Cutaneous meningioma: A cytomorphological diagnosis

Kishore, Manjari; Bhardwaj, ManjuKaushal Minakshi; Sharma, Neha

doi:10.4103/idoj.idoj_169_16

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…Cutaneous meningioma is usually seen in the scalp and is believed to originate from a rudimentary meningocele. 6 Furthermore, CD34 expression along with the absence of EMA and PR expression make that diagnosis less likely in the current case.…”

Section: Discussionmentioning

confidence: 79%

Co-expression of CD34 and h-caldesmon in a benign meningioma-like dermal neoplasm, a case report

Kussaibi

2020

Dermatol Reports

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Meningioma-like dermal tumor with diffuse coexpression of CD34 and hcaldesmon is rarely reported. Herein, we report a case of a 58-years-old woman who complained of a solitary dome-shaped papule on the left hand. An ellipse of skin measuring 1 x 0.5 x 0.5 cm was excised and sent for histopathological evaluation. Upon sectioning, the specimen showed a whitish firm dermal nodule measuring 3 mm in its greatest dimension. Microscopic examination revealed a well-circumscribed barely encapsulated dermal lesion showing compact round whorled sheets formed of round to ovoid uniform cells with abundant pink cytoplasm. Occasional intranuclear vacuoles were seen. A minor capillary-sized vascular component was seen in the background. Immunohistochemical (IHC) study revealed a diffuse positivity of tumor cells to CD34 and h-caldesmon along with faint reaction to Smooth Muscle Actin (SMA) and ER. However, Desmin, S100, HMB45, EMA, Pan Cytokeratin, and Chromogranin were all negative. Ki67 was very low (1%). The main differential diagnoses of the current lesion are meningioma and glomus family tumors. While the current lesion is morphologically reminiscent of cutaneous meningioma; neither the location nor the IHC stains support that diagnosis. The glomus family is highly suggestive. However, the location, the compact nature of the proliferation, and the positivity of CD34, all are unusual in such entities.

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Section: Discussionmentioning

confidence: 79%

Co-expression of CD34 and h-caldesmon in a benign meningioma-like dermal neoplasm, a case report

Kussaibi

2020

Dermatol Reports

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“…The larger ovoid cells may be distributed in sheets, giving rise to a syncytial appearance 7 . Nuclear grooves and psammoma bodies with or without calcification are also often present in these lesions 9,10 . Type II and III meningiomas carry a worse prognosis than type I 9 …”

Section: Discussionmentioning

confidence: 99%

“…7 Nuclear grooves and psammoma bodies with or without calcification are also often present in these lesions. 9,10 Type II and III meningiomas carry a worse prognosis than type I. 9 Meningiomas can show overlapping morphology with other spindle cell tumors, such as sarcomatous squamous cell carcinoma, schwannoma, cellular neurothekeoma, dermatofibrosarcoma protuberans, perineurioma, leiomyosarcoma, solitary fibrous tumor (hemangiopericytoma), and melanoma.…”

Section: Case Studymentioning

confidence: 99%

Type III cutaneous atypical meningioma of the scalp

Anderson

Alhatem

et al. 2022

J Cutan Pathol

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Meningiomas occur rarely in extracranial sites, including the skin, where they may pose a diagnostic challenge because of their histopathologic overlap with several other spindle-cell tumors. Cutaneous meningiomas are divided into type I (congenital), type II (ectopic), and type III (via direct extension) lesions. We present a rare case of atypical meningioma of the skin in a 71-year-old woman who presented with a painful and enlarging lesion on the left central frontal scalp. Biopsy showed bone and soft tissue with involvement of a spindle cell neoplasm, consisting of whorled nests with atypical features, including variably increased mitotic index, areas of hypercellularity, and sheeted architecture. The overall findings were consistent with an atypical meningioma (World Health Organization grade 2). Atypical meningiomas constitute only 5% to 15% of all meningiomas. Magnetic resonance imaging of the skull later demonstrated a left frontal tumor consistent with an atypical meningioma that had eroded through the skull. Dermatopathologists should consider cutaneous meningioma as a differential diagnosis of spindle-cell neoplasms of the skin and subcutaneous tissue in head and neck.

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“…12,14 After intensive search, we found 8 other reported cases of cutaneous meningioma in the Indian literature, out of which 7 were located in the scalp and one in the submandibular region. 1,13,[15][16][17][18][19][20] This is the 4 t h Indian case of Rudimentary meningocele and the 1 st case of RM to be located in the spine in the Indian literature.…”

Section: Discussionmentioning

confidence: 99%

Type I cutaneous meningioma of dorsal thoracic spine (Rudimentary Meningocele): A rare entity at an unusual site

Kripalani¹,

Jagdale

Pol³

et al. 2021

JDPO

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Cutaneous meningiomas (CM) are rare variants of meningiomas which are further classified into three subtypes. Type I CM (TICM) or Rudimentary meningocele (RM) is an uncommon developmental anomaly in which meningothelial elements are displaced into the skin and soft tissue. We present a case of 11 year boy with an upper back swelling since early childhood. His MRI spine showed a lesion at T4-T7 level with a fistulous tract connecting it to dural sac. Histopathology revealed clusters of oval to spindle cells arranged in whorls amidst collagen bundles and psammoma bodies. On immunohistochemistry these cells expressed EMA and Vimentin. A diagnosis of TICM was rendered based on these characteristic clinico-radiological & histopathological features. TICM pose a diagnostic challenge clinically and histopathologically and have an excellent prognosis. This is the 4 Indian case of RM and the 1 case of RM to be located in the spine in the Indian literature.

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Cutaneous meningioma: A cytomorphological diagnosis

Cited by 6 publications

References 10 publications

Co-expression of CD34 and h-caldesmon in a benign meningioma-like dermal neoplasm, a case report

Co-expression of CD34 and h-caldesmon in a benign meningioma-like dermal neoplasm, a case report

Type III cutaneous atypical meningioma of the scalp

Type I cutaneous meningioma of dorsal thoracic spine (Rudimentary Meningocele): A rare entity at an unusual site

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