Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation

Abstract

Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMTCT) is a recently described dermally based neoplasm with melanocytic differentiation. It can easily be confused with clear cell sarcoma and metastatic melanoma. Our understanding of this lesion, including its potential for aggressive disease, has been limited by the small number of previously reported cases (13) and the limited clinical follow-up data. Here, we report a series of 41 CMTCT confirmed by molecular studies. We find that the lesion shows highly uniform and reproducible morphologic, immunohistochemical, and genetic features across a wide variety of anatomic locations and age groups. Among 22 cases with follow-up, 1 local recurrence and 1 nodal metastasis were identified. Our data support the classification of CMTCT as a unique nosologic entity and emphasize the importance of distinguishing this entity from its histologic mimics, especially clear cell sarcoma and metastatic melanoma, to guide therapy and establish accurate prognostic expectations.

Clear cell tumor with melanocytic differentiation and MITF::CREM translocation

“…Several new tumors with melanocytic differentiation have been described in recent years. First is cutaneous melanocytic tumor with CRTC1::TRIM11 fusion, a dermally based neoplasm that can be easily confused with CCS or melanoma, especially metastatic melanoma 6–9 . Second is clear cell tumor with melanocytic differentiation and ACTIN::MITF translocation 10 .…”

“…First is cutaneous melanocytic tumor with CRTC1::TRIM11 fusion, a dermally based neoplasm that can be easily confused with CCS or melanoma, especially metastatic melanoma. [6][7][8][9] Second is clear cell tumor with melanocytic differentiation and ACTIN::MITF translocation. 10 Melanocytic differentiation in this dermally based tumor is probably attributable to hyperactive MITF function owing to the gene fusion.…”

TRIM11 promotes cell proliferation of non‐small cell lung cancer through the inhibition of ferroptosis by AMPK

“…18 The TRIM11 protein, a member of the TRIM family, is involved in regulating cell apoptosis, proliferation, and cell cycle. 19 As a tumor promoting factor, TRIM11 can enhance tumor cell proliferation and invasion through various mechanisms. 20 High expression of TRIM11 was observed in advanced stage gliomas, while low expression was associated with poor differentiation and favorable prognosis.…”

“…The TRIM11 protein, a member of the TRIM family, is involved in regulating cell apoptosis, proliferation, and cell cycle 19 . As a tumor promoting factor, TRIM11 can enhance tumor cell proliferation and invasion through various mechanisms 20 .…”

NONO::TFE3 fusion cutaneous epithelioid and spindle cell tumor: A case series

“…Thus, molecular studies were utilized showing the presence of the NONO::TFE3 fusion excluding these other entities. Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion is a recently described dermal tumor with melanocytic differentiation characterized by SOX10 and S100 positivity and focal Melan-A and HMB-45 expression 18. Clear cell tumor with MITF::CREM fusion is also a newly described entity characterized by a dermal proliferation of clear vacuolated cells diffusely expressing S100, SOX10, and Melan-A with focal expression of HMB-45.19 While we believe the morphology and molecular findings of our two cases fit PEComa best, the unusual immunophenotype, particularly the SOX10 and p63 positivity, also made us entertain the possibility that these two cases might be a novel previously undescribed subtype of primary cutaneous fusion tumor with some melanocytic and/or myoepithelial differentiation.…”