Cutaneous metastases of cervical adenosquamous carcinoma

A case of cutaneous metastatic adenosquamous carcinoma of the cervix

“…Ulcerations are uncommon; however, our patient presented with ulcerated plaques in addition to multiple nodules. 1, [4][5][6] Histopathologically, adenosquamous carcinoma metastases demonstrate a biphasic pattern of well-defined malignant DISCUSSION glandular and squamous features. Special stains may aid in diagnosis, including p63 for the squamous component and CK7+/CK20for both cervical squamous cell carcinoma and adenocarcinoma components.…”

“…In 1966, Reingold added an addendum to his review of metastases from internal carcinoma to include a 43-year-old female who had metastases of adenosquamous carcinoma to the thighs and lower abdomen .3 In 2010, Fumerton et al presented the first case report of adenosquamous carcinoma metastasizing to the lower abdomen, hips, and groin in a 32year-old women who passed away within 3 months of the cutaneous lesions appearing. 4 Irrespective of histologic subtype, cutaneous metastases of cervical carcinoma predict a poor prognosis, as this usually occurs with local or regional recurrence. 4,5,9,10 The incidence of skin metastasis increases with an increasing initial tumor stage, with an incidence of 0.8% in stage I and 4.8% in stage IV.…”

“…4 Irrespective of histologic subtype, cutaneous metastases of cervical carcinoma predict a poor prognosis, as this usually occurs with local or regional recurrence. 4,5,9,10 The incidence of skin metastasis increases with an increasing initial tumor stage, with an incidence of 0.8% in stage I and 4.8% in stage IV. 5 Cutaneous metastases typically present a year after the diagnosis of cervical cancer, although they may develop up to 10 years after the initial diagnosis.…”