Cutaneous metastases from internal carcinoma

Reingold, Irving M.

doi:10.1002/1097-0142(196602)19:2<162::aid-cncr2820190204>3.0.co;2-a

Cited by 285 publications

(151 citation statements)

References 10 publications

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“…1 Autopsy study based data indicate an approximate range of 0.8-5%. [2][3][4] Metastasis can occur at any age, but the incidence rises with advancing age, especially after the fifth decade of life. Skin metastases are believed to be due to systemic spread and they represent terminal stage of malignant disease with limited survival period.…”

Section: Introductionsupporting

confidence: 58%

Metastatic cutaneous and subcutaneous lesions: Analysis of cases diagnosed on fine needle aspiration cytology

Karki¹,

Pathak²,

Manandhar³

et al. 1970

J Pathol Nep

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Background: Cutaneous and subcutaneous metastasis from an underlying primary, indicates a dismal outcome for patients. It is appropriate to use fine needle aspiration cytology as a minimally invasive method for diagnosis. This study emphasises the role of fine needle aspiration cytology in diagnosing metastatic skin nodules. Materials and methods:This was a retrospective study in which the record of all patients subjected to fine needle aspiration cytology from April 2008 -Nov 2010 in the Department of Pathology, Tribhuvan University Teaching Hospital, were reviewed. Of 5,927 patients, 19 cases diagnosed as metastatic skin lesions were included in the study. Results:Out of 19 patients with metastatic skin nodules, 9 patients had metastasis simultaneously with the primary and 8 cases were previously diagnosed. All metastases were from internal solid organ tumours with male to female ratio of 1.7:1. Lung carcinoma was the most common to metastasis in both sexes which included adenocarcinoma (5 cases) and squamous cell carcinoma (6 cases). Common sites for cutaneous/subcutaneous metastasis were the chest wall (9 cases) followed by abdomen (4 cases) and scalp (3 cases). Conclusion:Fine needle aspiration cytology can diagnose a variety of skin lesions which may be supportive in diagnosing a metastasis in cases with known primaries or it may offer a clue to underlying malignancy in unsuspected cases.

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Section: Introductionsupporting

confidence: 58%

Metastatic cutaneous and subcutaneous lesions: Analysis of cases diagnosed on fine needle aspiration cytology

Karki¹,

Pathak²,

Manandhar³

et al. 1970

J Pathol Nep

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“…The most common sites of skin metastases were on the chest and abdomen. 7 Lookingbill et al reviewed 420 patients with cutaneous metastases from melanoma and carcinoma. In this study, tumour registry data from 7,608 patients was evaluated; 4,020 of these patients had metastatic disease and 420(10.4%) had cutaneous metastases.…”

Section: Discussionmentioning

confidence: 99%

A case report of extensive skin metastases from squamous cell carcinoma of lower esophagus and short review of literature

Mukker¹,

Haridas²,

Kallinkeel³

et al. 2016

Int J Res Med Sci

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“…3,4 The reported incidence of metastases on the scalp accounts for about 20% of metastatic skin cancers and these can also arise from lung and gastric cancers. 5 However, skin metastases from colorectal cancer account for only 5% of metastatic skin cancers, of which scalp metastases are very rare. 6 Metastatic invasion of the skin is classified as the continuing process of primary cancer, lymphatic, and bloodstream invasion.…”

Section: Discussionmentioning

confidence: 99%

Skin Metastasis From Sigmoid Colon Cancer

Horiuchi

Nozawa

Akahane

et al. 2011

International Surgery

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Skin metastases from visceral cancers are rare and the reported incidence from all visceral cancers is 1.4% to 10%. Skin metastases from colorectal cancers account for only 5% of metastatic skin cancers, among which scalp metastases are very rare. We describe a 53-year-old man with scalp metastasis derived from sigmoid colon cancer that was diagnosed and surgically resected in 2005. Metastatic lung tumors that developed thereafter were surgically resected and then chemotherapy was administered. However, metastatic brain tumors occurred in 2008, and these were treated by c-knife radiosurgery. Around the same time, a raised lesion that appeared on the scalp was diagnosed as skin metastasis and treated with best supportive care. Thereafter, the brain metastases continued to spread, and the patient died in October 2008.Key words: Skin metastasis -Colon cancer -Scalp metastasis -Brain tumor S kin metastases arising from gastrointestinal cancer are rare, and the theoretical incidence of skin metastases in colorectal cancers is less than 5%.1,2 This case report describes scalp metastasis that developed after surgery for sigmoid colon cancer. Case ReportColonoscopy for a detailed examination of melena revealed sigmoid colon cancer in a 53-year-old man in December 2005 (Fig. 1). Preoperative blood tests revealed carcinoembryonic antigen and cancer antigen 19-9 levels of 6.7 ng/ml and 27.1 U/ml, respectively. Sigmoidectomy was performed in January 2006, and the pathologic diagnosis was well-differentiated adenocarcinoma, lymphovascular invasion (+), T3, N0, M0, stage II. Chest computed tomography (CT) and positron emission tomography imaging in September 2006 revealed an isolated lesion, 6 mm in diameter in the right lung. A metastatic lung tumor was diagnosed (Fig. 2), and in December of the same year the patient underwent thoracoscopic partial resection of the target area in the right lung. The pathologic diagnosis was metastasis from colorectal cancer. The patient received systemic chemotherapy after surgery. However, chest CT images detected tumors in the (Fig. 2), but images obtained in November of the same year revealed recurrence of this tumor and destruction of the right fifth rib. The tumor beds were irradiated with 20 Gy of X-rays to relieve pain and systemic chemotherapy was administered. In April 2008, brain metastases in the left and right frontal lobes were treated by c-knife radiosurgery with target doses of 22 Gy each (Fig. 3). A red, sessile, elastic, firm, raised lesion, 19 mm in diameter, with a glossy surface on the skin of the median area of the occipital region (Fig. 4) was confirmed as skin metastasis of the scalp. This was treated symptomatically. Thereafter, the brain metastases continued to spread, and the patient died in October 2008. DiscussionMetastatic skin cancer is defined as skin metastases from visceral cancer, excluding primary skin cancer and hematologic malignancies. Skin metastases derived from visceral cancers are rare and the reported incidence ranges from 1.4% to 10% of all viscer...

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Cutaneous metastases from internal carcinoma

Cited by 285 publications

References 10 publications

Metastatic cutaneous and subcutaneous lesions: Analysis of cases diagnosed on fine needle aspiration cytology

Metastatic cutaneous and subcutaneous lesions: Analysis of cases diagnosed on fine needle aspiration cytology

A case report of extensive skin metastases from squamous cell carcinoma of lower esophagus and short review of literature

Skin Metastasis From Sigmoid Colon Cancer

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