Cutaneous metastases of lung cancer

Garrido, María José Molina; Ponce, Carmen Guillén; Soto, José Luís; Sevila, C. Martínez y; Mena, Alfredo Carrato; Antón, Fernando Moreno

doi:10.1007/s12094-006-0178-6

Cited by 49 publications

(46 citation statements)

References 14 publications

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“…Among the 12 cases we evaluated, histopathological examinations showed 7 cases of poorly differentiated SCC, 1 adenosquamous cell carcinoma, 1 oat cell carcinoma, 1 anaplastic large cell carcinoma, and 1 large cell undifferentiated carcinoma. Coslett & Katlic (19) and Molina Garrido et al (20) found that among primary lung tumours, those in the upper lobes of the lung tended to metastasize more frequently to the skin.…”

Section: Discussionmentioning

confidence: 99%

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature

Chun¹,

Kim²,

Lee³

et al. 2013

Acta Derm Venerol

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Cutaneous metastatic carcinoma of the nose is a rare presentation associated with lung cancer. We report here 3 cases of cutaneous metastatic carcinoma of the nose that originated from lung cancer. Two men, age 61 and 76 years, with lung cancers were referred for evaluation of a tumour on the tip of the nose. The third patient, a 57-year-old man, had developed a rosacea-like tumour on the tip of the nose; although he had no history of internal cancer, whole-body positron-emission tomography-computed tomography revealed a primary lung cancer. Skin biopsies of all 3 cases showed metastatic squamous cell carcinoma, and all primary lung cancers were squamous cell carcinomas. Only 3 patients are described here, and further reports are needed to substantiate this interesting phenomenon. When an elderly patient presents to dermatology with a tumour on the nose with or without known internal cancer, it is necessary to approach the diagnosis with caution.

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Section: Discussionmentioning

confidence: 99%

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature

Chun¹,

Kim²,

Lee³

et al. 2013

Acta Derm Venerol

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“…As a manifestation of breast and oral cavity cancers, skin lesions can present as nodules of sclerotic and inflammatory appearance; they can also present as a direct extension of the primary tumor. (13) Some lesions are intradermal and invade subcutaneous cellular tissue, whereas others are superficial, with no specific color or location that would indicate their nature. (11,13) They generally present as late manifestations of disseminated neoplastic disease.…”

Section: Discussionmentioning

confidence: 99%

“…(13) Some lesions are intradermal and invade subcutaneous cellular tissue, whereas others are superficial, with no specific color or location that would indicate their nature. (11,13) They generally present as late manifestations of disseminated neoplastic disease. However, they can be the first clinical manifestation of thoracic or abdominal tumors.…”

Section: Discussionmentioning

confidence: 99%

Metástase cutânea como primeira manifestação de adenocarcinoma pulmonar

et al. 2011

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associated with a worse prognosis. (6,7) Physicians who deal with this pathology should be on the alert for the possibility of cutaneous metastasis as the initial manifestation of lung cancer. Case reportA 58-year-old waiter who had quit smoking 9 years prior (smoking history, 40 pack-years) was referred for medical oncology consultation because of an epigastric mass. The patient presented with a history of COPD with severe IntroductionAnnually, metastatic disease accounts for over half of the new cases of lung cancer in Europe.(1) In Portugal, the estimated annual incidence is approximately 2,500 cases, and mortality among such cases is nearly 100%, lung cancer being the leading cause of cancer death.(1,2) To date, there has been no evidence of an effective method for population screening, (3) smoking cessation being fundamental to reducing the number of cases. AbstractWe report the case of a 58-year-old male patient who was referred for oncology consultation due to an epigastric mass that had been growing rapidly for three months. Diagnostic investigation revealed that the mass was a metastasis of stage IV lung adenocarcinoma. The patient received five cycles of chemotherapy with cisplatin and gemcitabine as a first-line treatment, which was interrupted due to major adverse events. Although the pulmonary disease stabilized, the cutaneous disease progressed. The patient then received pemetrexed as a secondline chemotherapy, together with concurrent external radiotherapy, which was well tolerated. There was complete remission of the epigastric mass. However, the patient died three months after the treatment. Here, we emphasize the importance of a multidisciplinary approach and of its role in individualizing the treatment.

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“…Why tumors in the upper lobes of lungs have a greater probability to metastasize to the skin than tumors of the middle and lower lobes is unclear [7]. No other features of the primary tumor have been associated with an increased probability of metastasizing to the skin.…”

Section: Sirmentioning

confidence: 99%