Cutaneous metastases from internal malignancies

Nashan, Dorothée; Meiß, Frank; Braun‐Falco, Markus; Reichenberger, Sebastian

doi:10.1111/j.1529-8019.2010.01364.x

Cited by 64 publications

(64 citation statements)

References 143 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The diagnosis of a skin metastatic malignancy relies on its histopathology, and often represents a challenge, most particularly when no clinical history or complaint is present. Immunohistochemistry is required for a proper diagnosis (7). In this case report we find the presence of skin metastases, their coexistence with a bone spread < 9 %, and their presentation as the primary tumor's initial manifestation of special interest.…”

Section: Discussionmentioning

confidence: 85%

Skin metastases as initial manifestation of esophageal squamous-cell carcinoma

Rivas-Rivas

Jiménez‐Gallo

Navas-García

et al. 2013

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Esophageal cancer is the sixth most common cause of cancer-related deaths worldwide. Patients with esophageal cancer usually present with locally advanced disease with presence of metastases at diagnosis (1). Squamous-cell carcinoma is the most common histologic subtype in the proximal and middle thirds of the esophagus. Skin metastases from visceral tumors are rare, with a prevalence of up to 2 % (2). An association between esophageal cancer and skin metastases, as in the present case, has only been exceptionally described (3). CASE REPORTA 71-year-old male had a physical exam which revealed an ulcerated, hard tumor outgrowth, approximately 3 cm in size, on his right flank (Fig. 1A), in association with a similar 2.5 cm lesion in the left subclavicular area (Fig. 1B). He had dysphagia to both solids and liquids a few weeks after the development of said lesions, as well as 20 kg weight loss. The endoscopic study revealed a protruding, ulcerated neoplasm at 22 cm from the dental arch, which almost completely occludes the esophageal lumen (Fig. 1C) -histology found it to be an infiltrating squamous-cell carcinoma. A pathological examination of skin lesions revealed cutaneous metastatic infiltration by a squamous-cell carcinoma, with positive immunohistochemical staining for high molecular weight cytokeratine and vimentin (Fig. 2). Additional lab tests found the presence of metastatic bone disease involving the left ribs, D9 vertebral body, and right iliac bone. Treatment with a prosthesis and chemotherapy was ultimately selected. DISCUSSIONSkin manifestations from esophageal cancer are rare, less than 1 %, and were primarily described for adenocarcinoma (1). The presence of skin metastases from an esophageal squamouscell carcinoma is extremely rare, and its review in the literature is limited by its uncommon nature. A study by Lookingbill et al., in 7,316 patients with skin cancer and metastases, found no individuals with a primary esophageal PICTURES IN DIGESTIVE PATHOLOGY

show abstract

Section: Discussionmentioning

confidence: 85%

Skin metastases as initial manifestation of esophageal squamous-cell carcinoma

Rivas-Rivas

Jiménez‐Gallo

Navas-García

et al. 2013

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

show abstract

“…However, very rare cases with extended survival have been reported (5). Local excision, radiotherapy, chemotherapy, immunological and combination therapy have been reported in previous studies (9). Due to the poor outcomes in these patients, the treatment options are limited and primarily supportive in nature.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis from squamous cell carcinoma of the bladder: a case

Beşiroğlu¹,

Erkoç²,

Şahin³

et al. 2017

Bagcilar Medical Bulletin

View full text Add to dashboard Cite

Objective: To report a case with cutaneous metastasis of bladder squamous cell carcinoma. Very few cases of skin metastases from the urinary bladder are reported in the literature.Case report: Cutaneous metastasis of bladder squamous cell carcinoma is an extremely rare clinic entity associated with poor prognosis. Cutaneous metastasis is accepted as a late manifestation of systemic spread. A 58-year-old man had undergone radical cystoprostatectomy with pelvic lymph node dissection in November 2013. The pathology report showed a moderately differentiated squamous cell bladder carcinoma with a staging of T3N0M0. Then, a large regional cutaneous lesion measuring 4x3.5 cm with an ulcerated and necrotic appearance located in the suprapubic area was detected in February 2014, and the lesion was removed with a 2 cm safety margin. The pathologic examination revealed squamous cell carcinoma. This report describes an interesting and rare case of cutaneous metastasis of bladder squamous cell carcinoma as the primary presentation of metastatic disease with a generally dismal prognosis. Conclusion:The skin metastasis of bladder squamous cell carcinoma is a rare clinical entity with a poor prognosis. Clinicians should be aware of this rare entity.

show abstract

“…[9] The prognosis of patients with cutaneous spread of bladder cancer is generally poor and the median survival is less than 12 months. [10] …”

Section: Discussionmentioning

confidence: 99%