochemical examination of skin biopsies. Results Skin cytological evaluation revealed high numbers of uniform, heavily granulated mast cells; histopathological findings showed focal dermal proliferations of well‐differentiated, uniform mast cells consistent with a low‐grade mast cell tumour (MCT). Clinical staging revealed that the disease was confined to the skin. Mutations of c‐kit exon 8 and 11 were not detected. Treatment was initiated with anti‐canine‐interleukin (IL)‐31 monoclonal antibody lokivetmab; antihistamines were continued. The dog's pruritus resolved within seven days and was maintained in remission over 15 months with once monthly lokivetmab injections; the skin lesions improved but did not resolve. Conclusion and clinical importance Lokivetmab treatment was effective in resolving and maintaining pruritus remission in this dog with widespread cutaneous mast cell disease. Whether CM in dogs represent a separate entity that should be distinguished from a low‐grade MCT requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis

Meichner

Kiupel

Kasantikul

et al. 2018

Veterinary Dermatology

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“…A idade de acometimento também foi equivalente a reportada na literatura (Patnaik et al 1984, Baker-Gabb et al 2003, Dobson & Scase 2007, sendo a média encontrada de 7,6 anos (+/-2,38). Apenas um cão apresentava dois anos de idade, mostrando que o tumor pode ocorrer também em animais mais jovens (Davis et al 1992). Quanto à predisposição sexual, este estudo não mostrou predileção, corroborando com informações descritas anteriormente (Patnaik et al 1984, Baker-Gabb et al 2003, Bronden et al 2010).…”

Section: Discussionunclassified

Tomografia computadorizada de mastocitomas em cães: avaliação pré e pós-tratamento quimioterápico

et al. 2013

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Foram avaliados, por meio da tomografia computadorizada, 19 cães com mastocitomas tratados com quimioterapia. Aspectos como contorno, atenuação, realce pós-contraste e presença de clivagem com estruturas adjacentes foram avaliados. Aplicaram-se os critérios RECIST e a mensuração volumétrica das lesões para se avaliar a resposta ao tratamento. Quanto à atenuação, os mastocitomas se mostraram como lesões homogêneas ou heterogêneas, com tendência a limites definidos e contornos regulares e apresentaram realce moderado após administração do contraste iodado intravenoso. Os métodos RECIST e a mensuração volumétrica apresentaram uma excelente concordância na classificação da resposta terapêutica, fornecendo um bom parâmetro da resposta ao tratamento instituído. O exame de tomografia computadorizada se mostrou útil na delimitação do tumor e importante ferramenta no planejamento das margens cirúrgicas.

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“…Canine MCTs (CMCTs) are generally originated from cutaneous apparatus, and the advanced stage of several malignant forms shared several features of human systemic mastocytosis (Table 1) [48,49]. CMCTs are the most common skin canine neoplasm, representing 7-25% of all skin tumors and 11-27% of the malignant skin neoplasms in this species [50,51].…”

Section: Canine Mast Cell Tumors (Cmcts)mentioning

confidence: 99%