Cutaneous Metastases from Lung Adenocarcinoma

Abstract

Cutaneous metastases are unusual presenting symptoms of lung cancer. Therefore, they are prone to be misdiagnosed and missed. The report describes a case of a forty-nine-year-old female with painful zosteriform rashes showing multiple vesicle-like papules localized on the left breast for 10 days. The patient had been diagnosed as lung adenocarcinoma at the department of oncology one year ago. Skin biopsy revealed blue nodular lesions in the dermis, composed of clustered heterogeneous tumor cells with glandular formation. Immunohistochemical stains confirmed the diagnosis of metastatic lung adenocarcinoma.

Rare cutaneous manifestation of zosteriform cutaneous metastases of lung cancer: Two cases and literature review

“…Zosteriform cutaneous metastases are a rare presentation, with limited number of reported cases documented in the literature. [1][2][3][4][5] We reviewed previously reported cases of zosteriform cutaneous metastases originating from lung cancer (Table S1). [1][2][3][4][5] Among the 13 cases analyzed, the majority had cutaneous metastases on the ipsilateral face and trunk, with the exception of case 6.…”

“…[1][2][3][4][5] We reviewed previously reported cases of zosteriform cutaneous metastases originating from lung cancer (Table S1). [1][2][3][4][5] Among the 13 cases analyzed, the majority had cutaneous metastases on the ipsilateral face and trunk, with the exception of case 6. This observation suggests the mechanism of lymphovascular invasion by tumor cells.…”

Skin Metastases As First Manifestations of Adenocarcinoma of the Lung: A Case Report

“…However, in cases of multiple skin metastases, chemotherapy is the primary treatment. The response of skin lesions serves as a marker of treatment response, despite the usually low survival in these cases [ 10 ]. Radiotherapy can also be used alone or in combination with chemotherapy in these cases.…”

“…Patient prognosis with lung cancer and skin metastases is poor and survival is usually a few months only, ranging from 3 to 15 months, depending on the clinical presentation of each patient, as well as the therapeutic approach used. In some cases, palliative strategies help to prolong survival [ 2 , 4 , 5 , 7 , 10 , 11 ]. At about 6 months of follow-up care in the oncology unit, the patient analyzed in this study died.…”

Erythematous Tumour Above the Right Clavicula: A Quiz

“…Skin metastases usually develop in patients with advanced disease and, very rarely, they constitute the presenting lesion of the malignancy ( 4 ). Cutaneous metastases have an inconsistent clinical appearance, ranging from erythematous papules to nodules or, more rarely, plaques and, not infrequently, they can imitate benign skin diseases ( 5 ). Histopathologically, cutaneous metastases show a dense infiltrate of tumour cells in the dermis, occasionally with extension into the subcutaneous tissue ( 6 ).…”