Cutaneous melanoma in postmenopausal women after nonmelanoma skin carcinoma

Rosenberg, Carol A.; Khandekar, Janardan D.; Greenland, Philip; Rodabough, Rebecca J.; McTiernan, Anne

doi:10.1002/cncr.21627

Cited by 15 publications

(7 citation statements)

References 57 publications

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“…It is interesting to note that we identified 2 previously unreported risk factors that were associated with melanoma metastasis: a history of nonmelanoma skin cancer and a history of cancer other than skin cancer. Other studies 13,14 have indicated that there is an increased incidence of melanoma in patients who have a previous history of nonmelanoma skin cancer; however, to our knowledge, no previous investigators have observed such an increased risk of metastasis. In addition, although there have been no reports examining the risk of melanoma metastasis specifically, a prospective study by Kahn et al 15 indicated that individuals who have a history of nonmelanoma skin cancer are at increased risk of cancer mortality, including melanoma.…”

Section: Discussionmentioning

confidence: 60%

Characteristics associated with early and late melanoma metastases

Brauer

Wriston

Troxel

et al. 2009

Cancer

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BACKGROUND: Differences in risk factors for metastases at different time intervals after treatment have been described in several malignancies; however, to the authors' knowledge, no extensive study examining this issue in melanoma has been conducted to date. METHODS: The authors performed a nested case-control study of patients with melanoma who presented with only local disease. Patients in the case group included 549 patients who developed metastases 6 months after surgery. Of these, 320 patients developed metastasis within 3 years after undergoing definitive surgery (early metastases [EM]), and 70 patients developed metastasis 8 years after undergoing definitive surgery (late metastases [LM]). For each case, a control patient was chosen who had melanoma but who did not develop metastases in the same interval. Univariate and conditional multivariate logistic regression were used in the analysis of 34 clinical and tumor characteristics. RESULTS: Multivariate analysis confirmed previously established risk factors for metastases, such as increasing tumor thickness. In addition, the authors discovered that a personal history of nonmelanoma skin cancer (P ¼ .006) and a history of cancer other than skin cancer (P ¼ .020) also were associated with metastasis. In comparing the 320 EM patients with the 70 LM patients, EM patients were more likely to have thicker lesions (P < .001), ulcerated lesions (P ¼ .016), and a history of nonmelanoma skin cancer (P ¼ .024). CONCLUSIONS: In this study, 2 potentially novel risk factors for melanoma metastases were identified, and different profiles of risk factors were constructed for EM versus LM. These differences may be important in future risk identification and stratification for clinical trials and for the management and treatment of patients with melanoma.

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Section: Discussionmentioning

confidence: 60%

Characteristics associated with early and late melanoma metastases

Brauer

Wriston

Troxel

et al. 2009

Cancer

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“…On the other hand, patients with a personal basal cell carcinoma or squamous cell carcinoma history is also associated with an increased the melanoma risk. According to studies [32][33], this risk varies from a non-significant increase for the melanoma with a squamous cell carcinoma history of 1.04 (CI 0.13-8.18) at a significant risk of 7.94 .In our study, no history of malignant melanoma or skin cancer was documented.…”

Section: Sex Mencontrasting

confidence: 40%

Cutaneous Malignant Melanomas: Epidemiological, Clinical and Therapeutic Aspects. Experience of the Plastic Surgery Department in Mohammed Vi Hospital of Marrakech- Morocco.

Dhaidah¹,

Sahibi²,

Bhihi³

et al. 2018

IJAR

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CTLA4 monoclonal antibodies and targeted therapy with inhibitors of BRAF or MEK for melanoma with BRAF mutated, recent studies have shown that the combination of inhibitors of BRAF and inhibitors of MEK may improve the progression-free survival and eventually increase overall survival, the choice of therapy should be individualized in each case depending on various factors such as BRAF mutation status, age, co-morbidities and topography of metastases ,while chemotherapy and radiation therapy can be used to relieve the symptoms without significant impact on patient survival. Preventing melanoma is a real public health problem requires education of the general population on the need for sunscreen and awareness of melanoma and encouraging early diagnosis with the training of health professionals.

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“…For the former, participants who did not develop melanoma or who died during the study period were censored at death, last follow-up date, or end of study, whichever occurred first. Melanoma was centrally adjudicated as described in previous studies [14, 15]; NMSC was obtained from self-report from yearly follow-up.…”

Section: Methodsmentioning

confidence: 99%

Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative

Kubo

Henderson

Desai

et al. 2013

Cancer Causes Control

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Purpose The relationship between alcohol consumption and preference of alcohol type with hazard of melanoma (MM) and risk of non-melanoma skin cancer (NMSC) was examined in the Women's Health Initiative (WHI) Observational Study (OS). Methods A prospective cohort of 59,575 White postmenopausal women in the WHI OS (mean age 63.6) was analyzed. Cox proportional hazards models and logistic regression techniques were used to assess the hazard and risk of physician-adjudicated MM and self-reported NMSC, respectively, after adjusting for potential confounders including measures of sun exposure and skin type. Results Over 10.2 mean years of follow-up, 532 MM cases and 9,593 NMSC cases occurred. A significant relationship between amount of alcohol consumed and both MM and NMSC was observed, with those who consume 7+ drinks per week having a higher hazard of MM (HR 1.64 (1.09, 2.49), pglobal = 0.0013) and higher risk of NMSC (OR 1.23 (1.11, 1.36), pglobal < 0.0001) compared to non-drinkers. Lifetime alcohol consumption was also positively associated with hazard of MM (p = 0.0011) and risk of NMSC (p < 0.0001). Further, compared to non-drinkers, a preference for either white wine or liquor was associated with an increased hazard of MM (HR 1.52 (1.02, 2.27) for white wine; HR 1.65 (1.07, 2.55) for liquor) and risk of NMSC (OR 1.16 (1.05, 1.28) for white wine; OR 1.26 (1.13, 1.41) for liquor). Conclusions Higher current alcohol consumption, higher lifetime alcohol consumption, and a preference for white wine or liquor were associated with increased hazard of MM and risk of NMSC.

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Cutaneous melanoma in postmenopausal women after nonmelanoma skin carcinoma

Cited by 15 publications

References 57 publications

Characteristics associated with early and late melanoma metastases

Characteristics associated with early and late melanoma metastases

Cutaneous Malignant Melanomas: Epidemiological, Clinical and Therapeutic Aspects. Experience of the Plastic Surgery Department in Mohammed Vi Hospital of Marrakech- Morocco.

Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative

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