Cutaneous metastases from carcinoma breast: The common and the rare

Prabhu, Smitha; Pai, Sathish B; Sripathi, H; Kudur, Mohan H; Vasanth, Vani

doi:10.4103/0378-6323.55395

Cited by 37 publications

(49 citation statements)

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“…[23] Scalp nodules in patient number 6 (ER 100%) were one of the clinical findings and thought to be either multiple furunculosis or metastatic. The scalp nodules were 18 F-FDG-positive but this did not solve the problem.…”

Section: Discussionmentioning

confidence: 99%

Can 18F-Fluoroestradiol positron emission tomography become a new imaging standard in the estrogen receptor-positive breast cancer patient: A prospective comparative study with 18F-Fluorodeoxyglucose positron emission tomography?

et al. 2017

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Correct staging is the most crucial for the treatment outcome in cancer management. Molecular imaging with 18F-fluoroestradiol (FES) positron emission tomography-computed tomography (PET-CT) targets estrogen receptor (ER) and may have a higher incremental value in diagnosis by aiding specificity. We enrolled 12 female breast cancer patients prospectively and did 18F-FES PET-CT and 18F-fluorodeoxyglucose (FDG) PET-CT within 1 week interval time. Lesion detection sensitivity was compared for a total number of lesions and for nonhepatic lesions only by McNemar test. 18F-FES PET-CT was taken as reference in case of indeterminate lesions. The incremental value reported by identifying 18F-FES exclusive lesions and by characterization of 18F-FDG indeterminate lesions. Spearman rank test was used to correlate ER expression and maximum standardized uptake value (SUVmax). Two ER-negative patients with no 18F-FES uptake were excluded. Ten ER-positive patients with 154 disease lesions were finally analyzed. 18F-FDG picked-up 142 lesions (sensitivity 92.21%), whereas 18F-FES picked-up 116 lesions (sensitivity 75.32%) and this difference was statistically significant. For nonhepatic lesions (n = 136) detectability, 18F-FDG picked-up 124 (sensitivity 91.18%), whereas 18F-FES picked-up 116 (sensitivity 85.29%) lesions and this difference was not statistically significant. Beside 12 exclusive lesions, 18F-FES characterized 41 (27.5%) 18F-FDG indeterminate lesions. Overall 18F-FES impacted 20% patient management. The positive trend was also seen with 18F-FES SUVmax with ER expression and negative with 18F-FDG SUVmax. We conclude, 18F-FDG has overall better sensitivity than 18F-FES PET-CT, however for nonhepatic metastasis difference was not significant. 18F-FES PET-CT better-characterized lesions and impacted 20% patient management. Therefore, 18F-FES PET-CT should be used with 18F-FDG PET-CT in strongly ER expressing patients for better specificity.

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Section: Discussionmentioning

confidence: 99%

Can 18F-Fluoroestradiol positron emission tomography become a new imaging standard in the estrogen receptor-positive breast cancer patient: A prospective comparative study with 18F-Fluorodeoxyglucose positron emission tomography?

et al. 2017

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“…In women, it occurs most commonly in breast cancer in contrast to men, where it occurs most often in melanoma [3].…”

Section: Discussionmentioning

confidence: 99%

“…In this case; the lesions were situated on the anterior chest wall and covered both above and below the operative scar suggesting the direct spread from the carcinoma breast. CE is usually associated with intraductal breast carcinoma and is often considered a marker of tumor recurrence with omnious prognosis [3]. The metastasis occurs due to a rapid spread of tumor along subdermal lymphatic vessels leading to blockade and erythema [7].…”

Section: Discussionmentioning

confidence: 99%

Carcinoma erysipeloides mimicking radiation dermatitis – a case report and review of literature

Sharma¹,

Kaur²,

Garg³

et al. 2014

Our Dermatol Online

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Carcinoma erysipeloides (CE) is a relatively rare variant of cutaneous metastasis more often observed in breast cancer than in other carcinomas in women. Clinically, it appears as a well-defined, warm and tender inflammatory erythematous plaque, thus mimicking Erysipelas, Cellulitis or post mastectomy complications of lymphedema and acute radiation dermatitis. We report a case of CE in a women previously treated for infiltrating ductal carcinoma by modified radical mastectomy, chemotherapy and radiotherapy. An early and accurate differential diagnosis of this disease gives the opportunity to diagnose and halt the systemic spread of the cancer.

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“…In the minority of cases, metastasis may be discovered at the same time or prior to the diagnosis of carcinoma. Breast cancer is one of the most common malignancies to spread to the skin (28,29). It is estimated that 30% of breast cancers have the tendency to metastasize.…”

Section: A B C D Ementioning

confidence: 99%

Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature

et al. 2015

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Abstract. Desmoplastic trichoepithelioma (DTE) is a rare benign adnexal tumor with the characteristic features of asymptomatic, solitary, annular, indurated and centrally depressed papules or plaques, most commonly occurring in younger individuals on the face. Microscopically and clinically, DTE may be difficult to distinguish from other cutaneous adnexal neoplasms, particularly syringoma, cutaneous metastatic breast cancer, morpheaform basal cell carcinoma and microcystic adnexal carcinoma. The present study reports three cases of DTE. The first case was of a 45-year-old male with an asymptomatic flesh-colored plaque below the right edge of the outer canthus that had been present for seven years. The second case was of a 23-year-old female with an asymptomatic skin lesion on the right cheek that had slowly and progressively increased in size. The third case was of a 26-year-old female who presented with a hard yellowish-white plaque, which gradually grew and formed a rectangular, 3x4-cm patch, on the tip of the left brow. This plaque was present for three years without evident cause or subjective symptoms. In all three cases, the routine systemic examinations and laboratory findings were normal. Histopathological and immunohistochemical findings from incisional biopsies of the lesions were consistent with a diagnosis of DTE. DTE treatment methods and immunohistochemical markers were analyzed by reviewing clinical pathological aspects in order to avoid a misdiagnosis and to provide the best available treatment approach for DTE.

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Cutaneous metastases from carcinoma breast: The common and the rare

Cited by 37 publications

References 0 publications

Can 18F-Fluoroestradiol positron emission tomography become a new imaging standard in the estrogen receptor-positive breast cancer patient: A prospective comparative study with 18F-Fluorodeoxyglucose positron emission tomography?

Can 18F-Fluoroestradiol positron emission tomography become a new imaging standard in the estrogen receptor-positive breast cancer patient: A prospective comparative study with 18F-Fluorodeoxyglucose positron emission tomography?

Carcinoma erysipeloides mimicking radiation dermatitis – a case report and review of literature

Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature

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